Search Results - "Tibbitt, Mark"

Supramolecular engineering of hydrogels for drug delivery by Bernhard, Stéphane, Tibbitt, Mark W.

“…[Display omitted] Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet…”
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Emerging Frontiers in Drug Delivery by Tibbitt, Mark W, Dahlman, James E, Langer, Robert

“…Medicine relies on the use of pharmacologically active agents (drugs) to manage and treat disease. However, drugs are not inherently effective; the benefit of…”
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Linking Molecular Behavior to Macroscopic Properties in Ideal Dynamic Covalent Networks by Marco-Dufort, Bruno, Iten, Ramon, Tibbitt, Mark W

“…Dynamic covalent networks (DCvNs) are increasingly used in advanced materials design with applications ranging from recyclable thermosets to self-healing…”
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Additive Manufacturing of Precision Biomaterials by Guzzi, Elia A., Tibbitt, Mark W.

“…Biomaterials play a critical role in modern medicine as surgical guides, implants for tissue repair, and as drug delivery systems. The emerging paradigm of…”
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Mechanical memory and dosing influence stem cell fate by Yang, Chun, Tibbitt, Mark W., Basta, Lena, Anseth, Kristi S.

“…We investigated whether stem cells remember past physical signals and whether these can be exploited to dose cells mechanically. We found that the activation…”
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Hydrogels as extracellular matrix mimics for 3D cell culture by Tibbitt, Mark W, Anseth, Kristi S

“…Methods for culturing mammalian cells ex vivo are increasingly needed to study cell and tissue physiology and to grow replacement tissue for regenerative…”
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Dynamic and reconfigurable materials from reversible network interactions by Webber, Matthew J., Tibbitt, Mark W.

“…Polymer materials provide solutions to some of the most pressing environmental, manufacturing and health-care challenges. Traditional thermoplastic and…”
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Living Biomaterials by Tibbitt, Mark W, Langer, Robert

“…Convergent advances in the fields of synthetic chemistry, soft matter, molecular self-assembly, and the -omics era point to a new generation of synthetic…”
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Ultrasmall Silica-Based Bismuth Gadolinium Nanoparticles for Dual Magnetic Resonance–Computed Tomography Image Guided Radiation Therapy by Detappe, Alexandre, Thomas, Eloise, Tibbitt, Mark W, Kunjachan, Sijumon, Zavidij, Oksana, Parnandi, Nishita, Reznichenko, Elizaveta, Lux, François, Tillement, Olivier, Berbeco, Ross

“…Selective killing of cancer cells while minimizing damage to healthy tissues is the goal of clinical radiation therapy. This therapeutic ratio can be improved…”
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Environment Controls Biomolecule Release from Dynamic Covalent Hydrogels by Marco-Dufort, Bruno, Willi, Jack, Vielba-Gomez, Felipe, Gatti, Francesco, Tibbitt, Mark W

“…Moldable hydrogels composed of dynamic covalent bonds are attractive biomaterials for controlled release, as the dynamic exchange of bonds in these networks…”
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Universal Nanocarrier Ink Platform for Biomaterials Additive Manufacturing by Guzzi, Elia A., Bovone, Giovanni, Tibbitt, Mark W.

“…Ink engineering is a fundamental area of research within additive manufacturing (AM) that designs next‐generation biomaterials tailored for additive processes…”
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Engineering Hydrogel Adhesion for Biomedical Applications via Chemical Design of the Junction by Bovone, Giovanni, Dudaryeva, Oksana Y, Marco-Dufort, Bruno, Tibbitt, Mark W

“…Hydrogel adhesion inherently relies on engineering the contact surface at soft and hydrated interfaces. Upon contact, adhesion normally occurs through the…”
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Injectable Biocompatible Hydrogels from Cellulose Nanocrystals for Locally Targeted Sustained Drug Release by Bertsch, Pascal, Schneider, Livia, Bovone, Giovanni, Tibbitt, Mark W, Fischer, Peter, Gstöhl, Stefan

“…Injectable hydrogels from biocompatible materials are in demand for tissue engineering and drug delivery systems. Here, we produce hydrogels from mere…”
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Progress in material design for biomedical applications by Tibbitt, Mark W, Christopher B. Rodell, Jason A. Burdick, Kristi S. Anseth

“…Biomaterials that interface with biological systems are used to deliver drugs safely and efficiently; to prevent, detect, and treat disease; to assist the body…”
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Dynamic microenvironments: the fourth dimension by Tibbitt, Mark W, Anseth, Kristi S

“…The extracellular space, or cell microenvironment, choreographs cell behavior through myriad controlled signals, and aberrant cues can result in dysfunction…”
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Solvent Controls Nanoparticle Size during Nanoprecipitation by Limiting Block Copolymer Assembly by Bovone, Giovanni, Cousin, Lucien, Steiner, Fabian, Tibbitt, Mark W.

“…Control of the properties of nanoparticles (NPs), including size, is critical for their application in biomedicine and engineering. Polymeric NPs are commonly…”
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Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms by Anseth, Kristi S, Kloxin, April M, Tibbitt, Mark W

“…We describe a detailed procedure to create photolabile, polyethylene glycol (PEG)-based hydrogels and manipulate material properties in situ . The…”
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Supramolecular Reinforcement of Polymer–Nanoparticle Hydrogels for Modular Materials Design by Bovone, Giovanni, Guzzi, Elia A., Bernhard, Stéphane, Weber, Tim, Dranseikiene, Dalia, Tibbitt, Mark W.

“…Moldable hydrogels are increasingly used as injectable or extrudable materials in biomedical and industrial applications owing to their ability to flow under…”
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Injectable Polymer–Nanoparticle Hydrogels for Local Immune Cell Recruitment by Fenton, Owen S, Tibbitt, Mark W, Appel, Eric A, Jhunjhunwala, Siddharth, Webber, Matthew J, Langer, Robert

“…The ability to engineer immune function has transformed modern medicine, highlighted by the success of vaccinations and recent efforts in cancer immunotherapy…”
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Transplantation of a human liver following 3 days of ex situ normothermic preservation by Clavien, Pierre-Alain, Dutkowski, Philipp, Mueller, Matteo, Eshmuminov, Dilmurodjon, Bautista Borrego, Lucia, Weber, Achim, Muellhaupt, Beat, Sousa Da Silva, Richard X., Burg, Brian R., Rudolf von Rohr, Philipp, Schuler, Martin J., Becker, Dustin, Hefti, Max, Tibbitt, Mark W.

“…Current organ preservation methods provide a narrow window (usually <12 hours) to assess, transport and implant donor grafts for human transplantation. Here we…”
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