Search Results - "Thummel, KE"

EVIDENCE OF SIGNIFICANT CONTRIBUTION FROM CYP3A5 TO HEPATIC DRUG METABOLISM by WEILI HUANG, LIN, Yvonne S, MCCONN, Donavon J, CALAMIA, Justina C, TOTAH, Rheem A, ISOHERRANEN, Nina, GLODOWSKI, Mary, THUMMEL, Kenneth E

“…CYP3A4 and CYP3A5 exhibit significant overlap in substrate specificity but can differ in product regioselectivity and formation activity. To further explore…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing by Birdwell, KA, Decker, B, Barbarino, JM, Peterson, JF, Stein, CM, Sadee, W, Wang, D, Vinks, AA, He, Y, Swen, JJ, Leeder, JS, van Schaik, RHN, Thummel, KE, Klein, TE, Caudle, KE, MacPhee, IAM

“…Tacrolimus is the mainstay immunosuppressant drug used after solid organ and hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive…”
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Enzyme-catalyzed processes of first-pass hepatic and intestinal drug extraction by Thummel, Kenneth E., Kunze, Kent L., Shen, Danny D.

“…Oral bioavailability of pharmacologically effective drugs is often limited by first-pass biotransformation. In humans, both hepatic and intestinal enzymes can…”
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Fentanyl Metabolism by Human Hepatic and Intestinal Cytochrome P450 3A4: Implications for Interindividual Variability in Disposition, Efficacy, and Drug Interactions by LABROO, R. B, PAINE, M. F, THUMMEL, K. E, KHARASCH, E. D

“…The synthetic opioid fentanyl undergoes extensive metabolism in humans. Systemic elimination occurs primarily by hepatic metabolism. When administered as a…”
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Effects of Pregnancy on CYP3A and P-glycoprotein Activities as Measured by Disposition of Midazolam and Digoxin: A University of Washington Specialized Center of Research Study by Hebert, MF, Easterling, TR, Kirby, B, Carr, DB, Buchanan, ML, Rutherford, T, Thummel, KE, Fishbein, DP, Unadkat, JD

“…The objectives of the study were to evaluate the effects of pregnancy on CYP3A and P‐glycoprotein (P‐gp) activities, as measured by disposition of midazolam…”
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Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults by Thummel, Kenneth E., Slattery, John T., Ro, Howard, Chien, Jenny Y., Nelson, Sidney D., Lown, Kenneth E., Watkins, Paul B.

“…Background Recent case reports suggest that consumption of ethanol may increase the risk of liver injury induced by acetaminophen (INN, paracetamol). However,…”
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Assessment of the Impact of Renal Impairment on Systemic Exposure of New Molecular Entities: Evaluation of Recent New Drug Applications by Zhang, Y, Zhang, L, Abraham, S, Apparaju, S, Wu, T‐C, Strong, JM, Xiao, S, Atkinson, AJ, Thummel, KE, Leeder, JS, Lee, C, Burckart, GJ, Lesko, LJ, Huang, S‐M

“…The US Food and Drug Administration (FDA) is currently developing a guidance for industry to replace a previous guidance, “Pharmacokinetics in Patients With…”
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Comparison of CYP2D6 content and metoprolol oxidation between microsomes isolated from human livers and small intestines by MADANI, S, PAINE, M. F, LEWIS, L, THUMMEL, K. E, SHEN, D. D

“…To assess the role of intestinal CYP2D6 in oral first-pass drug clearance by comparing the enzyme content and catalytic activity of a prototype CYP2D6…”
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Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1 by Thummel, K E, Kharasch, E D, Podoll, T, Kunze, K

“…The volatile anesthetic agent enflurane undergoes oxidative metabolism in human liver, yielding both inorganic and organic fluoride metabolites. Numerous…”
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Effect of VKORC1 Haplotypes on Transcriptional Regulation and Warfarin Dose by Rieder, Mark J, Reiner, Alexander P, Gage, Brian F, Nickerson, Deborah A, Eby, Charles S, McLeod, Howard L, Blough, David K, Thummel, Kenneth E, Veenstra, David L, Rettie, Allan E

