Search Results - "Tierney, Ciara"

Next generation proteomics with drug sensitivity screening identifies sub-clones informing therapeutic and drug development strategies for multiple myeloma patients by Tierney, Ciara, Bazou, Despina, Majumder, Muntasir M., Anttila, Pekka, Silvennoinen, Raija, Heckman, Caroline A., Dowling, Paul, O’Gorman, Peter

“…With the introduction of novel therapeutic agents, survival in Multiple Myeloma (MM) has increased in recent years. However, drug-resistant clones inevitably…”
Get full text

Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry by Rossi, Rosanna, Molina, Sara, Mereuta, Oana Madalina, Douglas, Andrew, Fitzgerald, Seán, Tierney, Ciara, Pandit, Abhay, Brennan, Paul, Power, Sarah, O’Hare, Alan, Gilvarry, Michael, McCarthy, Ray, Magoufis, Georgios, Tsivgoulis, Georgios, Nagy, András, Vadász, Ágnes, Jood, Katarina, Redfors, Petra, Nordanstig, Annika, Ceder, Erik, Dunker, Dennis, Carlqvist, Jeanette, Psychogios, Klearchos, Szikora, István, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, Doyle, Karen M.

“…Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be…”
Get full text

Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources by Silva, Lilian Pereira, Frawley, Dean, Assis, Leandro José de, Tierney, Ciara, Fleming, Alastair B., Bayram, Ozgur, Goldman, Gustavo Henrique

“…Aspergillus fumigatus is an important human-pathogenic fungal species that is responsible for a high incidence of infections in immunocompromised individuals…”
Get full text

Potential Biomarkers of Acute Ischemic Stroke Etiology Revealed by Mass Spectrometry-Based Proteomic Characterization of Formalin-Fixed Paraffin-Embedded Blood Clots by Rossi, Rosanna, Mereuta, Oana Madalina, Barbachan E Silva, Mariel, Molina Gil, Sara, Douglas, Andrew, Pandit, Abhay, Gilvarry, Michael, McCarthy, Ray, O'Connell, Shane, Tierney, Ciara, Psychogios, Klearchos, Tsivgoulis, Georgios, Szikora, István, Tatlisumak, Turgut, Rentzos, Alexandros, Thornton, John, Ó Broin, Pilib, Doyle, Karen M

“…Besides the crucial role in the treatment of acute ischemic stroke (AIS), mechanical thrombectomy represents a unique opportunity for researchers to study the…”
Get full text

CAR Gene Delivery by T‐cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms by Charitidis, Filippos T, Adabi, Elham, Ho, Naphang, Braun, Angela H, Tierney, Ciara, Strasser, Lisa, Thalheimer, Frederic B, Childs, Liam, Bones, Jonathan, Clarke, Colin, Buchholz, Christian J

“…Lentiviral vectors (LV) have become the dominant tool for stable gene transfer into lymphocytes including chimeric antigen receptor (CAR) gene delivery to T…”
Get full text

Identification of Protein Biomarker Signatures for Acute Myeloid Leukemia (AML) Using Both Nontargeted and Targeted Approaches by Dowling, Paul, Tierney, Ciara, Dunphy, Katie, Miettinen, Juho J., Heckman, Caroline A., Bazou, Despina, O’Gorman, Peter

“…Acute myeloid leukemia (AML) is characterized by an increasing number of clonal myeloid blast cells which are incapable of differentiating into mature…”
Get full text

S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma by Liu, Minxia, Wang, Yinyin, Miettinen, Juho J., Kumari, Romika, Majumder, Muntasir Mamun, Tierney, Ciara, Bazou, Despina, Parsons, Alun, Suvela, Minna, Lievonen, Juha, Silvennoinen, Raija, Anttila, Pekka, Dowling, Paul, O’Gorman, Peter, Tang, Jing, Heckman, Caroline A.

“…Despite several new therapeutic options, multiple myeloma (MM) patients experience multiple relapses and inevitably become refractory to treatment. Insights…”
Get full text

Saliva-Omics in Plasma Cell Disorders — Proof of Concept and Potential As a Non-Invasive Tool for Monitoring Disease Burden and MRD Status by Tierney, Ciara, Bazou, Despina, Le, Giao, Dowling, Paul, O'Gorman, Peter

“…Salivaomics has exciting potential for the diagnosis and monitoring of malignancy, evidence of which has been reported in oral cancer (Sahibzada et al., 2017),…”
Get full text

Saliva-omics in plasma cell disorders- Proof of concept and potential as a non-invasive tool for monitoring disease burden by Tierney, Ciara, Bazou, Despina, Lê, Giao, Dowling, Paul, O'Gorman, Peter

“…Multiple Myeloma (MM), the second most common lymphoid cancer worldwide, is characterised by the uninhibited proliferation of terminally differentiated…”
Get full text

Proteomic Characterisation of Patient Samples Diagnosed with Haematological Malignancies by Tierney, Ciara

“…Multiple myeloma (MM) is the second most commonly diagnosed lymphoid cancer worldwide, after non-Hodgkin’s lymphoma, and is characterised by the uninhibited…”
Get full text

Saliva-omics in Plasma Cell Disorders-proof of concept and potential as a non-invasive tool for monitoring disease burden and MRD status by Tierney, Ciara, Bazou, Despina, Le, Giao, Dowling, Paul, O'Gorman, Peter

Get full text

Combining Next Generation Proteomics Platforms with Drug Sensitivity Resistance Testing Allows Identification of Physiologically Distinct Sub-Clones That Can Inform Therapeutic and Drug Development Strategies by Bazou, Despina, Majumder, Muntasir M, Tierney, Ciara, O'Rourke, Sinead, Anttila, Pekka, Silvennoinen, Raija Helena, Heckman, Caroline A, Dowling, Paul, O'Gorman, Peter

“…Introduction: A hallmark of Multiple Myeloma (MM) is the sequel development of drug resistant phenotypes, which may be present initially or emerge during the…”
Get full text

Phase 2 studies of lenalidomide, subcutaneous bortezomib, and dexamethasone as induction therapy in patients with newly diagnosed multiple myeloma by O'Gorman, Peter, Laubach, Jacob P., O'Dwyer, Michael E., Krawczyk, Janusz, Yee, Andrew J., Gilligan, Oonagh, Cahill, Mary R., Rosenblatt, Jacalyn, Quinn, John, Murphy, Philip T., DiPietro, Heidi, Perera, Meegahage Ratnakanthi, Crotty, Gerard M., Cummings, Kristen, Hayden, Patrick J., Browne, Paul, Savell, Alexandra, O'Leary, Hilary M., O'Keeffe, Denis, Masone, Kelly, Hennessy, Brian J., Guerrero Garcia, Thomas, Scott, Kathleen, Saeed, Khalid, Bianchi, Giada, Dowling, Paul, Tierney, Ciara, Richardson, Paul G.

“…There are limited prospective data on lenalidomide, subcutaneous bortezomib, and dexamethasone (RsqVd) in transplant‐eligible/transplant‐ineligible patients…”
Get full text

Next Generation Proteomics and Drug Sensitivity Resistance Testing Allow for the Identification of Distinct Sub-clones of Multiple Myeloma Patients by Bazou, Despina, Majumder, Muntasir Mamun, Tierney, Ciara, Anttila, Pekka, Silvennoinen, Raija, Heckman, Caroline, Dowling, Paul, O'Gorman, Peter

Get full text