Search Results - "Tienari, P"

Frequency and risk factors of rebound after fingolimod discontinuation – A retrospective study by Maunula, A, Atula, S, Laakso, SM, Tienari, PJ

“…•After fingolimod (FTY) discontinuation 10.5% of patients experienced rebound and in total 28% experienced a relapse.•Longer time on FTY treatment, younger age…”
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Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease by LUOMA, P. T, EEROLA, J, AHOLA, S, HAKONEN, A. H, HELLSTROM, O, KIVISTO, K. T, TIENARI, P. J, SUOMALAINEN, A

“…Dysfunction of mitochondrial DNA polymerase gamma (POLG) has been recently recognized as an important cause of inherited neurodegenerative diseases. We have…”
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Primary familial brain calcification linked to deletion of 5’ noncoding region of SLC20A2 by Pasanen, P., Mäkinen, J., Myllykangas, L., Guerreiro, R., Bras, J., Valori, M., Viitanen, M., Baumann, M., Tienari, P. J., Pöyhönen, M., Baumann, P.

“…Objectives Primary familial brain calcification (PFBC) is a rare neurological disease often inherited as a dominant trait. Mutations in four genes (SLC20A2,…”
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DARS2 mutations in mitochondrial leucoencephalopathy and multiple sclerosis by Isohanni, P, Linnankivi, T, Buzkova, J, Lönnqvist, T, Pihko, H, Valanne, L, Tienari, P J, Elovaara, I, Pirttilä, T, Reunanen, M, Koivisto, K, Marjavaara, S, Suomalainen, A

“…Leucoencephalopathy with brain stem and spinal cord involvement and high brain lactate (LBSL) was first defined by characteristic magnetic resonance imaging…”
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How useful is [123I]β-CIT SPECT in clinical practice? by Eerola, J, Tienari, P J, Kaakkola, S, Nikkinen, P, Launes, J

“…Objective: To assess the accuracy and clinical usefulness of [123I]β-CIT (2β-carbomethoxy-3β-(4-iodophenyl)tropane) SPECT in the differential diagnosis of…”
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Intrafamilial clinical variability in individuals carrying the CHCHD10 mutation Gly66Val by Pasanen, P., Myllykangas, L., Pöyhönen, M., Kiuru-Enari, S., Tienari, P. J., Laaksovirta, H., Toppila, J., Ylikallio, E., Tyynismaa, H., Auranen, M.

“…Objectives Mutations in the CHCHD10 gene, which encodes a mitochondrially targeted protein, have emerged as an important cause of motor neuron disease and…”
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Response to ‘Re. Doppler Ultrasound Examination of Multiple Sclerosis Patients and Control Participants: Inter-observer Agreement and Association with Disease’ by Laukontaus, S, Tienari, P, Lepäntalo, M, Venermo, M

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Association of parental Communication Deviance with offspring's psychiatric and thought disorders. A systematic review and meta-analysis by Roisko, R, Wahlberg, K.-E, Miettunen, J, Tienari, P

“…Abstract Elevated number of parental Communication Deviance (CD) has been connected with psychiatric and thought disorders in their offspring. However, no…”
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Multiple sclerosis in Finland: incidence trends and differences in relapsing remitting and primary progressive disease courses by Sumelahti, M-L, Tienari, P J, Hakama, M, Wikström, J

“…Objective: To compare the secular trends and geographical differences in the incidence of relapsing-remitting (RRMS) and primary progressive multiple sclerosis…”
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Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotype by Tanskanen, M., Lindsberg, P. J., Tienari, P. J., Polvikoski, T., Sulkava, R., Verkkoniemi, A., Rastas, S., Paetau, A., Kiuru-Enari, S.

