Search Results - "Tianfeng, Xu"

Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer by Han, Xin, Wang, Chao, Qin, Chong, Xiang, Weiguo, Fernandez-Salas, Ester, Yang, Chao-Yie, Wang, Mi, Zhao, Lijie, Xu, Tianfeng, Chinnaswamy, Krishnapriya, Delproposto, James, Stuckey, Jeanne, Wang, Shaomeng

“…We report herein the discovery of highly potent PROTAC degraders of androgen receptor (AR), as exemplified by compound 34 (ARD-69). ARD-69 induces degradation…”
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Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy by Gao, Jing, Hou, Bo, Zhu, Qiwen, Yang, Lei, Jiang, Xingyu, Zou, Zhifeng, Li, Xutong, Xu, Tianfeng, Zheng, Mingyue, Chen, Yi-Hung, Xu, Zhiai, Xu, Huixiong, Yu, Haijun

“…PROteolysis TArgeting Chimeras (PROTACs) has been exploited to degrade putative protein targets. However, the antitumor performance of PROTACs is impaired by…”
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A cooperative DDoS attack detection scheme based on entropy and ensemble learning in SDN by Yu, Shanshan, Zhang, Jicheng, Liu, Ju, Zhang, Xiaoqing, Li, Yafeng, Xu, Tianfeng

“…In order to solve the problem of distributed denial of service (DDoS) attack detection in software-defined network, we proposed a cooperative DDoS attack…”
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Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations by Zhou, Chuan, Fan, Zisheng, Zhou, Zehui, Li, Yupeng, Cui, Rongrong, Liu, Chaoyi, Zhou, Guizhen, Diao, Xingxing, Jiang, Hualiang, Zheng, Mingyue, Zhang, Sulin, Xu, Tianfeng

“…Regulating SOS1 functions may result in targeted pan-KRAS therapies. Small-molecule SOS1 inhibitors showed promising anticancer potential, and the most…”
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Preoperative preparation for Graves’ disease by Xu, Tianfeng, Zheng, Xun, Wei, Tao

“…Thyroidectomy is always regarded as the crucial treatment for Graves’ disease, especially in cases of poor efficacy or excessive side effects of antithyroid-…”
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Incidental synchronous intrathyroidal parathyroid carcinomas and papillary thyroid microcarcinoma with compressive neck mass and primary hyperparathyroidism: case report and literature review by Xu, Tianfeng, Zheng, Xun, Wei, Tao

“…Parathyroid carcinoma (PC) is a rare malignancy, often diagnosed incidentally through postoperative pathological examination. The occurrence of nodular goiter,…”
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Author Correction: Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy by Gao, Jing, Hou, Bo, Zhu, Qiwen, Yang, Lei, Jiang, Xingyu, Zou, Zhifeng, Li, Xutong, Xu, Tianfeng, Zheng, Mingyue, Chen, Yi-Hung, Xu, Zhiai, Xu, Huixiong, Yu, Haijun

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Beyond the Square knot: A validation study for a novel knot-tying method named “inverse 9” by Qin, Xiangquan, Han, Ying, Feng, Yu, Zhou, Jiao, Guo, Siqi, Xu, Tianfeng, Pu, Dan

“…We compared the “inverse 9” laparoscopic suturing and knot-tying (LSKT) method to the traditional LSKT method in a validation study to demonstrate the “inverse…”
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Coot Algorithm for Optimal Carbon–Energy Combined Flow of Power Grid With Aluminum Plants by Qin, Liangdong, Xu, Tianfeng, Li, Sheng, Chen, Zhiyong, Zhang, Qianmao, Tian, Jiahui, Lin, Yujun

“…To achieve a low-carbon and economical operation for the power grid, this paper proposes a novel optimal carbon–energy combined flow (OCECF) by considering the…”
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Corrigendum: Coot Algorithm for Optimal Carbon–Energy Combined Flow of Power Grid With Aluminum Plants by Qin, Liangdong, Xu, Tianfeng, Li, Sheng, Chen, Zhiyong, Zhang, Qianmao, Tian, Jiahui, Lin, Yujun

