Search Results - "Tian, Xixi"

Abnormal Termination of Ca2+ Release Is a Common Defect of RyR2 Mutations Associated With Cardiomyopathies by Tang, Yijun, Tian, Xixi, Wang, Ruiwu, Fill, Michael, Chen, S.R Wayne

“…RATIONALE:Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been associated with both cardiac arrhythmias and cardiomyopathies. It is…”
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The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias by Chen, Wenqian, Wang, Ruiwu, Chen, Biyi, Zhong, Xiaowei, Kong, Huihui, Bai, Yunlong, Zhou, Qiang, Xie, Cuihong, Zhang, Jingqun, Guo, Ang, Tian, Xixi, Jones, Peter P, O'Mara, Megan L, Liu, Yingjie, Mi, Tao, Zhang, Lin, Bolstad, Jeff, Semeniuk, Lisa, Cheng, Hongqiang, Zhang, Jianlin, Chen, Ju, Tieleman, D Peter, Gillis, Anne M, Duff, Henry J, Fill, Michael, Song, Long-Sheng, Chen, S R Wayne

“…In heart muscle cells, sarcoplasmic reticulum calcium overload leads to spontaneous calcium waves that can cause arrhythmias and sudden cardiac death. S.R…”
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Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+ Release by Søndergaard, Mads T., Tian, Xixi, Liu, Yingjie, Wang, Ruiwu, Chazin, Walter J., Chen, S.R. Wayne, Overgaard, Michael T.

“…The intracellular Ca2+ sensor calmodulin (CaM) regulates the cardiac Ca2+ release channel/ryanodine receptor 2 (RyR2), and mutations in CaM cause arrhythmias…”
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Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release by Zhou, Qiang, Xiao, Jianmin, Jiang, Dawei, Wang, Ruiwu, Vembaiyan, Kannan, Wang, Aixia, Smith, Chris D, Xie, Cuihong, Chen, Wenqian, Zhang, Jingqun, Tian, Xixi, Jones, Peter P, Zhong, Xiaowei, Guo, Ang, Chen, Haiyan, Zhang, Lin, Zhu, Weizhong, Yang, Dongmei, Li, Xiaodong, Chen, Ju, Gillis, Anne M, Duff, Henry J, Cheng, Heping, Feldman, Arthur M, Song, Long-Sheng, Fill, Michael, Back, Thomas G, Chen, S R Wayne

“…The widely prescribed beta blocker carvedilol has strong antiarrhythmic effects on the heart, but the underlying mechanisms have been unclear. Qiang Zhou et al…”
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Cellular interplay via cytokine hierarchy causes pathological cardiac hypertrophy in RAF1-mutant Noonan syndrome by Yin, Jiani C., Platt, Mathew J., Tian, Xixi, Wu, Xue, Backx, Peter H., Simpson, Jeremy A., Araki, Toshiyuki, Neel, Benjamin G.

“…Noonan syndrome (NS) is caused by mutations in RAS/ERK pathway genes, and is characterized by craniofacial, growth, cognitive and cardiac defects. NS patients…”
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Localization of the Dantrolene-binding Sequence near the FK506-binding Protein-binding Site in the Three-dimensional Structure of the Ryanodine Receptor by Wang, Ruiwu, Zhong, Xiaowei, Meng, Xing, Koop, Andrea, Tian, Xixi, Jones, Peter P., Fruen, Bradley R., Wagenknecht, Terence, Liu, Zheng, Chen, S.R. Wayne

“…Dantrolene is believed to stabilize interdomain interactions between the NH2-terminal and central regions of ryanodine receptors by binding to the NH2-terminal…”
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Removal of FKBP12.6 Does Not Alter the Conductance and Activation of the Cardiac Ryanodine Receptor or the Susceptibility to Stress-induced Ventricular Arrhythmias by Xiao, Jianmin, Tian, Xixi, Jones, Peter P., Bolstad, Jeff, Kong, Huihui, Wang, Ruiwu, Zhang, Lin, Duff, Henry J., Gillis, Anne M., Fleischer, Sidney, Kotlikoff, Michael, Copello, Julio A., Chen, S. R. Wayne

“…The 12.6-kDa FK506-binding protein (FKBP12.6) is considered to be a key regulator of the cardiac ryanodine receptor (RyR2), but its precise role in RyR2…”
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Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor by Liu, Zheng, Wang, Ruiwu, Tian, Xixi, Zhong, Xiaowei, Gangopadhyay, Jaya, Cole, Richard, Ikemoto, Noriaki, Chen, S.R. Wayne, Wagenknecht, Terence

“…Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have been linked to certain types of cardiac arrhythmias and sudden death. Two mutation…”
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Functional Consequence of Protein Kinase A-dependent Phosphorylation of the Cardiac Ryanodine Receptor by Xiao, Bailong, Tian, Xixi, Xie, Wenjun, Jones, Peter P., Cai, Shitian, Wang, Xianhua, Jiang, Dawei, Kong, Huihui, Zhang, Lin, Chen, Keyun, Walsh, Michael P., Cheng, Heping, Chen, S.R. Wayne

