Search Results - "Tierney, Brent J"

HO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer by RATH, Kellie S, NAIDU, Shan K, HOUGHTON, Peter, HIDEG, Kálmán, KUPPUSAMY, Periannan, COHN, David E, SELVENDIRAN, Karuppaiyah, LATA, Pushpa, BID, Hemant K, RIVERA, Brian K, MCCANN, Georgia A, TIERNEY, Brent J, ELNAGGAR, Adam C, BRAVO, Veronica, LEONE, Gustavo

“…STAT3 is well corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors…”
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HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells by Tierney, Brent J., McCann, Georgia A., Cohn, David E., Eisenhauer, Eric, Sudhakar, Meryl, Kuppusamy, Periannan, Hideg, Kálmán, Selvendiran, Karuppaiyah

“…BRCA1 plays an important role in DNA damage and repair, homologous recombination, cell-cycle regulation and apoptosis. BRCA-mutated ovarian cancer often…”
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Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor by Tierney, Brent J, McCann, Georgia A, Naidu, Shan, Rath, Kellie S, Saini, Uksha, Wanner, Ross, Kuppusamy, Periannan, Suarez, Adrian, Goodfellow, Paul J, Cohn, David E, Selvendiran, Karuppaiyah

“…Abstract Objective Constitutive activation of STAT3 is a hallmark of various human cancers, however an increased pSTAT3 expression in high grade human…”
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Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor by McCann, Georgia A, Naidu, Shan, Rath, Kellie S, Bid, Hemant K, Tierney, Brent J, Suarez, Adrian, Varadharaj, Saradhadevi, Zhang, Jianying, Hideg, Kálmán, Houghton, Peter, Kuppusamy, Periannan, Cohn, David E, Selvendiran, Karuppaiyah

“…Tumor hypoxia, a feature of many solid tumors including ovarian cancer, is associated with resistance to therapies. We previously demonstrated that hypoxic…”
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Infantile Myofibromatosis: A Nontraumatic Cause of Neonatal Brachial Plexus Palsy by Tierney, Travis S., MD, DPhil, Tierney, Brent J., MD, Rosenberg, Andrew E., MD, Krishnamoorthy, Kalpathy S., MD, Butler, William E., MD

“…Most injuries to the neonatal brachial plexus occur acutely at birth, and are iatrogenic in origin. However, when weakness is accompanied by atrophy,…”
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Homocysteine inhibits cardiac neural crest cell formation and morphogenesis in vivo by Tierney, Brent J., Ho, Trang, Reedy, Mark V., Brauer, Philip R.

“…Elevated homocysteine increases the risk of neurocristopathies. Here, we determined whether elevating homocysteine altered the proliferation or number of chick…”
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Complications after double-barreled wet colostomy compared to separate urinary and fecal diversion during pelvic exenteration: Time to change back? by Backes, Floor J, Tierney, Brent J, Eisenhauer, Eric L, Bahnson, Robert R, Cohn, David E, Fowler, Jeffrey M

“…Abstract Objective To assess complications associated with double-barreled wet colostomy (DBWC) in the first six months after pelvic exenteration as compared…”
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Does intra-operative radiation at the time of pelvic exenteration improve survival for patients with recurrent, previously irradiated cervical, vaginal, or vulvar cancer? by Backes, Floor J, Billingsley, Caroline C, Martin, Douglas D, Tierney, Brent J, Eisenhauer, Eric L, Cohn, David E, O'Malley, David M, Salani, Ritu, Copeland, Larry J, Fowler, Jeffrey M

“…Abstract Objective To determine whether intra-operative radiation therapy (IORT) at the time of pelvic exenteration (PE) or laterally extended endopelvic…”
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Abstract POSTER-THER-1413: Targeting constitutively-activated STAT3 in hypoxic ovarian cancer by McCann, Georgia A, ElNaggar, Adam, Naidu, Shan, Rath, Kellie S, Tierney, Brent J, Suarez, Adrian, Cohn, David E, Selvendiran, Karuppaiyah

“…Abstract Background: Tumor hypoxia, a feature of many solid tumors including ovarian cancer, is associated with resistance to therapies. We previously…”
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Abstract 2032: Inhibition of signal transducers and activators of transcription 3 in human endometrial cancer, using a novel STAT3 inhibitor by Tierney, Brent J., McCann, Georgia A., Rath, Kellie S., Sudhakar, Meryl, Naidu, Shan, Kuppusamy, Periannan, Cohn, David E., Selvendiran, Karuppaiyah

“…Abstract OBJECTIVE: Signal transducer and activator of transcription 3 (Stat3) proteins have important roles in cancer cell survival and proliferation. Recent…”
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Abstract 2802: Selective inhibition of signal transducers and activators of transcription 3 overexpressing endometrial cancer cells, using HO-3867, a novel STAT3 inhibitor by McCann, Georgia, Tierney, Brent J., Cohn, David, Sudhakar, Meryl, Naidu, Shan, Eisenhauer, Eric, Karuppaiyah, Selvendiran

“…Abstract OBJECTIVE: Signal transducer and activator of transcription 3 (STAT3) proteins have important roles in cancer cell survival and proliferation. Recent…”
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Abstract 4723: HO-3867, a STAT3 inhibitor induces G2/M arrest and apoptosis in BRCA1-mutated ovarian cancer cells by Tierney, Brent J., McCann, Georgia, Cohn, David E., Sudhakar, Meryl, O'Malley, David, Karuppaiyah, Selvendiran

“…Abstract Background: BRCA1 plays an important role in DNA damage and repair, homologous recombination, cell-cycle regulation, and apoptosis. BRCA-mutated…”
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Abstract 3940: Activation of Signal Transducer and Activator of Transcription 3 (STAT3) in ovarian cancer: The hypoxic implications by McCann, Georgia A., Naidu, Shan, Tierney, Brent J., Sudhakar, Meryl, Cohn, David E., Selvendiran, Karuppaiyah

“…Abstract Background: The hypoxic microenvironment plays a key role in tumorigenesis and the development of therapeutic resistance in epithelial ovarian cancer…”
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Myofibromatosis : A Nontraumatic Cause of Neonatal Brachial Plexus Palsy by TIERNEY, Travis S, TIERNEY, Brent J, ROSENBERG, Andrew E, KRISHNAMOORTHY, Kalpathy S, BUTLER, William E

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