Search Results - "Tidwell, R."

Woman With Discolored Fingers by Tidwell, R. David, Louka, Amir

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Human African trypanosomiasis: pharmacological re‐engagement with a neglected disease by Barrett, M P, Boykin, D W, Brun, R, Tidwell, R R

“…This review discusses the challenges of chemotherapy for human African trypanosomiasis (HAT). The few drugs registered for use against the disease are…”
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BMAL1 links the circadian clock to viral airway pathology and asthma phenotypes by Ehlers, A, Xie, W, Agapov, E, Brown, S, Steinberg, D, Tidwell, R, Sajol, G, Schutz, R, Weaver, R, Yu, H, Castro, M, Bacharier, L B, Wang, X, Holtzman, M J, Haspel, J A

“…Patients with asthma experience circadian variations in their symptoms. However it remains unclear how specific aspects of this common airway disease relate to…”
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Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells by Alhourani, Abdelnour H., Tidwell, Tia R., Bokil, Ansooya A., Røsland, Gro V., Tronstad, Karl Johan, Søreide, Kjetil, Hagland, Hanne R.

“…Cancer cells exhibit altered metabolism, a phenomenon described a century ago by Otto Warburg. However, metabolic drug targeting is considered an underutilized…”
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Synthesis and Antiprotozoal Activity of Cationic 1,4-Diphenyl-1H-1,2,3-triazoles by Bakunov, Stanislav A, Bakunova, Svetlana M, Wenzler, Tanja, Ghebru, Maedot, Werbovetz, Karl A, Brun, Reto, Tidwell, Richard R

“…Novel dicationic triazoles 1−60 were synthesized by the Pinner method from the corresponding dinitriles, prepared via the copper(I)-catalyzed azide−alkyne…”
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New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289 by WENZLER, Tanja, BOYKIN, David W, ISMAIL, Mohamed A, HALL, James Edwin, TIDWELL, Richard R, BRUN, Reto

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Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles by Tidwell, Tia R., Røsland, Gro, Tronstad, Karl Johan, Søreide, Kjetil, Hagland, Hanne R.

“…Background In vitro drug screening that is more translatable to the in vivo tumor environment can reduce both time and cost of cancer drug development. Here we…”
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Author Correction: Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells by Alhourani, Abdelnour H., Tidwell, Tia R., Bokil, Ansooya A., Røsland, Gro V., Tronstad, Karl Johan, Søreide, Kjetil, Hagland, Hanne R.

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Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines by Tidwell, Tia R, Røsland, Gro V, Tronstad, Karl Johan, Søreide, Kjetil, Hagland, Hanne R

“…Most in vitro cancer cell experiments have been performed using 2D models. However, 3D spheroid cultures are increasingly favored for being more representative…”
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Randomized, Double-Blinded, Placebo-controlled Multicenter Adaptive Phase 1-2 Trial of GC 4419, a Dismutase Mimetic, in Combination with High Dose Stereotactic Body Radiation Therapy (SBRT) in Locally Advanced Pancreatic Cancer (PC) by Hoffe, S., Frakes, J.M., Aguilera, T.A., Czito, B., Palta, M., Brookes, M., Schweizer, C., Colbert, L., Moningi, S., Bhutani, M.S., Pant, S., Tzeng, C.W., Tidwell, R.S., Thall, P., Yuan, Y., Moser, E.C., Holmlund, J., Herman, J., Taniguchi, C.M.

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In Vitro and In Vivo Trypanosomicidal Action of Novel Arylimidamides against Trypanosoma cruzi by Guedes-da-Silva, F H, Batista, D G J, Meuser, M B, Demarque, K C, Fulco, T O, Araújo, J S, Da Silva, P B, Da Silva, C F, Patrick, D A, Bakunova, S M, Bakunov, S A, Tidwell, R R, Oliveira, G M, Britto, C, Moreira, O C, Soeiro, M N C

“…Arylimidamides (AIAs) have been shown to have considerable biological activity against intracellular pathogens, includingTrypanosoma cruzi, which causes Chagas…”
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Highly Effective Oral Amphotericin B Formulation against Murine Visceral Leishmaniasis by Wasan, Kishor M., Wasan, Ellen K., Gershkovich, Pavel, Zhu, Xiaohua, Tidwell, Richard R., Werbovetz, Karl A., Clement, John G., Thornton, Sheila J.

