Search Results - "Thumar, Jaykumar"

FOLFIRINOX for locally advanced and metastatic pancreatic cancer: single institution retrospective review of efficacy and toxicity by Gunturu, Krishna S., Yao, Xiaopan, Cong, Xiangyu, Thumar, Jaykumar R., Hochster, Howard S., Stein, Stacey M., Lacy, Jill

“…Although FOLFIRINOX significantly increases survival in metastatic pancreatic cancer (MPC) compared to gemcitabine (Conroy et al. N Engl J Med 364:1817–1825,…”
Get full text

Antiphospholipid Syndrome Presenting With Splenic Infarct by Hadfield, Matthew J., Thumar, Jaykumar R.

Get full text

Ipilimumab: a promising immunotherapy for melanoma by Thumar, Jaykumar R, Kluger, Harriet M

“…Antibody-based targeting of the immune suppressor molecule cytotoxic T-lymphocyte antigen 4 (CTLA-4) with ipilimumab has been studied in metastatic melanoma in…”
Get more information

Vandetanib (ZD6474) in the Treatment of Medullary Thyroid Cancer by Deshpande, Hari, Roman, Sanziana, Thumar, Jaykumar, Sosa, Julie Ann

“…Vandetanib (ZD6474) is an orally bioavailable small molecule tyrosine kinase inhibitor of multiple growth factor receptors, including RET (Rearrange during…”
Get full text

Phase IB/II Randomized Study of FOLFIRINOX Plus Pegylated Recombinant Human Hyaluronidase Versus FOLFIRINOX Alone in Patients With Metastatic Pancreatic Adenocarcinoma: SWOG S1313 by Ramanathan, Ramesh K, McDonough, Shannon L, Philip, Philip A, Hingorani, Sunil R, Lacy, Jill, Kortmansky, Jeremy S, Thumar, Jaykumar, Chiorean, E Gabriela, Shields, Anthony F, Behl, Deepti, Mehan, Paul T, Gaur, Rakesh, Seery, Tara, Guthrie, Katherine A, Hochster, Howard S

“…Pegylated recombinant human hyaluronidase (PEGPH20) degrades hyaluronan (HA) and, in combination with chemotherapy, prolongs survival in preclinical models…”
Get full text

Proteomics Analysis of Human Coronary Atherosclerotic Plaque by Bagnato, Carolina, Thumar, Jaykumar, Mayya, Viveka, Hwang, Sun-Il, Zebroski, Henry, Claffey, Kevin P., Haudenschild, Christian, Eng, Jimmy K., Lundgren, Deborah H., Han, David K.

“…Cardiovascular disease presents significant variations in human populations with respect to the atherosclerotic plaque progression, inflammation, thrombosis,…”
Get full text

Identification of Putative Androgen Receptor Interaction Protein Modules by Jasavala, Rohini, Martinez, Harryl, Thumar, Jaykumar, Andaya, Armann, Gingras, Anne-Claude, Eng, Jimmy K., Aebersold, Ruedi, Han, David K., Wright, Michael E.

“…We have developed a novel androgen receptor (AR) expression system in the 293 human embryonic kidney cell line that recapitulates AR biochemical activity as a…”
Get full text

SWOG 1815: A phase III randomized trial of gemcitabine, cisplatin, and nab-paclitaxel versus gemcitabine and cisplatin in newly diagnosed, advanced biliary tract cancers by Shroff, Rachna T., Guthrie, Katherine A, Scott, Aaron James, Borad, Mitesh J., Goff, Laura Williams, Matin, Khalid, Mahipal, Amit, Kalyan, Aparna, Javle, Milind M., Aghajanian, Carol, Tan, Benjamin R., Cheema, Puneet S., Patel, Anuj K., Iyer, Renuka V., Kelley, Robin Kate, Thumar, Jaykumar Ranchodbhai, El-Khoueiry, Anthony B., Chiorean, E. Gabriela, Hochster, Howard S., Philip, Philip Agop

“…LBA490 Background: Biliary tract cancers (BTCs) are a heterogeneous group of malignancies with a dismal prognosis. Gemcitabine-based regimens are the standard…”
Get full text

A phase 1b expansion study of TAS‐102 with oxaliplatin for refractory metastatic colorectal cancer by Cecchini, Michael, Kortmansky, Jeremy S., Cui, Can, Wei, Wei, Thumar, Jaykumar Ranchobdhai, Uboha, Nataliya V., Hafez, Navid, Lacy, Jill, Fischbach, Neal A., Sabbath, Kert D., Gomez, Christina M., Sporn, Jonathan Reed, Stein, Stacey, Hochster, Howard S.

“…Background TAS‐102, a novel antimetabolite, is approved for treatment of refractory metastatic colorectal cancer (CRC). This study sought to determine whether…”
Get full text

MEK targeting in N-RAS mutated metastatic melanoma by Thumar, Jaykumar, Shahbazian, David, Aziz, Saadia A, Jilaveanu, Lucia B, Kluger, Harriet M

“…Gain of function mutations in B-RAF and N-RAS occur frequently in melanoma, leading to mitogen activating protein kinase (MAPK) pathway activation, and this…”
Get full text

A phase I study of TAS-102 in combination with oxaliplatin (TAS-OX) for refractory metastatic colorectal cancer (mCRC) by Cecchini, Michael, Kortmansky, Jeremy S., Lacy, Jill, Fischbach, Neal A., Thumar, Jaykumar Ranchodbhai, Sabbath, Kert D., Gomez, Christina M., Sporn, Jonathan, Stein, Stacey, Hochster, Howard S.

