Search Results - "Tiemessen, Caroline T"

FcγR Genetic Variation and HIV-1 Vaccine Efficacy: Context And Considerations by Lassaunière, Ria, Tiemessen, Caroline T

“…Receptors for the crystallisable fragment (Fc) of immunoglobulin (Ig) G, Fcγ receptors (FcγRs), link the humoral and cellular arms of the immune response,…”
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The many faces of HIV elite control by Tiemessen, Caroline T.

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A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation by Violari, Avy, Cotton, Mark F., Kuhn, Louise, Schramm, Diana B., Paximadis, Maria, Loubser, Shayne, Shalekoff, Sharon, Da Costa Dias, Bianca, Otwombe, Kennedy, Liberty, Afaaf, McIntyre, James, Babiker, Abdel, Gibb, Diana, Tiemessen, Caroline T.

“…Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure…”
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FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1 by Ebonwu, Joy, Lassaunière, Ria, Paximadis, Maria, Strehlau, Renate, Gray, Glenda E., Kuhn, Louise, Tiemessen, Caroline T.

“…Background Some mother-to-child transmission (MTCT) studies suggest that allelic variations of Fc gamma receptors (FcγR) play a role in infant HIV-1…”
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T-cell responses to ancestral SARS-CoV-2 and Omicron variant among unvaccinated pregnant and postpartum women living with and without HIV in South Africa by McMahon, William C., Kwatra, Gaurav, Izu, Alane, Jones, Stephanie A., Mbele, Nkululeko J., Jafta, Nwabisa, Lala, Rushil, Shalekoff, Sharon, Tiemessen, Caroline T., Madhi, Shabir A., Nunes, Marta C.

“…SARS-CoV-2 cell-mediated immunity remains understudied during pregnancy in unvaccinated Black African women living with HIV (WLWH) from low- and middle-income…”
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Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy by Morris, Sinead E, Strehlau, Renate, Shiau, Stephanie, Abrams, Elaine J, Tiemessen, Caroline T, Kuhn, Louise, Yates, Andrew J

“…In 2019 there were 490,000 children under five living with HIV. Understanding the dynamics of HIV suppression and rebound in this age group is crucial to…”
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Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children by Kuhn, Louise, Paximadis, Maria, Da Costa Dias, Bianca, Loubser, Shayne, Strehlau, Renate, Patel, Faeezah, Shiau, Stephanie, Coovadia, Ashraf, Abrams, Elaine J, Tiemessen, Caroline T

“…The latent viral reservoir is the major obstacle to achieving HIV remission and necessitates life-long antiretroviral therapy (ART) for HIV-infected…”
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Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages by Nkone, Paballo, Loubser, Shayne, Quinn, Thomas C, Redd, Andrew D, Ismail, Arshad, Tiemessen, Caroline T, Mayaphi, Simnikiwe H

“…Despite multiple attempts, there is still no effective HIV-1 vaccine available. The HIV-1 polymerase (pol) gene is highly conserved and encodes cytotoxic…”
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Human whole genome sequencing in South Africa by Glanzmann, Brigitte, Jooste, Tracey, Ghoor, Samira, Gordon, Richard, Mia, Rizwana, Mao, Jun, Li, Hao, Charls, Patrick, Douman, Craig, Kotze, Maritha J., Peeters, Armand V., Loots, Glaudina, Esser, Monika, Tiemessen, Caroline T., Wilkinson, Robert J., Louw, Johan, Gray, Glenda, Warren, Robin M., Möller, Marlo, Kinnear, Craig

“…The advent and evolution of next generation sequencing has considerably impacted genomic research. Until recently, South African researchers were unable to…”
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Correction to: Deep sequencing of the HIV-1 polymerase gene for characterisation of cytotoxic T-lymphocyte epitopes during early and chronic disease stages by Nkone, Paballo, Loubser, Shayne, Quinn, Thomas C, Redd, Andrew D, Ismail, Arshad, Tiemessen, Caroline T, Mayaphi, Simnikiwe H

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An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition by Ebonwu, Joy, Lassaunière, Ria, Paximadis, Maria, Goosen, Mark, Strehlau, Renate, Gray, Glenda E, Kuhn, Louise, Tiemessen, Caroline T

“…In the Thai RV144 HIV-1 vaccine trial, a three-variant haplotype within the Fc gamma receptor 2C gene ( ) reduced the risk of HIV-1 acquisition. A follow-on…”
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Evaluation of the HIV-1 Polymerase Gene Sequence Diversity for Prediction of Recent HIV-1 Infections Using Shannon Entropy Analysis by Nkone, Paballo, Loubser, Shayne, Quinn, Thomas C, Redd, Andrew D, Laeyendecker, Oliver, Tiemessen, Caroline T, Mayaphi, Simnikiwe H