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Productive and metabolic increments of the inclusion of Broussonetia papyrifera to replace maize silage in growing goats by Hua, Jinling, Xu, Tianfeng, Shen, Quanwen, Liu, Yan, Huang, Guijuan, Rao, Dejian, Song, Chunming, Wang, Jiakun

“…The study was conducted to investigate the effects of Broussonetia papyrifera (BP) on growth performance, rumen fermentation, digestion and meat quality in…”
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Detection of chlorpyrifos in apples using gold nanoparticles based on surface enhanced Raman spectroscopy by Chen, Zhai, Yongyu, Li, Yankun, Peng, Tianfeng, Xu

“…In this study, gold nanoparticles (AuNPs) were synthesized for rapid and sensitive characterization and quantification of chlorpyrifos in apples. Min-max…”
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Study on Establishment of Prognostics and Health Management System for Vessels by Chaowei, Wang, Guojin, Zhou, Boren, Chen, Tianfeng, Xu

“…Difficulties are being brought to maintenance support of vessels along with the continuous improvement in degrees of intelligence, information-based…”
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Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands by Han, Xin, Zhao, Lijie, Xiang, Weiguo, Qin, Chong, Miao, Bukeyan, Xu, Tianfeng, Wang, Mi, Yang, Chao-Yie, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Wang, Shaomeng

“…Androgen receptor (AR) is a validated therapeutic target for the treatment of metastatic castration-resistant prostate cancer (mCRPC). We report herein our…”
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A prospective study comparing the gasless endoscopic thyroidectomy trans-axillary approach to conventional open thyroidectomy: health and quality of life outcomes by Xu, Tianfeng, Qin, Xiangquan, Zhang, Yujie, Li, Pengyu, Ran, Yanhao, Fan, Yuanyuan, Zheng, Xun, Wei, Tao

“…Background The relationship between different surgical treatments and quality of life remains uncertain for differentiated thyroid carcinoma (DTC). The aim of…”
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Copper-Catalyzed Tandem Reactions of 1-(2-Iodoary)-2-yn-1-ones with Isocyanides for the Synthesis of 4-Oxo-indeno[1,2-b]pyrroles by Cai, Qian, Zhou, Fengtao, Xu, Tianfeng, Fu, Liangbing, Ding, Ke

“…A novel copper-catalyzed tandem reaction of 1-(2-iodoaryl)-2-yn-1-ones with isocyanides is described. The reaction is through a formal [3 + 2]…”
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Research on Comprehensive Evaluation of Distribution Network considering Resilience by Jin, Xianing, Song, Yi, Xu, Tianfeng, Yang, Weihong, Yang, Bo

“…With the development of smart distribution network, distributed energy and diversified load are more and more involved in distribution network planning and…”
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Sensitivities evaluation of five radiopharmaceuticals in four common medullary thyroid carcinoma metastatic sites on PET/CT: a network meta-analysis and systematic review by Li, Pengyu, Zhang, Yujie, Xu, Tianfeng, Zhu, Jingqiang, Wei, Tao, Zhao, Wanjun

“…Objectives Detecting medullary thyroid carcinoma (MTC) metastatic lesions accurately is still a challenge for clinicians. PET/computed tomography (PET/CT)…”
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Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting Del19/T790M/C797S Mutation by Zhang, Hualin, Xie, Ruliang, AI-furas, Hawaa, Li, Yupeng, Wu, Qingxia, Li, Jian, Xu, Fang, Xu, Tianfeng

“…The tertiary epidermal growth factor receptor (EGFR) C797S mutation predominates in the acquired mutational resistance in cancer patients to third-generation…”
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Discovery of M‑808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong In Vivo Antitumor Activity by Xu, Shilin, Aguilar, Angelo, Huang, Liyue, Xu, Tianfeng, Zheng, Ke, McEachern, Donna, Przybranowski, Sally, Foster, Caroline, Zawacki, Kaitlin, Liu, Zhaomin, Chinnaswamy, Krishnapriya, Stuckey, Jeanne, Wang, Shaomeng

“…Targeting the menin–MLL protein–protein interaction is a new therapeutic strategy for the treatment of acute leukemia carrying MLL fusion (MLL leukemia). We…”
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