Search Results - "Thurman, Andrea R."
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Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis
Published in Nature communications (01-12-2020)“…Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus -dominant vaginal microbiota…”
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Cryopreservation Does Not Affect the Clinical Pregnancy Rate of Blastocysts Derived from Vitrified Oocytes
Published in Scientific reports (27-05-2022)“…Vitrified, or “frozen”, donor eggs can either be fertilized and cultured for fresh transfer (group 1), or fertilized and cryopreserved for transfer in a…”
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Innate Immunity and Inflammatory Response to Trichomonas vaginalis and Bacterial Vaginosis: Relationship to HIV Acquisition
Published in American journal of reproductive immunology (1989) (01-02-2011)“…Citation Thurman AR, Doncel GF. Innate immunity and inflammatory response to Trichomonas vaginalis and bacterial vaginosis: relationship to HIV acquisition. Am…”
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Randomized, placebo controlled phase I trial of the safety, pharmacokinetics, pharmacodynamics and acceptability of a 90 day tenofovir plus levonorgestrel vaginal ring used continuously or cyclically in women: The CONRAD 138 study
Published in PloS one (10-10-2022)“…Multipurpose prevention technologies (MPTs), which prevent sexually transmitted infection(s) and unintended pregnancy, are highly desirable to women. In this…”
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End-user research in support of long-acting systemic antiretroviral delivery systems: insights from qualitative research with providers and target users in South Africa
Published in BMC infectious diseases (08-12-2022)“…While oral pre-exposure prophylaxis (PrEP) has been shown to reduce the risk of HIV, challenges such as adhering to a daily-dosing regimen and persistence have…”
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Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya
Published in Scientific reports (14-07-2022)“…In a phase-IIa trial, we investigated the influence of 90 days continuous-delivery tenofovir (TFV) intravaginal rings (IVRs) with/without levonorgestrel (LNG)…”
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A phase I study to assess safety, pharmacokinetics, and pharmacodynamics of a vaginal insert containing tenofovir alafenamide and elvitegravir
Published in Frontiers in cellular and infection microbiology (19-04-2023)“…New multi-purpose prevention technology (MPT) products are needed to prevent human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV2). In this…”
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Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using a 90-Day Tenofovir/Levonorgestrel Vaginal Ring
Published in Frontiers in cellular and infection microbiology (08-03-2022)“…A relationship between the vaginal microbiota and tenofovir (TFV) concentrations and activity after topical administration has been previously reported. CONRAD…”
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Rapid measures of user's adherence to vaginal drug products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and multivariate discriminant techniques
Published in PloS one (25-05-2018)“…The topical HIV prevention (microbicides) field is in acute need of a method to rapidly and objectively measure adherence to product use in clinical trials…”
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Role of Semen in HIV-1 Transmission: Inhibitor or facilitator?
Published in American journal of reproductive immunology (1989) (01-03-2011)“…Citation Doncel GF, Joseph T, Thurman AR. Role of semen in HIV‐1 transmission: inhibitor or facilitator? Am J Reprod Immunol 2011; 65: 292–301 Sexual…”
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Topical Inserts: A Versatile Delivery Form for HIV Prevention
Published in Pharmaceutics (01-08-2019)“…The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a…”
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Safety and Pharmacokinetics of a Tenofovir Alafenamide Fumarate-Emtricitabine based Oral Antiretroviral Regimen for Prevention of HIV Acquisition in Women: A Randomized Controlled Trial
Published in EClinicalMedicine (01-06-2021)“…Daily oral emtricitabine (FTC, F)/tenofovir disoproxil fumarate (TDF) combination is approved for HIV pre-exposure prophylaxis (PrEP) in men and women…”
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Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women
Published in Nutrients (17-10-2020)“…While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune…”
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Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya
Published in Frontiers in reproductive health (13-06-2023)“…Globally, many young women face the overlapping burden of HIV infection and unintended pregnancy. Protection against both may benefit from safe and effective…”
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Application of a composite measure of product adherence, protocol compliance, and semen exposure to a phase III microbicide HIV prevention trial
Published in Translational medicine communications (14-09-2021)“…Abstract Background Strict adherence to antiretroviral-based microbicide use is important for effective HIV prevention. We previously developed a composite…”
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The use of objective adherence measures targeting four placebo microbicide delivery forms in the Quatro Clinical Crossover Study
Published in Clinical and translational discovery (01-10-2021)“…Background Adherence to topical microbicides for HIV prevention has been a challenge for women using them and those developing novel products. The Quatro…”
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Development and clinical assessment of new objective adherence markers for four microbicide delivery systems used in HIV prevention studies
Published in Clinical and translational medicine (07-11-2018)“…Background Adherence is critical for successful topical, vaginally delivered anti-retroviral (ARV)-based HIV pre-exposure prophylaxis (PrEP). Quantitating…”
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Recurrent bacterial vaginosis following metronidazole treatment is associated with microbiota richness at diagnosis
Published in American journal of obstetrics and gynecology (01-02-2022)“…Bacterial vaginosis—a condition defined by a shift from Lactobacillus dominance to a polymicrobial, anaerobic bacterial community—increases the risk of…”
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Antibody-dependent complement-mediated sperm cytotoxicity in the endocervix is a dominant contraceptive mechanism of ZB-06 vaginal film
Published in Fertility and sterility (22-10-2024)Get full text
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Safety of topical sildenafil cream, 3.6% in a randomized, placebo-controlled trial for the treatment of female sexual arousal disorder
Published in Journal of sexual medicine (03-09-2024)“…There are currently no Food and Drug Administration-approved treatments for female sexual arousal disorder (FSAD), which is physiologically analogous to male…”
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