Noncanonical functions of microRNAs in the nucleus

MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with fur...

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Bibliographic Details
Published in:	Acta biochimica et biophysica Sinica Vol. 56; no. 2; pp. 151 - 161
Main Authors:	Gu, Jiayi, Li, Yuanan, Tian, Youtong, Zhang, Yehao, Cheng, Yongjun, Tang, Yuanjia
Format:	Journal Article
Language:	English
Published:	China Oxford University Press 03-01-2024 China Science Publishing & Media Ltd
Subjects:	Cytoplasm - genetics Cytoplasm - metabolism Gene Expression Regulation gene regulation microRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA-inducing silencing complex (miRISC) nuclear localization transcriptional control miRNA-inducing silencing complex (miRISC) nuclear localization microRNA transcriptional control gene regulation
Online Access:	Get full text
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Summary:	MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by inducing target mRNA degradation. However, with further research, evidence shows that mature miRNAs also exist in the cell nucleus, where they can impact gene transcription and ncRNA maturation in several ways. This review provides an overview of novel models of nuclear miRNA functions. Some of the models remain to be verified by experimental evidence, and more details of the miRNA regulation network remain to be discovered in the future.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1672-9145 1745-7270
DOI:	10.3724/abbs.2023268