Search Results - "Thuma, P. E."

Curdlan sulphate in human severe/cerebral Plasmodium falciparum malaria by Havlik, I., Looareesuwan, S., Vannaphan, S., Wilairatana, P., Krudsood, S., Thuma, P.E., Kozbor, D., Watanabe, N., Kaneko, Y.

“…Preclinical studies have shown that curdlan sulphate (CRDS), a sulphated 1 → 3-β-D glucan, inhibits Plasmodium falciparum in vitro and down-modulates the…”
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Distinct Clinical and Immunologic Profiles in Severe Malarial Anemia and Cerebral Malaria in Zambia by Thuma, Philip E., van Dijk, Janneke, Bucala, Rick, Debebe, Zufan, Nekhai, Sergei, Kuddo, Thea, Nouraie, Mehdi, Weiss, Günter, Gordeuk, Victor R.

“…Background. The mechanisms of severe malarial anemia and cerebral malaria, which are extreme manifestations of Plasmodium falciparum malaria, are not fully…”
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Cerebrospinal Fluid Levels of Biopterin, Nitric Oxide Metabolites, and Immune Activation Markers and the Clinical Course of Human Cerebral Malaria by Weiss, Günter, Thuma, Philip E., Biemba, Godfrey, Mabeza, George, Werner, Ernst R., Gordeuk, Victor R.

“…Cerebrospinal fluid samples from 130 children who presented with cerebral malaria were investigated to elucidate the impact of biopterin production, NO…”
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Modulatory Potential of Iron Chelation Therapy on Nitric Oxide Formation in Cerebral Malaria by Weiss, Günter, Thuma, Philip E., Mabeza, George, Werner, Ernst R., Herold, Manfred, Gordeuk, Victor R.

“…To determine whether iron chelation modulates nitric oxide (NO) formation and cell-mediated immune effector function in children with cerebral malaria, serum…”
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Severe anaemia in Zambian children with Plasmodium falciparum malaria by Biemba, Godfrey, Dolmans, Dennis, Thuma, Philip E., Weiss, Günter, Gordeuk, Victor R.

“…Summary Background   Severe anaemia and cerebral malaria are highly prevalent complications of Plasmodium falciparum malaria among African children. The…”
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Congenital malaria in a hyperendemic area by Larkin, G L, Thuma, P E

“…The prevalence of Plasmodium falciparum malaria was evaluated in all near-term pregnant women and their newborns at the Macha Hospital in the Southern Province…”
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Effect of iron chelation therapy on mortality in Zambian children with cerebral malaria by Thuma, Philip E., Mabeza, George F., Biemba, Godfrey, Bhat, G.J., McLaren, Christine E., Moyo, Victor M., Zulu, Stenford, Khumalo, Hlosukwazi, Mabeza, Patricia, M'Hango, Abraham, Parry, Dean, Poltera, Anton A., Brittenham, Gary M., Gordeuk, Victor R.

“…To examine the effect of iron chelation on mortality in cerebral malaria, we enrolled 352 children in a trial of deferoxamine in addition to standard quinine…”
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Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia by GORDEUK, V. R, THUMA, P. E, BRITTENHAM, G. M, ZULU, S, SIMWANZA, G, MHANGU, A, FLESCH, G, PARRY, D

“…To determine if iron chelation therapy has activity against human malaria, we administered desferrioxamine B in amounts of 100 mg/kg per day by continuous…”
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Transferrin Saturation and Recovery From Coma in Cerebral Malaria by Gordeuk, Victor R., Thuma, Philip E., McLaren, Christine E., Biemba, Godfrey, Zulu, Stenford, Poltera, Anton A., Askin, Jim E., Brittenham, Gary M.

“…To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we…”
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A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria by Thuma, P E, Bhat, G J, Mabeza, G F, Osborne, C, Biemba, G, Shakankale, G M, Peeters, P A, Oosterhuis, B, Lugt, C B, Gordeuk, V R

“…The efficacy and safety of intramuscular artemotil (ARTECEF) was compared to intravenous quinine in African children with cerebral malaria. This prospective…”
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Prolonged macrophage activation and persistent anaemia in children with complicated malaria by Biemba, G., Gordeuk, V. R., Thuma, P. E., Mabeza, G. F., Weiss, G.

“…objective    To determine if prolonged immune activation may be associated with the persistence of anaemia after treatment for severe malaria, we measured…”
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Serum neopterin, interleukin-4, and interleukin-6 concentrations in cerebral malaria patients and the effect of iron chelation therapy by Thuma, P E, Weiss, G, Herold, M, Gordeuk, V R

“…To determine if iron chelation therapy alters immune responses in children with cerebral malaria, we retrospectively measured mean serum levels of neopterin,…”
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Iron chelation as a chemotherapeutic strategy for falciparum malaria by Gordeuk, V R, Thuma, P E, Brittenham, G M, Biemba, G, Zulu, S, Simwanza, G, Kalense, P, M'Hango, A, Parry, D, Poltera, A A

“…To examine the effect of iron chelation against human malaria, 37 Zambians with asymptomatic Plasmodium falciparum infections were randomly assigned to 72-hr…”
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Assessment of the effect of the oral iron chelator deferiprone on asymptomatic Plasmodium falciparum parasitemia in humans by Thuma, P E, Olivieri, N F, Mabeza, G F, Biemba, G, Parry, D, Zulu, S, Fassos, F F, McClelland, R A, Koren, G, Brittenham, G M, Gordeuk, V R

“…While the parenteral iron-chelating agent desferrioxamine B has anti-malarial activity in humans, the usefulness of an orally active chelator for this…”
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Loading dose of quinine in African children with cerebral malaria by Van Der Torn, Marein, Thuma, Philip E., Mabeza, George F., Biemba, Godfrey, Moyo, Victor M., Mclaren, Christine E., Brittenham, Gary M., Gordeuk, Victor R.

“…The majority of deaths from cerebral malaria occur within 48 h after admission to hospital. Because of the possibility of inadequate treatment within this…”
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Iron chelation therapy for malaria by Gordeuk, V R, Thuma, P E, Brittenham, G M

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Seasonality, blood feeding behavior, and transmission of Plasmodium falciparum by Anopheles arabiensis after an extended drought in southern Zambia by Kent, Rebekah J, Thuma, Philip E, Mharakurwa, Sungano, Norris, Douglas E

“…Transmission of Plasmodium falciparum is hyperendemic in southern Zambia. However, no data on the entomologic aspects of malaria transmission have been…”
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Factors associated with severe anaemia in Zambian children admitted with Plasmodium falciparum malarial anaemia by Mulenga, Modest, Malunga, Phidelis, Bennett, Steve, Thuma, Philip E., Shulman, Caroline, Fielding, Katherine, Greenwood, Brian M.

“…Many cases of severe malarial anaemia are clinically stable, but some can deteriorate rapidly. In a cross-sectional survey of 255 children with clinically…”
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A prospective study of combination antimalarial therapy and of anaemia in Zambian children with cerebral malaria by Dolmans, D. E. J. G. J., Thuma, P. E., Mabeza, G. F., Biemba, G., Parry, D., Mclaren, C. E., Gordeuk, V. R.

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Predictors of severity of illness on presentation in children with cerebral malaria by Mabeza, G F, Moyo, V M, Thuma, P E, Biemba, G, Parry, D, Khumalo, H, Nyarugwe, P, Zulu, S, Gordeuk, V R

“…The presenting features of 195 children with cerebral malaria were analysed to determine which correlated with severity of coma and anaemia. The children, who…”
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