“…HIV-1 incidence is an important parameter for assessing the impact of HIV-1 interventions. The aim of this study was to evaluate HIV-1 polymerase (pol) gene…”
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Characterisation of HIV-1 reservoirs in paediatric populations: protocol for a systematic review and meta-analysis by Ka’e, Aude Christelle, Nanfack, Aubin, Santoro, Maria-Mercedes, Yagai, Bouba, Ambada, Georgia, Sagnia, Bertrand, Nka, Alex Durand, Ngoufack Jagni Semengue, Ezechiel, Pabo, Willy, Takou, Désiré, Sonela, Nelson, Colizzi, Vittorio, Perno, Carlo-Federico, Ceccherini-Silberstein, Francesca, Lewin, Sharon R, Tiemessen, Caroline T, Fokam, Joseph

“…IntroductionThe success of antiretroviral therapy (ART) has changed HIV from a deadly to a chronic infection, thus increasing the transitioning from infancy…”
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Advancing HIV cure research in low- and middle-income countries requires empowerment of the next generation of scientists by Roger Tatoud, R Brad Jones, Krista Dong, Thumbi Ndung'u, Steven Deeks, Caroline T. Tiemessen

“…While low- and middle-income countries (LMICs), especially in Southern and Eastern Africa, bear the largest burden of the HIV globally, investigators working…”
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The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations by da Rocha, Jorge E B, Othman, Houcemeddine, Botha, Gerrit, Cottino, Laura, Twesigomwe, David, Ahmed, Samah, Drögemöller, Britt I, Fadlelmola, Faisal M, Machanick, Philip, Mbiyavanga, Mamana, Panji, Sumir, Wright, Galen E B, Adebamowo, Clement, Matshaba, Mogomotsi, Ramsay, Michéle, Simo, Gustave, Simuunza, Martin C, Tiemessen, Caroline T, Baldwin, Sandra, Chiano, Mathias, Cox, Charles, Gross, Annette S, Thomas, Pamela, Gamo, Francisco-Javier, Hazelhurst, Scott

“…Investigating variation in genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are key to characterizing pharmacogenomic…”
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Reduced CCR5 Expression and Immune Quiescence in Black South African HIV-1 Controllers by Picton, Anabela C P, Paximadis, Maria, Koor, Gemma W, Bharuthram, Avani, Shalekoff, Sharon, Lassauniere, Ria, Ive, Prudence, Tiemessen, Caroline T

“…Unique Individuals who exhibit either suppressive HIV-1 control, or the ability to maintain low viral load set-points and preserve their CD4+ T cell counts for…”
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Comparison of a quantitative Real-Time PCR assay and droplet digital PCR for copy number analysis of the CCL4L genes by Bharuthram, Avani, Paximadis, Maria, Picton, Anabela C.P., Tiemessen, Caroline T.

“…•CCL4L copy number determination (CND) for two South African populations.•Droplet digital PCR (ddPCR) and Real-Time qPCR for CND were compared.•ddPCR was more…”
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Early antiretroviral treatment of infants to attain HIV remission by Kuhn, Louise, Strehlau, Renate, Shiau, Stephanie, Patel, Faeezah, Shen, Yanhan, Technau, Karl-Günter, Burke, Megan, Sherman, Gayle, Coovadia, Ashraf, Aldrovandi, Grace M., Hazra, Rohan, Tsai, Wei-Yann, Tiemessen, Caroline T., Abrams, Elaine J.

“…Studies in adults and children suggested that starting antiretroviral therapy (ART) soon after infection positively influences early events in HIV infection…”
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Alloimmunity to Class 2 Human Leucocyte Antigens May Reduce HIV-1 Acquisition - A Nested Case-Control Study in HIV-1 Serodiscordant Couples by Suchard, Melinda S, Martinson, Neil, Malfeld, Susan, de Assis Rosa, Debbie, Mackelprang, Romel D, Lingappa, Jairam, Hou, Xuanlin, Rees, Helen, Delany-Moretlwe, Sinead, Goldfein, Hadassa, Ranchod, Heena, Coetzee, David, Otwombe, Kennedy, Morris, Lynn, Tiemessen, Caroline T, Savulescu, Dana M

“…Enveloped viruses, including the Human Immunodeficiency Virus-1 (HIV), incorporate host proteins such as human leucocyte antigens (HLA) into their envelope…”
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Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in mice by Jansen van Vuren, Petrus, Tiemessen, Caroline T, Paweska, Janusz T

“…The known virulence factor of Rift Valley fever virus (RVFV), the NSs protein, counteracts the antiviral effects of the type I interferon response. In this…”
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