“…The gene encoding vitamin K epoxide reductase complex 1 ( VKORC1 ) is the target of warfarin, and a variant of the gene may be associated with variations in…”
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Genetic contribution to variable human CYP3A-mediated metabolism by Lamba, Jatinder K, Lin, Yvonne S, Schuetz, Erin G, Thummel, Kenneth E

“…The human CYP3A subfamily plays a dominant role in the metabolic elimination of more drugs than any other biotransformation enzyme. CYP3A enzyme is localized…”
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Human UGT1A4 and UGT1A3 Conjugate 25-Hydroxyvitamin D3: Metabolite Structure, Kinetics, Inducibility, and Interindividual Variability by Wang, Zhican, Wong, Timothy, Hashizume, Takanori, Dickmann, Leslie Z, Scian, Michele, Koszewski, Nicholas J, Goff, Jesse P, Horst, Ronald L, Chaudhry, Amarjit S, Schuetz, Erin G, Thummel, Kenneth E

“…25-Hydroxyvitamin D3 (25OHD3) is used as a clinical biomarker for assessment of vitamin D status. Blood levels of 25OHD3 represent a balance between its…”
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Evaluation of 6β‐Hydroxycortisol, 6β‐Hydroxycortisone, and a Combination of the Two as Endogenous Probes for Inhibition of CYP3A4 In Vivo by Peng, C‐C, Templeton, I, Thummel, KE, Davis, C, Kunze, KL, Isoherranen, N

“…An endogenous probe for CYP3A activity would be useful for early identification of in vivo cytochrome P450 (CYP) 3A4 inhibitors. The aim of this study was to…”
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EFFECT OF CYP3A5 POLYMORPHISM ON TACROLIMUS METABOLIC CLEARANCE IN VITRO by YANG DAI, HEBERT, Mary F, ISOHERRANEN, Nina, DAVIS, Connie L, MARSH, Christopher, SHEN, Danny D, THUMMEL, Kenneth E

“…Previous investigations of solid organ transplant patients treated with tacrolimus showed that individuals carrying a CYP3A5*1 allele have lower dose-adjusted…”
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Genetic Risk Factors for Major Bleeding in Patients Treated With Warfarin in a Community Setting by Roth, J A, Boudreau, D, Fujii, M M, Farin, F M, Rettie, A E, Thummel, K E, Veenstra, D L

“…The influence of warfarin pharmacogenomics on major bleeding risk has been little studied in long‐term users and non–specialist care settings. We conducted a…”
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In vitro and in vivo drug interactions involving human CYP3A by Thummel, K E, Wilkinson, G R

“…Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans. Moreover, its localization in high…”
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ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION by ISOHERRANEN, Nina, KUNZE, Kent L, ALLEN, Kyle E, NELSON, Wendel L, THUMMEL, Kenneth E

“…Itraconazole (ITZ) is a potent inhibitor of CYP3A in vivo. However, unbound plasma concentrations of ITZ are much lower than its reported in vitro K i , and no…”
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Accurate Prediction of Dose‐Dependent CYP3A4 Inhibition by Itraconazole and Its Metabolites From In Vitro Inhibition Data by Templeton, I, Peng, C‐C, Thummel, K E, Davis, C, Kunze, K L, Isoherranen, N

“…Inhibitory drug metabolites may contribute to drug–drug interactions (DDIs). The aim of this study was to determine the importance of inhibitory metabolites of…”
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Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism by Lin, Yvonne S, Dowling, Amy L S, Quigley, Sean D, Farin, Federico M, Zhang, Jiong, Lamba, Jatinder, Schuetz, Erin G, Thummel, Kenneth E

“…We recently demonstrated that a variant allele of CYP3A5 (CYP3A5*3) confers low CYP3A5 expression as a result of improper mRNA splicing. In this study, we…”
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Ethical Issues in Developing Pharmacogenetic Research Partnerships With American Indigenous Communities by Boyer, BB, Dillard, D, Woodahl, EL, Whitener, R, Thummel, KE, Burke, W

“…Pharmacogenetic research offers the potential to improve the safety and efficacy of drug prescribing. Assuring that the benefits of this research reach…”
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