“…The phosphorylation of the cardiac Ca2+-release channel (ryanodine receptor, RyR2) by protein kinase A (PKA) has been extensively characterized, but its…”
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Efficacy and safety of apatinib plus immune checkpoint inhibitors and transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma by Wu, Jianfei, Bai, Xuefeng, Yu, Guodong, Zhang, Quan, Tian, Xixi, Wang, Yuan

“…Purpose The evidence of apatinib plus immune checkpoint inhibitors (ICIs) and transarterial chemoembolization (TACE) for treating advanced hepatocellular…”
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Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma by Tian, Xixi, Zhang, Shengzheng, Zhang, Qiong, Kang, Licheng, Ma, Changzhen, Feng, Lifeng, Li, Shengyu, Li, Jing, Yang, Liang, Liu, Jie, Qi, Zhi, Shen, Yanna

“…Renal cell carcinoma (RCC) is one of the most common urologic malignant tumors. Current chemotherapy is not effective in RCC and results in some side effects…”
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The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor by Søndergaard, Mads Toft, Liu, Yingjie, Larsen, Kamilla Taunsig, Nani, Alma, Tian, Xixi, Holt, Christian, Wang, Ruiwu, Wimmer, Reinhard, Van Petegem, Filip, Fill, Michael, Chen, S.R. Wayne, Overgaard, Michael Toft

“…A number of point mutations in the intracellular Ca2+-sensing protein calmodulin (CaM) are arrhythmogenic, yet their underlying mechanisms are not clear. These…”
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Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release by Tian, Xixi, Tang, Yijun, Liu, Yingjie, Wang, Ruiwu, Chen, S R Wayne

“…RyR2 (cardiac ryanodine receptor)-mediated Ca2+ release in cardiomyocytes terminates when the sarcoplasmic reticulum Ca2+ content depletes to a threshold…”
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Spleen tyrosine kinase‑induced JNK‑dependent NLRP3 activation is involved in diabetic cardiomyopathy by Li, Shengyu, Liu, Ruiqing, Xue, Meiting, Qiao, Yingchun, Chen, Yufeng, Long, Guangfeng, Tian, Xixi, Hu, Yahui, Zhou, Pengfei, Dong, Xiaohui, Qi, Zhi, Cui, Yujie, Shen, Yanna

“…Diabetic cardiomyopathy (DCM) is a leading contributor to the increased morbidity and mortality rates associated with diabetes. Persistent inflammation has…”
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The Cytoplasmic Region of Inner Helix S6 Is an Important Determinant of Cardiac Ryanodine Receptor Channel Gating by Sun, Bo, Guo, Wenting, Tian, Xixi, Yao, Jinjing, Zhang, Lin, Wang, Ruiwu, Chen, S. R. Wayne

“…The ryanodine receptor (RyR) channel pore is formed by four S6 inner helices, with its intracellular gate located at the S6 helix bundle crossing region. The…”
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Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca2+ Release and Cardiac Contractility, Independently of L-Type Ca2+ Current by Beca, Sanja, Helli, Peter B, Simpson, Jeremy A, Zhao, Dongling, Farman, Gerrie P, Jones, Peter P, Tian, Xixi, Wilson, Lindsay S, Ahmad, Faiyaz, Chen, S.R Wayne, Movsesian, Matthew A, Manganiello, Vincent, Maurice, Donald H, Conti, Marco, Backx, Peter H

“…RATIONALE:Baseline contractility of mouse hearts is modulated in a phosphatidylinositol 3-kinase-γ–dependent manner by type 4 phosphodiesterases (PDE4), which…”
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Spleen tyrosine kinase promotes NLR family pyrin domain containing 3 inflammasome-mediated IL-1[beta] secretion via c-Jun N-terminal kinase activation and cell apoptosis during diabetic nephropathy by Qiao, Yingchun, Tian, Xixi, Men, Li, Li, Shengyu, Chen, Yufeng, Xue, Meiting, Hu, Yahui, Zhou, Pengfei, Long, Guangfeng, Shi, Yue, Liu, Ruiqing, Liu, Yunde, Qi, Zhi, Cui, Yujie, Shen, Yanna

“…Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin…”
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The CPVT-associated RyR2 mutation G230C enhances store overload-induced Ca2+ release and destabilizes the N-terminal domains by Liu, Yingjie, Kimlicka, Lynn, Hiess, Florian, Tian, Xixi, Wang, Ruiwu, Zhang, Lin, Jones, Peter P, Van Petegem, Filip, Chen, S R Wayne

“…CPVT (catecholaminergic polymorphic ventricular tachycardia) is an inherited life-threatening arrhythmogenic disorder. CPVT is caused by DADs (delayed…”
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Ligand-Dependent Conformational Changes in the Cardiac Ryanodine Receptor by Liu, Yingjie, Tian, Xixi, Wang, Ruiwu, Wagenknecht, Terence, Liu, Zheng, Wayne Chen, Suirong

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Ligand-dependent Conformational Changes in the Clamp Region of the Cardiac Ryanodine Receptor by Tian, Xixi, Liu, Yingjie, Liu, Ying, Wang, Ruiwu, Wagenknecht, Terence, Liu, Zheng, Chen, S.R. Wayne

“…Global conformational changes in the three-dimensional structure of the Ca2+ release channel/ryanodine receptor (RyR) occur upon ligand activation. A number of…”
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