First investigation of the prevalence of parvoviruses in slaughterhouse pigs and genomic characterization of ungulate copiparvovirus 2 in Vietnam

Ungulate protoparvovirus 1, also known as porcine parvovirus 1 (PPV1), is considered to be one of the major causes of reproductive failure in pig breeding herds. Other parvoviruses have also been identified in pigs, including ungulate tetraparvovirus 3, or PPV2, ungulate tetraparvovirus 2, or PPV3,...

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Published in:	Archives of virology Vol. 166; no. 3; pp. 779 - 788
Main Authors:	Thuy, Nguyen Thi Dieu, Trung, Nguyen Tran, Dung, Tran Quoc, Khoa, Do Vo Anh, Thuy, Dinh Thi Ngoc, Opriessnig, Tanja
Format:	Journal Article
Language:	English
Published:	Vienna Springer Vienna 01-03-2021 Springer Nature B.V
Subjects:	Abattoirs Amino acid sequence Amino Acid Sequence - genetics Animals Biomedical and Life Sciences Biomedicine DNA, Viral - genetics Genome - genetics Genome, Viral - genetics Genomes Hogs Infectious Diseases Medical Microbiology Nucleotide sequence Open reading frames Original Article Parvoviridae Infections - epidemiology Parvoviridae Infections - pathology Parvovirinae - classification Parvovirinae - genetics Parvovirinae - isolation & purification Parvoviruses Phylogeny Reproductive failure Sequence Analysis, DNA Sus scrofa - virology Swine Swine Diseases - epidemiology Swine Diseases - virology Vietnam - epidemiology Virology Vietnam
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Summary:	Ungulate protoparvovirus 1, also known as porcine parvovirus 1 (PPV1), is considered to be one of the major causes of reproductive failure in pig breeding herds. Other parvoviruses have also been identified in pigs, including ungulate tetraparvovirus 3, or PPV2, ungulate tetraparvovirus 2, or PPV3, and ungulate copiparvovirus 2, or PPV4, but their significance for pigs is unknown. In the present study, the prevalence of PPV1-4 was investigated using a total of 231 lung and serum samples collected from slaughterhouses in 13 provinces throughout Vietnam. The overall prevalence was 54.5% (126/231) for PPV1, 28.0% (65/231) for PPV2, 17.7% (41/231) for PPV3, and 7.8% (18/231) for PPV4. While PPV1 and PPV2 were found in 11 provinces, PPV4 was detected in only three provinces. Co-circulation of PPV1, PPV2 and PPV3 was frequently observed, with PPV1/PPV2 coinfection predominating, with 20.8% (48/231). All four PPVs were detected together in only one sample from Thua Thien Hue. Three nearly complete PPV4 genome sequences of 5,453 nt were determined and deposited in the GenBank database. Alignment and comparison of the three genome sequences showed 99.5-99.6% nucleotide sequence identity, and the deduced amino acid sequences of open reading frames 1-3 were 99.6-99.9% identical to each other, 98.9-99.3% identical to those of other Vietnamese strains and 99.4-99.7% identical to those of Chinese strains). Phylogenetic analysis further confirmed a close relationship between Vietnamese and Chinese PPV4 strains. These results are the first to report the prevalence of PPV1, PPV2, PPV3, and PPV4 and nearly complete genomic sequences of PPV4 in pigs from slaughterhouses in Vietnam.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-8608 1432-8798
DOI:	10.1007/s00705-020-04928-5