Search Results - "Tichacek, Christopher"

Development of Targeted Alpha Particle Therapy for Solid Tumors by Tafreshi, Narges K, Doligalski, Michael L, Tichacek, Christopher J, Pandya, Darpan N, Budzevich, Mikalai M, El-Haddad, Ghassan, Khushalani, Nikhil I, Moros, Eduardo G, McLaughlin, Mark L, Wadas, Thaddeus J, Morse, David L

“…Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-particles (cytotoxic payload) to tumors by chelation to monoclonal…”
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Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment by Zhang, Wei, Oraiqat, Ibrahim, Litzenberg, Dale, Chang, Kai-Wei, Hadley, Scott, Sunbul, Noora Ba, Matuszak, Martha M., Tichacek, Christopher J., Moros, Eduardo G., Carson, Paul L., Cuneo, Kyle C., Wang, Xueding, El Naqa, Issam

“…Ionizing radiation acoustic imaging (iRAI) allows online monitoring of radiation’s interactions with tissues during radiation therapy, providing real-time,…”
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Preclinical evaluation of [225Ac]Ac-DOTA-TATE for treatment of lung neuroendocrine neoplasms by Tafreshi, Narges K., Pandya, Darpan N., Tichacek, Christopher J., Budzevich, Mikalai M., Wang, Zhen, Reff, Jordan N., Engelman, Robert W., Boulware, David C., Chiappori, Alberto A., Strosberg, Jonathan R., Ji, Haitao, Wadas, Thaddeus J., El-Haddad, Ghassan, Morse, David L.

“…Purpose There is significant interest in the development of targeted alpha-particle therapies (TATs) for treatment of solid tumors. The metal chelator-peptide…”
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A Monte Carlo Method for Determining the Response Relationship between Two Commonly Used Detectors to Indirectly Measure Alpha Particle Radiation Activity by Tichacek, Christopher J, Budzevich, Mikalai M, Wadas, Thaddeus J, Morse, David L, Moros, Eduardo G

“…Using targeted ligands to deliver alpha-emitting radionuclides directly to tumor cells has become a promising therapeutic strategy. To calculate the radiation…”
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Melanocortin 1 Receptor-Targeted α-Particle Therapy for Metastatic Uveal Melanoma by Tafreshi, Narges K, Tichacek, Christopher J, Pandya, Darpan N, Doligalski, Michael L, Budzevich, Mikalai M, Kil, HyunJoo, Bhatt, Nikunj B, Kock, Nancy D, Messina, Jane L, Ruiz, Epifanio E, Delva, Nella C, Weaver, Adam, Gibbons, William R, Boulware, David C, Khushalani, Nikhil I, El-Haddad, Ghassan, Triozzi, Pierre L, Moros, Eduardo G, McLaughlin, Mark L, Wadas, Thaddeus J, Morse, David L

“…New effective therapies are greatly needed for metastatic uveal melanoma, which has a very poor prognosis with a median survival of less than 1 y. The…”
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Biodistribution and Multicompartment Pharmacokinetic Analysis of a Targeted α Particle Therapy by Tichacek, Christopher J, Tafreshi, Narges K, Kil, HyunJoo, Engelman, Robert W, Doligalski, Michael L, Budzevich, Mikalai M, Gage, Kenneth L, McLaughlin, Mark L, Wadas, Thaddeus J, Silva, Ariosto, Moros, Eduardo, Morse, David L

“…Targeted α particle therapy (TAT) is ideal for treating disease while minimizing damage to surrounding nontargeted tissues due to short path length and high…”
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434 Ionizing radiation acoustic imaging (iRAI) for volumetric mapping the dose deep in the liver during radiation therapy by Zhang, Wei, Oraiqat, Ibrahim, Litzenberg, Dale, Chang, Kai-Wei, Hadley, Scott, Ba Sunbul, Noora, Matuszak, Martha M., Tichacek, Christopher, Moros, Eduardo G., Carson, Paul L., Cuneo, Kyle C., Wang, Xueding, El Naqa, Issam

“…OBJECTIVES/GOALS: The goal of this study was to develop a clinically applicable technique to increase the precision of in vivo dose monitoring during radiation…”
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Lipophilicity Determines Routes of Uptake and Clearance, and Toxicity of an Alpha-Particle-Emitting Peptide Receptor Radiotherapy by Tafreshi, Narges K, Kil, HyunJoo, Pandya, Darpan N, Tichacek, Christopher J, Doligalski, Michael L, Budzevich, Mikalai M, Delva, Nella C, Langsen, Michael L, Vallas, John A, Boulware, David C, Engelman, Robert W, Gage, Kenneth L, Moros, Eduardo G, Wadas, Thaddeus J, McLaughlin, Mark L, Morse, David L

“…Lipophilicity is explored in the biodistribution (BD), pharmacokinetics (PK), radiation dosimetry (RD), and toxicity of an internally administered targeted…”
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Lipophilicity Determines Route of Clearance of a Melanocortin 1 ReceptorTargeted Radiopharmaceutical by Tafreshi, Narges, Kil, Hyun Joo, Pandya, Darpan, Tichacek, Christopher, Doligalski, Michael, Budzevich, Mikalai, Delva, Nella, Langsen, Michael, Moros, Eduardo, Wadas, Thad, McLaughlin, Mark, Morse, David

“…Objectives: $$table_{DC41E09C-5B53-40FB-B8C5-F2DA933B3139}$$New effective therapies are greatly needed for metastatic uveal melanoma which has a very poor…”
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Abstract 5198: Targeted alpha particle therapy for uveal melanoma by Tafreshi, Narges K., Delva, Nella C., Tichacek, Christopher J., Doligalski, Michael L., Pandya, Darpan N., Bhatt, Nikunj B., Kil, HyunJoo, Budzevich, Mikalai M., Ruiz, Epifanio, Wadas, Thaddeus J., McLaughlin, Mark L., Morse, David L.

“…Abstract New effective therapies are greatly needed for uveal melanoma, the most common ocular malignancy, which has a very poor prognosis with a median…”
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Development of a Voxel-Based Monte Carlo Radiation Dosimetry Methodology for a Targeted Alpha Particle Therapy by Tichacek, Christopher John

“…The use of targeted ligands to deliver radioisotopes directly to tumor cells is a promising therapeutic strategy. Because of the short path length and high LET…”
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WE-FG-BRA-10: Radiodosimetry of a Novel Alpha Particle Therapy Targeted to Uveal Melanoma: Absorbed Dose to Organs in Mice by Tichacek, Christopher J., Tafreshi, Narges K., Budzevich, Mikalai M., Ruiz, Epifanio, Wadas, Thaddeus J., McLaughlin, Mark L., Moros, Eduardo G., L. Morse, David

“…Purpose: The melanocortin-1 receptor (MC1R) is expressed in 94% of uveal melanomas and is described as an ideal target for this untreatable disease. MC1RL is a…”
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