Search Results - "Tiambeng, Timothy N"

Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum by Tiambeng, Timothy N., Roberts, David S., Brown, Kyle A., Zhu, Yanlong, Chen, Bifan, Wu, Zhijie, Mitchell, Stanford D., Guardado-Alvarez, Tania M., Jin, Song, Ge, Ying

“…Top-down mass spectrometry (MS)-based proteomics provides a comprehensive analysis of proteoforms to achieve a proteome-wide understanding of protein…”
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Structure and dynamics of endogenous cardiac troponin complex in human heart tissue captured by native nanoproteomics by Chapman, Emily A., Roberts, David S., Tiambeng, Timothy N., Andrews, Jãán, Wang, Man-Di, Reasoner, Emily A., Melby, Jake A., Li, Brad H., Kim, Donguk, Alpert, Andrew J., Jin, Song, Ge, Ying

“…Protein complexes are highly dynamic entities that display substantial diversity in their assembly, post-translational modifications, and non-covalent…”
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Impact of Phosphorylation on the Mass Spectrometry Quantification of Intact Phosphoproteins by Wu, Zhijie, Tiambeng, Timothy N, Cai, Wenxuan, Chen, Bifan, Lin, Ziqing, Gregorich, Zachery R, Ge, Ying

“…Protein phosphorylation is a ubiquitous and critical post-translational modification (PTM) involved in numerous cellular processes. Mass spectrometry…”
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Structure-Based Design of Dendritic Peptide Bolaamphiphiles for siRNA Delivery by Zeng, Hanxiang, Johnson, Mark E, Oldenhuis, Nathan J, Tiambeng, Timothy N, Guan, Zhibin

“…Development of safe and effective delivery vectors is a critical challenge for the application of RNA interference (RNAi)-based biotechnologies. In this study…”
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Multifunctional Dendronized Peptide Polymer Platform for Safe and Effective siRNA Delivery by Zeng, Hanxiang, Little, Hannah C, Tiambeng, Timothy N, Williams, Gregory A, Guan, Zhibin

“…In this study, we designed and synthesized a biodegradable dendronized polypeptide (denpol) platform for delivery of small interfering RNA (siRNA). The novel…”
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Size Exclusion Chromatography Strategies and MASH Explorer for Large Proteoform Characterization by Tiambeng, Timothy N, Wu, Zhijie, Melby, Jake A, Ge, Ying

“…Top-down mass spectrometry (MS)-based analysis of larger proteoforms (>50 kDa) is typically challenging due to an exponential decay in the signal-to-noise…”
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Characterization of adeno-associated virus capsid proteins using denaturing size-exclusion chromatography coupled with mass spectrometry by Tiambeng, Timothy N., Yan, Yuetian, Patel, Shailin K., Cotham, Victoria C., Wang, Shunhai, Li, Ning

“…Recombinant adeno-associated viruses (AAVs) are a highly effective platform for gene delivery for the treatment of many human diseases. Characterization of AAV…”
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Characterization of an Autoinducing Peptide Signal Reveals Highly Efficacious Synthetic Inhibitors and Activators of Quorum Sensing and Biofilm Formation in Listeria monocytogenes by West, Korbin H. J., Ma, Stella V., Pensinger, Daniel A., Tucholski, Trisha, Tiambeng, Timothy N., Eisenbraun, Emma L., Yehuda, Avishag, Hayouka, Zvi, Ge, Ying, Sauer, John-Demian, Blackwell, Helen E.

“…Bacteria can use chemical signals to assess their local population density in a process called quorum sensing (QS). Many of these bacteria are common…”
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Reproducible large-scale synthesis of surface silanized nanoparticles as an enabling nanoproteomics platform: Enrichment of the human heart phosphoproteome by Roberts, David S., Chen, Bifan, Tiambeng, Timothy N., Wu, Zhijie, Ge, Ying, Jin, Song

“…A reproducible synthetic strategy was developed for facile large-scale (200 mg) synthesis of surface silanized magnetite (Fe 3 O 4 ) nanoparticles (NPs) for…”
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Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research by Zhu, Yanlong, Wancewicz, Benjamin, Schaid, Michael, Tiambeng, Timothy N, Wenger, Kent, Jin, Yutong, Heyman, Heino, Thompson, Christopher J, Barsch, Aiko, Cox, Elizabeth D, Davis, Dawn B, Brasier, Allan R, Kimple, Michelle E, Ge, Ying

“…Metabolomicsthe endpoint of the omics cascadeis increasingly recognized as a preferred method for understanding the ultimate responses of biological systems…”
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Comprehensive Characterization of the Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry by Wu, Zhijie, Jin, Yutong, Chen, Bifan, Gugger, Morgan K., Wilkinson-Johnson, Chance L., Tiambeng, Timothy N., Jin, Song, Ge, Ying

“…Reversible phosphorylation plays critical roles in cell growth, division, and signal transduction. Kinases which catalyze the transfer of γ-phosphate groups of…”
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What Is the Impact of Phosphorylation on the Mass Spectrometry Quantification of Intact Phosphoproteins? by Wu, Zhijie, Tiambeng, Timothy N., Cai, Wenxuan, Chen, Bifan, Lin, Ziqing, Gregorich, Zachery R., Ge, Ying

“…Protein phosphorylation is a ubiquitous and critical post-translational modification (PTM) involved in numerous cellular processes. Mass spectrometry…”
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Comprehensive Characterization of the Recombinant Catalytic Subunit of cAMP-Dependent Protein Kinase by Top-Down Mass Spectrometry by Wu, Zhijie, Jin, Yutong, Chen, Bifan, Gugger, Morgan K, Wilkinson-Johnson, Chance L, Tiambeng, Timothy N, Jin, Song, Ge, Ying

“…Reversible phosphorylation plays critical roles in cell growth, division, and signal transduction. Kinases which catalyze the transfer of γ-phosphate groups of…”
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