Search Results - "Thurber, Greg"

Use of mathematical modeling to guide out-of-the-box thinking for ADC development by Thurber, Greg

Get full text

Key metrics to expanding the pipeline of successful antibody–drug conjugates by Nessler, Ian, Menezes, Bruna, Thurber, Greg M.

“…Although the recent FDA approval of six new antibody–drug conjugates (ADCs) is promising, attrition of ADCs during clinical development remains high. The…”
Get full text

Reply: From Mice to Humans: The Exocrine Pancreas Does Not Matter in Human GLP-1 Receptor Imaging by Thurber, Greg M

Get full text

Pharmacokinetic and Immunological Considerations for Expanding the Therapeutic Window of Next-Generation Antibody–Drug Conjugates by Khera, Eshita, Thurber, Greg M.

“…Antibody–drug conjugate (ADC) development has evolved greatly over the last 3 decades, including the Food and Drug Administration (FDA) approval of several new…”
Get full text

Hitting Undruggable Targets: Viewing Stabilized Peptide Development through the Lens of Quantitative Systems Pharmacology by Atangcho, Lydia, Navaratna, Tejas, Thurber, Greg M.

“…Stabilized peptide therapeutics have the potential to hit currently undruggable targets, dramatically expanding the druggable genome. However, major obstacles…”
Get full text

Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates by Kopp, Anna, Thurber, Greg M

“…As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release…”
Get more information

Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance by Cilliers, Cornelius, Nessler, Ian, Christodolu, Nikolas, Thurber, Greg M

“…Monoclonal antibodies labeled with near-infrared (NIR) fluorophores have potential use in disease detection, intraoperative imaging, and pharmacokinetic…”
Get full text

Improved Tumor Penetration and Single-Cell Targeting of Antibody-Drug Conjugates Increases Anticancer Efficacy and Host Survival by Cilliers, Cornelius, Menezes, Bruna, Nessler, Ian, Linderman, Jennifer, Thurber, Greg M

“…Current antibody-drug conjugates (ADC) have made advances in engineering the antibody, linker, conjugation site, small-molecule payload, and drug-to-antibody…”
Get full text

Design of high avidity and low affinity antibodies for in situ control of antibody drug conjugate targeting by Evans, Reginald, Thurber, Greg M.

“…Antibody-Drug Conjugates (ADCs) have rapidly expanded in the clinic, with 7 new approvals in 3 years. For solid tumors, high doses of ADCs improve tissue…”
Get full text

Increased Tumor Penetration of Single-Domain Antibody-Drug Conjugates Improves In Vivo Efficacy in Prostate Cancer Models by Nessler, Ian, Khera, Eshita, Vance, Steven, Kopp, Anna, Qiu, Qifeng, Keating, Thomas A, Abu-Yousif, Adnan O, Sandal, Thomas, Legg, James, Thompson, Lorraine, Goodwin, Normann, Thurber, Greg M

“…Targeted delivery of chemotherapeutics aims to increase efficacy and lower toxicity by concentrating drugs at the site-of-action, a method embodied by the…”
Get full text

A systems approach for tumor pharmacokinetics by Thurber, Greg Michael, Weissleder, Ralph

“…Recent advances in genome inspired target discovery, small molecule screens, development of biological and nanotechnology have led to the introduction of a…”
Get full text

Mechanistically Weighted Metric to Predict In Vivo Antibody-Receptor Occupancy: An Analytical Approach by Khera, Eshita, Kim, Jaeyeon, Stein, Andrew, Ratanapanichkich, Matt, Thurber, Greg M

“…In situ clinical measurement of receptor occupancy (RO) is challenging, particularly for solid tumors, necessitating the use of mathematical models that…”
Get full text

Multiscale Modeling of Antibody-Drug Conjugates: Connecting Tissue and Cellular Distribution to Whole Animal Pharmacokinetics and Potential Implications for Efficacy by Cilliers, Cornelius, Guo, Hans, Liao, Jianshan, Christodolu, Nikolas, Thurber, Greg M.

“…Antibody-drug conjugates exhibit complex pharmacokinetics due to their combination of macromolecular and small molecule properties. These issues range from…”
Get full text

Antibody-Drug Conjugate Sacituzumab Govitecan Drives Efficient Tissue Penetration and Rapid Intracellular Drug Release by Kopp, Anna, Hofsess, Scott, Cardillo, Thomas M, Govindan, Serengulam V, Donnell, Jennifer, Thurber, Greg M

“…Antibody-drug conjugates (ADC) are a rapidly growing class of targeted cancer treatments, but the field has experienced significant challenges from their…”
Get full text

Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2-Positive Tumors by Menezes, Bruna, Linderman, Jennifer J, Thurber, Greg M

“…Intratumoral heterogeneity is a leading cause of treatment failure resulting in tumor recurrence. For the antibody-drug conjugate (ADC) ado-trastuzumab…”
Get full text

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance by Thurber, Greg M., Schmidt, Michael M., Wittrup, K. Dane

“…Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous…”
Get full text

Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates by Lu, Guolan, Nishio, Naoki, van den Berg, Nynke S., Martin, Brock A., Fakurnejad, Shayan, van Keulen, Stan, Colevas, Alexander D., Thurber, Greg M., Rosenthal, Eben L.

“…Poor tissue penetration remains a major challenge for antibody-based therapeutics of solid tumors, but proper dosing can improve the tissue penetration and…”
Get full text

Optimizing Solid Tumor Treatment with Antibody–drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class by Calopiz, Melissa C., Linderman, Jennifer J., Thurber, Greg M.

“…Introduction Antibody–drug conjugates (ADCs) show significant clinical efficacy in the treatment of solid tumors, but a major limitation to their success is…”
Get full text

Cellular-Resolution Imaging of Bystander Payload Tissue Penetration from Antibody-Drug Conjugates by Khera, Eshita, Dong, Shujun, Huang, Haolong, de Bever, Laureen, van Delft, Floris L, Thurber, Greg M

“…After several notable clinical failures in early generations, antibody-drug conjugates (ADC) have made significant gains with seven new FDA approvals within…”
Get full text

Reactive polymer enables efficient in vivo bioorthogonal chemistry by Devaraj, Neal K, Thurber, Greg M, Keliher, Edmund J, Marinelli, Brett, Weissleder, Ralph

“…There has been intense interest in the development of selective bioorthogonal reactions or "click" chemistry that can proceed in live animals. Until now…”
Get full text