Search Results - "Tibbitts, J."

Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions by Qureshi, O. S., Rowley, T. F., Junker, F., Peters, S. J., Crilly, S., Compson, J., Eddleston, A., Björkelund, H., Greenslade, K., Parkinson, M., Davies, N. L., Griffin, R., Pither, T. L., Cain, K., Christodoulou, L., Staelens, L., Ward, E., Tibbitts, J., Kiessling, A., Smith, B., Brennan, F. R., Malmqvist, M., Fallah-Arani, F., Humphreys, D. P.

“…Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of…”
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Semi-mechanistic Population Pharmacokinetic Model of Multivalent Trastuzumab Emtansine in Patients with Metastatic Breast Cancer by Chudasama, V L, Schaedeli Stark, F, Harrold, J M, Tibbitts, J, Girish, S R, Gupta, M, Frey, N, Mager, D E

“…Trastuzumab emtansine (T‐DM1) is an antibody–drug conjugate (ADC) composed of multiple molecules of the antimicrotubule agent DM1 linked to trastuzumab, a…”
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Attenuated Salmonella enterica Serovar Typhi Expressing Urease Effectively Immunizes Mice against Helicobacter pylori Challenge as Part of a Heterologous Mucosal Priming-Parenteral Boosting Vaccination Regimen by LONDONO-ARCILA, Patricia, FREEMAN, Donna, DARSLEY, Michael J, KLEANTHOUS, Harry, O'DOWD, Aisling M, LEWIS, Susan, TURNER, Arthur K, REES, Emma L, TIBBITTS, Timothy J, GREENWOOD, Judith, MONATH, Thomas P

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Rectal and intranasal immunizations with recombinant urease induce distinct local and serum immune responses in mice and protect against Helicobacter pylori infection by KLEANTHOUS, H, MYERS, G. A, LEE, C. K, ERMAK, T. H, MONATH, T. P, GEORGAKOPOULOS, K. M, TIBBITTS, T. J, INGRASSIA, J. W, GRAY, H. L, RU DING, ZHANG, Z.-Z, WENDE LEI, NICHOLS, R

“…To determine the optimal inductive sites for immunization against Helicobacter pylori infection, the protective efficacy of recombinant urease (rUre) was…”
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Vulnerability of mouse cortical neurons to doxorubicin-induced apoptosis is strain-dependent and is correlated with mRNAs encoding Fas, Fas-Ligand, and metalloproteinases by Wetzel, M, Tibbitts, J, Rosenberg, G A, Cunningham, L A

“…Cell surface death receptor-mediated neuronal apoptosis, which is a critical component of neurodegeneration, is modulated by matrix metalloproteinases (MMPs)…”
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86 Potent anti-tumor activity of T-DM1 antibody–drug conjugate in combination with chemotherapeutic agents in breast tumor cells by Parsons, K, Fields, C, Gunter, B, Phillips, G, Tibbitts, J

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Sterilizing immunity against experimental Helicobacter pylori infection is challenge-strain dependent by Kleanthous, Harry, Tibbitts, Timothy J, Gray, Heather L, Myers, Gwendolyn A, Lee, Cynthia K, Ermak, Thomas H, Monath, Thomas P

“…The development of a murine model of Helicobacter pylori infection through serial in vivo passage of candidate strains has enabled a quantitative assessment of…”
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237 Mechanistic pharmacokinetic/pharmacodynamic (PK/PD) modeling of xenograft tumor response of Trastuzumab-DM1-antibody drug conjugates by Wada, R, Erickson, H.K, Phillips, G. Lewis, Provenzano, C.A, Leipold, D.D, Pinkas, J, Mai, E, Gupta, M, Johnson, H, Tibbitts, J

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2118 POSTER A phase I study of trastuzumab-DM1, a first-in-class HER2 antibody-drug conjugate, in patients with HER2+ metastatic breast cancer by Krop, I.E, Beeram, M, Modi, S, Rabbee, N, Girish, S, Tibbitts, J, Holden, S.N, Lutzker, S.G, Burris, H.A

