Just Keep Swimming: Neuroendocrine, Metabolic, and Behavioral Changes After a Forced Swimming Test in Zebrafish

Just Keep Swimming: Neuroendocrine, Metabolic, and Behavioral Changes After a Forced Swimming Test in Zebrafish

In this study, we show that an adaptation of the spinning test can be used as a model to study the exercise-exhaustion-recovery paradigm in fish. This forced swimming test promotes a wide range of changes in the hypothalamus-pituitary-interrenal axis functioning, intermediary metabolism, as well in...

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Bibliographic Details
Published in:Zebrafish Vol. 14; no. 1; p. 51
Main Authors: da Rosa, João Gabriel Santos, Barcellos, Heloísa Helena de Alcântara, Idalencio, Renan, Marqueze, Alessandra, Fagundes, Michele, Rossini, Mainara, Variani, Cristiane, Balbinoti, Francine, Tietböhl, Tássia Michele Huff, Rosemberg, Denis Broock, Barcellos, Leonardo José Gil
Format: Journal Article
Language:English
Published: United States 01-02-2017
Subjects:
Animals
Behavior, Animal
Creatine Kinase - analysis
Energy Metabolism
Glucose - analysis
Hydrocortisone - analysis
Models, Animal
Physical Conditioning, Animal - methods
Stress, Physiological
Swimming
Zebrafish - blood
Zebrafish - physiology
cortisol
anxiety-like behavior
novel tank test
exercise levels
exercise-exhaustion-recovery paradigm
Danio rerio
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Summary:In this study, we show that an adaptation of the spinning test can be used as a model to study the exercise-exhaustion-recovery paradigm in fish. This forced swimming test promotes a wide range of changes in the hypothalamus-pituitary-interrenal axis functioning, intermediary metabolism, as well in fish behavior at both exercise and recovery periods. Our results pointed that this adapted spinning test can be considered a valuable tool for evaluating drugs and contaminant effects on exercised fish. This can be a suitable protocol both to environmental-to evaluate contaminants that act in fish energy mobilization and recovery after stressors-and translational perspectives-effects of drugs on exercised or stressed humans.
ISSN:1557-8542
DOI:10.1089/zeb.2016.1340