Search Results - "Tidemand, Frederik Grønbæk"
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Travel light: Essential packing for membrane proteins with an active lifestyle
Published in Biochimie (01-02-2023)“…We review the considerable progress during the recent decade in the endeavours of designing, optimising, and utilising carrier particle systems for structural…”
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Structural model of tissue factor (TF) and TF-factor VIIa complex in a lipid membrane: A combined experimental and computational study
Published in Journal of colloid and interface science (01-10-2022)“…[Display omitted] Tissue factor (TF) is a membrane protein involved in blood coagulation. TF initiates a cascade of proteolytic reactions, ultimately leading…”
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3
Structural and Biophysical Properties of Supercharged and Circularized Nanodiscs
Published in Langmuir (08-06-2021)“…Nanodiscs based on membrane scaffold proteins (MSPs) and phospholipids are used as membrane mimics to stabilize membrane proteins in solution for structural…”
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4
Peptide discs as precursors of biologically relevant supported lipid bilayers
Published in Journal of colloid and interface science (01-03-2021)“…[Display omitted] Supported lipid bilayers (SLBs) are commonly used to investigate the structure and dynamics of biological membranes. Vesicle fusion is a…”
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5
Global fitting of multiple data frames from SEC–SAXS to investigate the structure of next‐generation nanodiscs
Published in Acta crystallographica. Section D, Biological crystallography. (01-04-2022)“…The combination of online size‐exclusion chromatography and small‐angle X‐ray scattering (SEC–SAXS) is rapidly becoming a key technique for structural…”
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6
Efficient refolding and reconstitution of tissue factor into nanodiscs facilitates structural investigation of a multicomponent system on a lipid bilayer
Published in Biochimica et biophysica acta. Biomembranes (01-06-2020)“…Structural data on membrane proteins in a lipid membrane environment is challenging to obtain but needed to provide information on the, often essential,…”
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Circularized and solubility‐enhanced MSPs facilitate simple and high‐yield production of stable nanodiscs for studies of membrane proteins in solution
Published in The FEBS journal (01-05-2019)“…Recently, an enzymatic reaction was utilized to covalently link the N and C termini of membrane scaffold proteins to produce circularized nanodiscs that were…”
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8
PSX, Protein–Solvent Exchange: software for calculation of deuterium‐exchange effects in small‐angle neutron scattering measurements from protein coordinates
Published in Journal of applied crystallography (01-12-2019)“…Recent developments in neutron scattering instrumentation and sample handling have enabled studies of more complex biological samples and measurements at…”
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9
Peptide Disc Mediated Control of Membrane Protein Orientation in Supported Lipid Bilayers for Surface-Sensitive Investigations
Published in Analytical chemistry (Washington) (07-01-2020)“…In vitro characterization of membrane proteins requires experimental approaches providing mimics of the microenvironment that proteins encounter in native…”
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10
Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1
Published in The Journal of biological chemistry (13-01-2017)“…Intrinsically disordered protein regions (IDRs) lack a well defined three-dimensional structure but often facilitate key protein functions. Some interactions…”
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11
Dark peptide discs for the investigation of membrane proteins in supported lipid bilayers: the case of synaptobrevin 2 (VAMP2)
Published in Nanoscale advances (25-10-2022)“…Supported lipid bilayers (SLBs) are commonly used as model systems mimicking biological membranes. Recently, we reported a new method to produce SLBs with…”
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12
Mg 2+ -dependent conformational equilibria in CorA and an integrated view on transport regulation
Published in eLife (07-02-2022)“…The CorA family of proteins regulates the homeostasis of divalent metal ions in many bacteria, archaea, and eukaryotic mitochondria, making it an important…”
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13
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Published in eLife (07-02-2022)“…The CorA family of proteins regulates the homeostasis of divalent metal ions in many bacteria, archaea, and eukaryotic mitochondria, making it an important…”
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14
Quantification of Conformational Entropy Unravels Effect of Disordered Flanking Region in Coupled Folding and Binding
Published in Journal of the American Chemical Society (15-09-2021)“…Intrinsic disorder (ID) constitutes a new dimension to the protein structure–function relationship. The ability to undergo conformational changes upon binding…”
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15
Peripherally restricted PICK1 inhibitor mPD5 ameliorates pain behaviors in murine inflammatory and neuropathic pain models
Published in JCI insight (17-09-2024)“…Chronic pain is a complex, debilitating, and escalating health problem worldwide, impacting one in five adults. Current treatment is compromised by…”
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16
Circularized and solubility‐enhanced MSP s facilitate simple and high‐yield production of stable nanodiscs for studies of membrane proteins in solution
Published in The FEBS journal (01-05-2019)“…Recently, an enzymatic reaction was utilized to covalently link the N and C termini of membrane scaffold proteins to produce circularized nanodiscs that were…”
Get full text
Journal Article -
17
Mg.sup.2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
Published in eLife (07-02-2022)“…The CorA family of proteins regulates the homeostasis of divalent metal ions in many bacteria, archaea, and eukaryotic mitochondria, making it an important…”
Get full text
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