Search Results - "Thum, Simone"

A modified pathway for the production of acetone in Escherichia coli by May, Antje, Fischer, Ralf-Jörg, Maria Thum, Simone, Schaffer, Steffen, Verseck, Stefan, Dürre, Peter, Bahl, Hubert

“…A modified synthetic acetone operon was constructed. It consists of two genes from Clostridium acetobutylicum (thlA coding for thiolase and adc coding for…”
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Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? by Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard

“…The influence of an F-atom in the side chain of benzo[7]annulen-7-amines on the affinity towards GluN2B subunit containing NMDA receptors and the selectivity…”
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Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity by Thum, Simone, Schepmann, Dirk, Ayet, Eva, Pujol, Marta, Nieto, Francisco R., Ametamey, Simon M., Wünsch, Bernhard

“…The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of…”
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Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety by Bergkemper, Melanie, Kronenberg, Elisabeth, Thum, Simone, Börgel, Frederik, Daniliuc, Constantin, Schepmann, Dirk, Nieto, Francisco Rafael, Brust, Peter, Reinoso, Raquel F, Alvarez, Inés, Wünsch, Bernhard

“…In order to detect novel σ receptor ligands, the rigid spiro[[2]­benzopyran-1,1′-cyclohexan]-4′-one was connected with amino moieties derived from σ2 receptor…”
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Replacement of the Benzylpiperidine Moiety with Fluorinated Phenylalkyl Side Chains for the Development of GluN2B Receptor Ligands by Thum, Simone, Schepmann, Dirk, Kalinin, Dmitrii V., Ametamey, Simon M., Wünsch, Bernhard

“…The 4‐benzylpiperidine moiety is a central structural element of potent N‐methyl‐d‐aspartate (NMDA) receptor antagonists containing the GluN2B subunit. To…”
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Synthesis and pharmacological evaluation of fluorinated benzoannulen‐7‐amines as GluN2B‐selective NMDA receptor antagonists by Thum, Simone, Schepmann, Dirk, Reinoso, Raquel F, Alvarez, Inés, Ametamey, Simon M, Wünsch, Bernhard

“…Because of their neuroprotective potential, GluN2B‐selective ligands are of great interest for the treatment of various neurological and neurodegenerative…”
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Synthesis and pharmacological evaluation of fluorinated benzo[7]annulen‐7‐amines as GluN2B‐selective NMDA receptor antagonists by Thum, Simone, Schepmann, Dirk, Reinoso, Raquel F., Alvarez, Inés, Ametamey, Simon M., Wünsch, Bernhard

“…Because of their neuroprotective potential, GluN2B‐selective ligands are of great interest for the treatment of various neurological and neurodegenerative…”
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A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors by Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard

“…N -methyl- D -aspartate receptors (NMDARs), especially GluN2B-containing NMDARs, are associated with neurodegenerative diseases like Parkinson, Alzheimer and…”
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Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold by Thum, Simone, Kokornaczyk, Artur K., Seki, Tomoaki, De Maria, Monica, Ortiz Zacarias, Natalia V., de Vries, Henk, Weiss, Christina, Koch, Michael, Schepmann, Dirk, Kitamura, Masato, Tschammer, Nuska, Heitman, Laura H., Junker, Anna, Wünsch, Bernhard

“…Targeting CCR2 and CCR5 receptors is considered as promising concept for the development of novel antiinflammatory drugs. Herein, we present the development of…”
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Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ 1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity by Thum, Simone, Schepmann, Dirk, Ayet, Eva, Pujol, Marta, Nieto, Francisco R, Ametamey, Simon M, Wünsch, Bernhard

“…The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of…”
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Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?The authors declare no competing interests.Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00621c by Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard

“…The influence of an F-atom in the side chain of benzo[7]annulen-7-amines on the affinity towards GluN2B subunit containing NMDA receptors and the selectivity…”
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Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?† †The authors declare no competing interests. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6md00621c by Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard

“…An F-atom in the phenylalkyl side chain of GluN2B antagonists does not affect the affinity towards GluN2B receptors. The influence of an F-atom in the side…”
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Molecular structure of a brominated 2-benzazepinone – a crucial intermediate in the synthesis of novel chemokine CCR2 receptor antagonists by Kokornaczyk, Artur K., Thum, Simone, Daniliuc, Constantin G., Junker, Anna, Wünsch, Bernhard

“…Chemokines (chemoattractant cytokines) together with their receptors represent key players in inflammatory processes. In order to develop novel chemokine CCR2…”
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A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors by Schreiber, Julian A, Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard

“…N-methyl-D-aspartate receptors (NMDARs), especially GluN2B-containing NMDARs, are associated with neurodegenerative diseases like Parkinson, Alzheimer and…”
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