“…There is growing evidence that in Alzheimer's disease (AD) amyloid β‐protein (Aβ) triggers a chronic inflammatory reaction in cerebral amyloid plaques,…”
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Doppler Ultrasound Examination of Multiple Sclerosis Patients and Control Participants: Inter-observer Agreement and Association with Disease by Laukontaus, S.J, Kagayama, T, Lepäntalo, M, Atula, S, Färkkilä, M, Albäck, A, Inoue, Y, Tienari, P, Venermo, M

“…Objective Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a major risk factor for multiple sclerosis (MS). The aim of this study was to…”
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A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2 by Tienari, Pentti J, Holmdahl, Rikard, Peltonen, Leena, Terwilliger, Joseph D, Pettersson, Ulf, Kuokkanen, Satu, Sundvall, Mats, Wikström, Juhani

“…Multiple sclerosis (MS) is a chronic inflammatory disorder characterized by multifocal damage of myelin in the central nervous system (CNS). The prevalence of…”
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Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families by Kuokkanen, Satu, Gschwend, Michele, Rioux, John D., Daly, Mark J., Terwilliger, Joseph D., Tienari, Pentti J., Wikström, Juhani, Palo, Jorma, Stein, Lincoln D., Hudson, Thomas J., Lander, Eric S., Peltonen, Leena

“…Multiple sclerosis (MS) is a neurological, demyelinating disorder with a putative autoimmune etiology. It is thought to be a multifactorial disease with a…”
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Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis by Öckinger, J, Stridh, P, Beyeen, A D, Lundmark, F, Seddighzadeh, M, Oturai, A, Sørensen, P S, Lorentzen, Å R, Celius, E G, Leppä, V, Koivisto, K, Tienari, P J, Alfredsson, L, Padyukov, L, Hillert, J, Kockum, I, Jagodic, M, Olsson, T

“…Multiple sclerosis (MS) is a complex disorder of the central nervous system, causing inflammation, demyelination and axonal damage. A limited number of genetic…”
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Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD by EEROLA, J, HERNANDEZ, D, SINGLETON, A. B, LAUNES, J, HELLSTRÖM, O, HAGUE, S, GULICK, C, JOHNSON, J, PEURALINNA, T, HARDY, J, TIENARI, P. J

“…Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing…”
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Apolipoprotein E ( APOE), PARKIN and catechol- O-methyltransferase ( COMT) genes and susceptibility to sporadic Parkinson's disease in Finland by Eerola, J, Launes, J, Hellström, O, Tienari, P.J

“…Recent studies have demonstrated that genetic factors modify susceptibility to sporadic Parkinson's disease (PD). So far the results of candidate gene studies…”
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Interaction between genetic vulnerability and family environment: the Finnish adoptive family study of schizophrenia by Tienari, P

“…A nationwide Finnish sample of schizophrenics' offspring given up for adoption was compared blindly with matched controls, that is, adopted-away offspring of…”
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Testing association between LRRK2 and Parkinson’s disease and investigating linkage disequilibrium by Paisán-Ruíz, C, Evans, E W, Jain, S, Xiromerisiou, G, Gibbs, J R, Eerola, J, Gourbali, V, Hellström, O, Duckworth, J, Papadimitriou, A, Tienari, P J, Hadjigeorgiou, G M, Singleton, A B

“…Background: We and others recently identified the gene underlying PARK8 linked Parkinson’s disease (PD). This gene, LRRK2, contains mutations that cause an…”
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BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups by Xiromerisiou, G., Hadjigeorgiou, G.M., Eerola, J., Fernandez, H.H., Tsimourtou, V., Mandel, R., Hellström, O., Gwinn-Hardy, K., Okun, M.S., Tienari, P.J., Singleton, A.B.

“…Experimental and clinical data suggest that genetic variations in brain-derived neurotrophic factor (BDNF) gene may affect risk for Parkinson's disease (PD)…”
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Increasing prevalence of multiple sclerosis in Finland by Sumelahti, M-L., Tienari, P. J., Wikström, J., Palo, J., Hakama, M.

“…Objectives – To follow‐up the prevalence trends of MS from 1983 to 1993 in western and southern Finland. MS epidemiology has been previously followed from 1964…”
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