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Risk of Helicobacter pylori infection among long-term residents in developing countries by Becker, S I, Smalligan, R D, Frame, J D, Kleanthous, H, Tibbitts, T J, Monath, T P, Hyams, K C

“…The seroprevalence and incidence of Helicobacter pylori infection were determined among 312 North American missionaries who were serving in developing…”
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P023 SZN-1326, a Wnt agonist, improved epithelial healing and ameliorated colitis in a chronic DSS model, in stark contrast to anti-TNF and anti-IL-12/23p40 antibodies by Xie, L, Handa, P, Tun, C, Liu, A, Lu, C, Baribault, H, Newman, M, Le, L, Shah, D, Deshmukh, S, Mutha, D, Le, T, Fletcher, R, Chen, H, Ye, J, Tibbitts, J, Srinivasan, U, Li, Y, Vanhove, G, Yeh, W C

“…Abstract Background All currently approved treatments for Inflammatory bowel disease (IBD) and the majority of drugs in the pipeline are anti-inflammatory…”
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P016 SZN-1326, a Wnt signal activator, is more efficacious than cyclosporine A in an acute DSS model by Xie, L, Baribault, H, Lu, C, Handa, P, Newman, M, Le, L, Liu, A, Mutha, D, Deshmukh, S, Shah, D, Tun, C, Le, T, Fletcher, R, Chen, H, Ye, J, Tibbitts, J, Srinivasan, U, Li, Y, Vanhove, G, Yeh, W C

“…Abstract Background Current Inflammatory bowel disease (IBD) treatments focus on inhibition of excessive inflammation, and clinical remission rates have…”
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Issues related to the use of canines in toxicologic pathology: Issues with pharmacokinetics and metabolism by TIBBITTS, Jay

“…The dog is a commonly used animal model by virtue of its size, well-characterized physiology, and ease of handling. For these reasons and others, dogs are also…”
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Semi-mechanistic Population Pharmacokinetic Model of MultivalentTrastuzumab Emtansine in Patients with Metastatic Breast Cancer: INDIVIDUALIZATION by CHUDASAMA, V. L, SCHAEDELI STARK, F, HARROLD, J. M, TIBBITTS, J, GIRISH, S. R, GUPTA, M, FREY, N, MAGER, D. E

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A phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients with advanced HER2+ breast cancer by Krop, IE, Mita, M, Burris, HA, Birkner, M, Girish, S, Tibbitts, J, Holden, SN, Lutzker, SG, Modi, S

“…Abstract Abstract #3136 Background: T-DM1, a novel HER2 antibody-drug conjugate (ADC) in development for HER2+ breast cancer (BC), combines activity of…”
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Competition in California: the new wave from the West by Tibbitts, S J

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A phase I study of trastuzumab-MCC-DM1 (T-DM1), a first-in-class HER2 antibody-drug conjugate (ADC), in patients (pts) with HER2+ metastatic breast cancer (BC) by Beeram, M., Krop, I., Modi, S., Tolcher, A., Rabbee, N., Girish, S., Tibbitts, J., Holden, S., Lutzker, S., Burris, H.

“…Abstract only 1042 Background: ADCs utilize tumor-specific and/or over-expressed surface antigens that undergo internalization to deliver highly potent…”
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A phase I study of trastuzumab-DM1 (T-DM1), a first-in-class HER2 antibody-drug conjugate (ADC), in patients (pts) with advanced HER2+ breast cancer (BC) by Beeram, M., Burris, H. A., Modi, S., Birkner, M., Girish, S., Tibbitts, J., Holden, S. N., Lutzker, S. G., Krop, I. E.

“…Abstract only…”
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A phase I study of weekly dosing of trastuzumab-DM1 (T-DM1) in patients (pts) with advanced HER2+ breast cancer (BC) by Holden, S. N., Beeram, M., Krop, I. E., Burris, H. A., Birkner, M., Girish, S., Tibbitts, J., Lutzker, S. G., Modi, S.

“…Abstract only…”
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Fantastic reality by Tibbitts, S J

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