“…Visceral leishmaniasis is a deadly parasitic disease caused by obligate intramacrophage protozoans of the Leishmania genus. The World Health Organization…”
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The Mitochondrion Is a Site of Trypanocidal Action of the Aromatic Diamidine DB75 in Bloodstream Forms of Trypanosoma brucei by LANTERI, Charlotte A, TIDWELL, Richard R, MESHNICK, Steven R

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Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters by Ming, Xin, Ju, Wujian, Wu, Huali, Tidwell, Richard R, Hall, James E, Thakker, Dhiren R

“…The antiparasitic activity of aromatic diamidine drugs, pentamidine and furamidine, depends on their entry into the pathogenic protozoa via membrane…”
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Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial by Pohlig, Gabriele, Bernhard, Sonja C, Blum, Johannes, Burri, Christian, Mpanya, Alain, Lubaki, Jean-Pierre Fina, Mpoto, Alfred Mpoo, Munungu, Blaise Fungula, N'tombe, Patrick Mangoni, Deo, Gratias Kambau Manesa, Mutantu, Pierre Nsele, Kuikumbi, Florent Mbo, Mintwo, Alain Fukinsia, Munungi, Augustin Kayeye, Dala, Amadeu, Macharia, Stephen, Bilenge, Constantin Miaka Mia, Mesu, Victor Kande Betu Ku, Franco, Jose Ramon, Dituvanga, Ndinga Dieyi, Tidwell, Richard R, Olson, Carol A

“…Sleeping sickness (human African trypanosomiasis [HAT]) is a neglected tropical disease with limited treatment options that currently require parenteral…”
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Synthesis and Antiprotozoal Activity of Dicationic m‑Terphenyl and 1,3-Dipyridylbenzene Derivatives by Patrick, Donald A, Ismail, Mohamed A, Arafa, Reem K, Wenzler, Tanja, Zhu, Xiaohua, Pandharkar, Trupti, Jones, Susan Kilgore, Werbovetz, Karl A, Brun, Reto, Boykin, David W, Tidwell, Richard R

“…4,4″-Diamidino-m-terphenyl (1) and 36 analogues were prepared and assayed in vitro against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Plasmodium…”
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Efficacy of the Novel Diamidine Compound 2,5-Bis(4-Amidinophenyl)- Furan-Bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense Infection in Vervet Monkeys after Oral Administration by Mdachi, R E, Thuita, J K, Kagira, J M, Ngotho, J M, Murilla, G A, Ndung'u, J M, Tidwell, R R, Hall, J E, Brun, R

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Structure-In Vitro Activity Relationships of Pentamidine Analogues and Dication-Substituted Bis-Benzimidazoles as New Antifungal Agents by DEL POETA, M, SCHELL, W. A, PERFECT, J. R, DYKSTRA, C. C, JONES, S, TIDWELL, R. R, CZARNY, A, BAJIC, Miroslav, BAJIC, Marina, KUMAR, A, BOYKIN, D

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Structure‐activity relationships of pentamidine‐affected ion channel trafficking and dofetilide mediated rescue by Varkevisser, R, Houtman, M J C, Linder, T, Git, K C G, Beekman, H D M, Tidwell, R R, IJzerman, A P, Stary‐Weinzinger, A, Vos, M A, Heyden, M A G

“…Background and Purpose Drug interference with normal hERG protein trafficking substantially reduces the channel density in the plasma membrane and thereby…”
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Phenotypic drug discovery for human African trypanosomiasis: A powerful approach by Buckner, Frederick S, Buchynskyy, Andriy, Nagendar, Pendem, Patrick, Donald A, Gillespie, J Robert, Herbst, Zackary, Tidwell, Richard R, Gelb, Michael H

“…The work began with the screening of a library of 700,000 small molecules for inhibitors of 'Trypanosoma brucei' growth (a phenotypic screen). The resulting…”
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