Search Results - "Tibullo, Daniele"
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Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential
Published in Inflammation research (01-11-2017)“…Background The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a variety of biochemical reactions where redox state is…”
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Proteasome Inhibitors as a Possible Therapy for SARS-CoV-2
Published in International journal of molecular sciences (20-05-2020)“…The COVID-19 global pandemic is caused by SARS-CoV-2, and represents an urgent medical and social issue. Unfortunately, there is still not a single proven…”
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The Biochemical and Pharmacological Properties of Ozone: The Smell of Protection in Acute and Chronic Diseases
Published in International journal of molecular sciences (01-02-2019)“…Ozone therapy has been widely used in everyday clinical practice over the last few years, leading to significant clinical results in the treatment of herniated…”
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IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis
Published in International journal of molecular sciences (14-04-2022)“…Insulin-like growth factors binding protein-6 (IGFBP-6) is involved in a relevant number of cellular activities and represents an important factor in the…”
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Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing
Published in Cell death & disease (16-06-2021)“…Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells. In…”
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Skin Mucus of Marine Fish as a Source for the Development of Antimicrobial Agents
Published in Frontiers in Marine Science (18-09-2020)“…Fish skin mucus is an important component of innate immune mechanism and provides a first barrier against pathogens. Although several studies investigated and…”
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The Role of Epigenetics in Neuroinflammatory-Driven Diseases
Published in International journal of molecular sciences (02-12-2022)“…Neurodegenerative disorders are characterized by the progressive loss of central and/or peripheral nervous system neurons. Within this context,…”
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Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype
Published in International journal of molecular sciences (20-12-2022)“…Uveal melanoma (UM), the most common primary intraocular cancer in adults, is among the tumors with poorer prognosis. Recently, the role of the oncometabolite…”
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Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain
Published in International journal of molecular sciences (24-05-2022)“…Chronic neuropathic pain emerges from either central or peripheral lesions inducing spontaneous or amplified responses to non-noxious stimuli. Despite…”
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Heme Oxygenase-1 and Carbon Monoxide Regulate Growth and Progression in Glioblastoma Cells
Published in Molecular neurobiology (01-05-2020)“…In human glioma tumours, heme oxygenase-1 (HO-1) is overexpressed when compared with normal brain tissues and during oligodendroglioma progression. However,…”
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In-vitro NET-osis induced by COVID-19 sera is associated to severe clinical course in not vaccinated patients and immune-dysregulation in breakthrough infection
Published in Scientific reports (04-05-2022)“…Since neutrophil extracellular traps formation (NET-osis) can be assessed indirectly by treating healthy neutrophils with blood-derived fluids from patients…”
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Glioblastoma mesenchymal subtype enhances antioxidant defence to reduce susceptibility to ferroptosis
Published in Scientific reports (05-09-2024)“…Glioblastoma (GBM) represents an aggressive brain tumor, characterized by intra- and inter-tumoral heterogeneity and therapy resistance, leading to…”
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Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies: An Overview
Published in Frontiers in oncology (21-12-2020)“…The combined derangements in mitochondria network, function and dynamics can affect metabolism and ATP production, redox homeostasis and apoptosis triggering,…”
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Resistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients
Published in Scientific reports (27-01-2023)“…Colorectal Cancer (CRC) is one of the most common cancers accounting for 1.8 million new cases worldwide every year. Therefore, the identification of new…”
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CXCL12/CXCR4 axis supports mitochondrial trafficking in tumor myeloma microenvironment
Published in Oncogenesis (New York, NY) (21-01-2022)“…Mesenchymal stromal cells (MSCs) within the protective microenvironment of multiple myeloma (MM) promote tumor growth, confer chemoresistance and support…”
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Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758)
Published in Marine drugs (01-11-2017)“…Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel…”
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Myeloid derived suppressor cells (MDSCs) are increased and exert immunosuppressive activity together with polymorphonuclear leukocytes (PMNs) in chronic myeloid leukemia patients
Published in PloS one (11-07-2014)“…Tumor immune tolerance can derive from the recruitment of suppressor cell population, including myeloid derived suppressor cells (MDSCs), able to inhibit T…”
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Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance
Published in Journal of translational medicine (03-11-2023)“…Abstract Background Follicular thyroid cancer (FTC) is a prevalent form of differentiated thyroid cancer, whereas anaplastic thyroid cancer (ATC) represents a…”
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Nuclear translocation of heme oxygenase-1 confers resistance to imatinib in chronic myeloid leukemia cells
Published in Current pharmaceutical design (01-05-2013)“…Identification of imatinib mesylate as a potent inhibitor of the Abl kinase and the subsequent findings that this compound displays growth inhibitory and…”
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Evaluation of Chronic Nanosilver Toxicity to Adult Zebrafish
Published in Frontiers in physiology (14-12-2017)“…Nanotechnology is rapidly growing with nanoparticles produced and utilized in a wide range of commercial products worldwide. Among the different types of…”
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