“…Abstract only 630 Background: TAS-102 is an oral combination of the anti-metabolite 5-trifluorothymidine (FTD) and a thymidine phosphorylase inhibitor (TPI),…”
Get full text

Proteomics analysis of human coronary atherosclerotic plaque: a feasibility study of direct tissue proteomics by liquid chromatography and tandem mass spectrometry by Bagnato, Carolina, Thumar, Jaykumar, Mayya, Viveka, Hwang, Sun-Il, Zebroski, Henry, Claffey, Kevin P, Haudenschild, Christian, Eng, Jimmy K, Lundgren, Deborah H, Han, David K

“…Cardiovascular disease presents significant variations in human populations with respect to the atherosclerotic plaque progression, inflammation, thrombosis,…”
Get full text

A phase IB/II randomized study of mFOLFIRINOX (mFFOX) + pegylated recombinant human hyaluronidase (PEGPH20) versus mFFOX alone in patients with good performance status metastatic pancreatic adenocarcinoma (mPC): SWOG S1313 (NCT #01959139) by Ramanathan, Ramesh K., McDonough, Shannon, Philip, Philip Agop, Hingorani, Sunil R., Lacy, Jill, Kortmansky, Jeremy S., Thumar, Jaykumar Ranchodbhai, Chiorean, E. Gabriela, Shields, Anthony Frank, Behl, Deepti, Mehan, Paul Tracy, Gaur, Rakesh, Seery, Tara Elisabeth, Guthrie, Katherine, Hochster, Howard S.

“…Abstract only 208 Background: PEGPH20 degrades hyaluronan (HA), a major component of the stroma, increases delivery of gemcitabine and prolongs survival in…”
Get full text

Abstract A002: A phase II study of peri-operative modified FOLFIRINOX in localized pancreatic ductal adenocarcinoma (PDAC) by Cecchini, Michael, Salem, Ronald, Robert, Marie, Czerniak, Suzanne, Rajaei, Moein, Townsend, Jeffrey, Blaha, Ondrej, Zelterman, Daniel, Thumar, Jaykumar, Kortmansky, Jeremy, Zaheer, Wajih, Fischbach, Neal, Persico, Justin, Stein, Stacey, Khan, Sajid, Cha, Charles, Billingsley, Kevin, Kunstman, John, Chowdhury, Sumedha, Tseng, Robert, Mauricio, Carlos, Yugawa, Deanne, Escobar-Hoyos, Luisa, Johung, Kimberly, Wiess, Christina, Spickard, Erik, Aushev, Vasily N., Laliotis, George, Jurdi, Adham, Liu, Minetta C., Lacy, Jill

“…Abstract Introduction: Advances in adjuvant chemotherapy with 5-fluorouracil, irinotecan, and oxaliplatin (FFX) have improved survival for patients (pts) with…”
Get full text

Abstract CT170: A phase 1/2 study of olaparib in combination with ramucirumab in metastatic gastric and gastroesophageal junction adenocarcinoma (GEJ) by Cecchini, Michael, Chao, Joseph, Shyr, Yu, Cleary, James, Uboha, Nataliya, Cho, May, Shields, Anthony, Pant, Shubham, Goff, Laura, Spencer, Kristin, Kim, Edward, Hsu, Chih-Yuan, Stein, Stacey, Thumar, Jaykumar, Kortmansky, Jeremy, Kunstman, John, LoRusso, Patricia, Ivy, Percy, Lacy, Jill

“…Abstract Background: Ramucirumab is a monoclonal antibody that binds to the vascular endothelial growth factor receptor 2, increasing hypoxia in the tumor…”
Get full text

Single institution experience with FOLFIRINOX in advanced pancreatic cancer (PC) by Gunturu, Krishna Soujanya, Thumar, Jaykumar Ranchodbhai, Hochster, Howard S., Stein, Stacey, Yao, Xiaopan, Cong, Xiangyu, Lacy, Jill

“…Abstract only e14534 Background: FOLFIRINOX significantly increases survival in metastatic PC compared to gemcitabine (Conroy. New Engl J Med 2011;364)…”
Get full text

Identification of putative androgen receptor interaction protein modules: cytoskeleton and endosomes modulate androgen receptor signaling in prostate cancer cells by Jasavala, Rohini, Martinez, Harryl, Thumar, Jaykumar, Andaya, Armann, Gingras, Anne-Claude, Eng, Jimmy K, Aebersold, Ruedi, Han, David K, Wright, Michael E

“…We have developed a novel androgen receptor (AR) expression system in the 293 human embryonic kidney cell line that recapitulates AR biochemical activity as a…”
Get full text

Cytomegalovirus Colitis in an Immunocompetent Patient: Review of Endoscopy Findings by Kanth, Priyanka, Thumar, Jaykumar, Respicio, Guada, Rubinstien, Eytan, Anthony, Zaldonis

Get full text

Single-institution experience with FOLFIRINOX in advanced pancreatic cancer (PC) by Gunturu, Krishna Soujanya, Thumar, Jaykumar Ranchodbhai, Hochster, Howard S., Stein, Stacey, Yao, Xiaopan, Cong, Xiangyu, Hahn, Carol, Kaley, Kristin, Lacy, Jill

“…Abstract only 330 Background: FOLFIRINOX provides clinically significant benefit in advanced PC compared to gemcitabine (Conroy et al. New Engl J Med…”
Get full text

Drug targets and predictive biomarkers in the management of metastatic melanoma by Thumar, Jaykumar, Giesen, Eva, Kluger, Harriet M

“…Melanoma is the leading cause of fatal skin cancer, and in the past few decades, there has been an increase in the incidence of and mortality from metastatic…”
Get full text