In Vivo Antidepressant Effect of Passiflora edulis f. flavicarpa into Cationic Nanoparticles: Improving Bioactivity and Safety

A variety of neuroactive flavonoids can be found in the species of the genus; however, their difficulty in crossing the blood-brain barrier limits their in vivo neuropharmacological activity. In this study, cationic nanoparticles were developed as a novel nanocarrier for improving the antidepressant...

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Published in:	Pharmaceutics Vol. 12; no. 4; p. 383
Main Authors:	Alves, Jovelina Samara Ferreira, Silva, Alaine Maria Dos Santos, da Silva, Rodrigo Moreira, Tiago, Pamella Rebeca Fernandes, de Carvalho, Thais Gomes, de Araújo Júnior, Raimundo Fernandes, de Azevedo, Eduardo Pereira, Lopes, Norberto Peporine, Ferreira, Leandro De Santis, Gavioli, Elaine Cristina, da Silva-Júnior, Arnóbio Antônio, Zucolotto, Silvana Maria
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 21-04-2020 MDPI
Subjects:	Antidepressants Biocompatibility Chromatography depression Drugs Eudragit Flavonoids Nanoparticles nanotechnology oral toxicity PMMA Polyvinyl alcohol Solvents Rio Grande do Norte Brazil Brazil Mexico United States > US Japan Germany nanotechnology depression PMMA flavonoids Eudragit oral toxicity
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Summary:	A variety of neuroactive flavonoids can be found in the species of the genus; however, their difficulty in crossing the blood-brain barrier limits their in vivo neuropharmacological activity. In this study, cationic nanoparticles were developed as a novel nanocarrier for improving the antidepressant activity of f. leaf extract. Formulations obtained using Eudragit E PO polymethylmethacrylate copolymer, as polymeric matrix had their physicochemical properties investigated. The analytical content of the flavonoids vicenin-2, orientin, isoorientin, vitexin, and isovitexin was determined in the plant extract. Small-sized and spherical nanoparticles loaded with f. were obtained with positive zeta potential and high encapsulation efficiency. In addition, the nanosystems were shown to be stable for at least 6 months. The antidepressant activity of extract (50 and 100 mg/kg) as well as the extract-loaded nanoparticles (5 mg/kg) were investigated in mice using the forced swimming test, where the latter increased the potency of the former by 10-fold. In addition, histopathological and biochemical analysis confirmed the biocompatibility of the extract-loaded nanoparticles. This study demonstrated that the Eudragit cationic nanoparticles were able to improve the antidepressant activity of in the central nervous system of mice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1999-4923 1999-4923
DOI:	10.3390/pharmaceutics12040383