Search Results - "Thullier, P"

Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering by Pelat, Thibaut, Bedouelle, Hugues, Rees, Anthony R., Crennell, Susan J., Lefranc, Marie-Paule, Thullier, Philippe

“…Fab 35PA83 is an antibody fragment of non-human primate origin that neutralizes the anthrax lethal toxin. Human antibodies are usually preferred when clinical…”
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Evaluation of an Immunochromatographic Test for Rapid and Reliable Serodiagnosis of Human Tularemia and Detection of Francisella tularensis-Specific Antibodies in Sera from Different Mammalian Species by Splettstoesser, W, Guglielmo-Viret, V, Seibold, E, Thullier, P

“…Tularemia is a highly contagious infectious zoonosis caused by the bacterial agent Francisella tularensis. Serology is still considered to be a cornerstone in…”
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Comparison of an electrochemiluminescence assay in plate format over a colorimetric ELISA, for the detection of ricin B chain (RCA-B) by Guglielmo-Viret, V., Thullier, P.

“…An electrochemiluminescence (ECL) assay for the detection of the B chain of ricin (RCA-B) in a 96-well plate format was developed in parallel with a…”
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Comparison of Hand-Held Test Kits, Immunofluorescence Microscopy, Enzyme-Linked Immunosorbent Assay, and Flow Cytometric Analysis for Rapid Presumptive Identification of Yersinia pestis by Tomaso, H, Thullier, P, Seibold, E, Guglielmo, V, Buckendahl, A, Rahalison, L, Neubauer, H, Scholz, H.C, Splettstoesser, W.D

“…An in-house immunochromatographic test, Plague BioThreat Alert test strips, ABICAP columns, enzyme-linked immunosorbent assay, flow cytometry, and…”
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Comparison of electrochemiluminescence assay and ELISA for the detection of Clostridium botulinum type B neurotoxin by Guglielmo-Viret, V., Attrée, O., Blanco-Gros, V., Thullier, P.

“…We compared the ELISA and electrochemiluminescence (ECL) immunoassay technologies for the detection of botulinum type B neurotoxin (BotNT B), which requires…”
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Nonhuman primates are relevant models for research in hematology, immunology and virology by Hérodin, F, Thullier, P, Garin, D, Drouet, M

“…Nonhuman primates have been used for biomedical research for several decades. They have proved to be models that are relevant to humans because of the high…”
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Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism by Thullier, Philippe, Demangel, Caroline, Bedouelle, Hugues, Megret, Francoise, Jouan, Alain, Deubel, Vincent, Mazie, Jean-Claude, Lafaye, Pierre

“…Laboratoire d’Ingénierie des Anticorps 1 , Unité de Biochimie Cellulaire 2 and Unité des Arbovirus et Virus des Fièvres Hémorragiques 3 , Institut Pasteur,…”
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P1159 In vitro evaluation of hand-held test kits, immunofiuores-cence microscopy, ELISA, andfiow cytometric analysis for the rapid presumptive identification of Yersinia pestis by Tomaso, H, Thullier, P, Seibold, E, Guglielmo, V, Buckendahl, A, Rahalison, L, Neubauer, H, Scholz, H, Splettstoesser, W

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A recombinant Fab neutralizes dengue virus in vitro by Thullier, P, Lafaye, P, Mégret, F, Deubel, V, Jouan, A, Mazié, J.C

“…A recombinant Fab that recognizes a neutralizing epitope located in the (296–400) region of protein E of dengue virus was obtained from cloned hybridoma cells…”
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Simulation of cardiovascular response to lower body negative pressure from 0 to -40 mmHg by Melchior, F M, Srinivasan, R S, Thullier, P H, Clère, J M

“…This paper presents a mathematical model for simulation of the human cardiovascular response to lower body negative pressure (LBNP) up to -40 mmHg both under…”
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Development and comparison of two immunoassay formats for rapid detection of botulinum neurotoxin type A by Attrée, Olivier, Guglielmo-Viret, Valérie, Gros, Valérie, Thullier, Philippe

“…We have evaluated two formats of immunoassays for the rapid detection of Clostridium botulinum neurotoxin type A (BoNT/A), in assay buffer and various matrices…”
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Isolation of a human-like antibody fragment (scFv) that neutralizes ricin biological activity by Pelat, Thibaut, Hust, Michael, Hale, Martha, Lefranc, Marie-Paule, Dübel, Stefan, Thullier, Philippe

“…Ricin is a lethal toxin that inhibits protein synthesis. It is easily extracted from a ubiquitously grown plant, Ricinus communis, and thus readily available…”
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Preliminary results of the AntiBotABE project: Identification of neutralizing scFvs antibodies against botulinum toxins A and B by Sesardic, D., Rasetti-Escargueil, C., Chahboun, S., Hust, M., Liu, Y., Pelat, T., Helmsing, S., Mérens, A., Jones, R.G.A., Thullier, P.

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Improvement of an Antibody Neutralizing the Anthrax Toxin by Simultaneous Mutagenesis of Its Six Hypervariable Loops by Laffly, Emmanuelle, Pelat, Thibaut, Cédrone, Frédéric, Blésa, Stéphane, Bedouelle, Hugues, Thullier, Philippe

“…The enhancement of antibody affinity by mutagenesis targeting only complementarity determining regions has the advantage of respecting the framework regions,…”
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Single administration of stem cell factor, FLT-3 ligand, megakaryocyte growth and development factor, and interleukin-3 in combination soon after irradiation prevents nonhuman primates from myelosuppression: long-term follow-up of hematopoiesis by Drouet, Michel, Mourcin, Frédéric, Grenier, Nancy, Leroux, Valérie, Denis, Josianne, Mayol, Jean-François, Thullier, Philippe, Lataillade, Jean-Jacques, Herodin, Francis

“…Preservation of hematopoietic stem and progenitor cell survival is required for recovery from radiation-induced myelosuppression. We recently showed that…”
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Selection of a Macaque Fab with Framework Regions Like Those in Humans, High Affinity, and Ability To Neutralize the Protective Antigen (PA) of Bacillus anthracis by Binding to the Segment of PA between Residues 686 and 694 by LAFFLY, Emmanuelle, DANJOU, Ludivine, CONDEMINE, Florence, VIDAL, Dominique, DROUET, Emmanuel, LEFRANC, Marie-Paule, BOTTEX, Chantal, THULLIER, Philippe

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Short report: Serodiagnosis of plague in humans and rats using a rapid test by Thullier, Philippe, Guglielmo, Valerie, Rajerison, Mino, Chanteau, Suzanne

“…Serodiagnosis of plague is very useful for its retrospective confirmation and for epidemiologic studies in humans and in rodents, since rats constitute the…”
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An Immunochromatographic Test for the Diagnosis of Ricin Inhalational Poisoning by Guglielmo-Viret, Valérie, Splettstoesser, Wolf, Thullier, Philippe

“…Introduction. Aerosolized ricin is a feared bioweapon for which no diagnostic protocol is currently available. Methods. We obtained antibodies to develop an…”
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A high affinity, human-like antibody fragment (scFv) neutralising the lethal factor (LF) of Bacillus anthracis by inhibiting PA-LF complex formation by Pelat, T., Hust, M., Laffly, E., Condemine, F., Bottex, C., Vidal, D., Lefranc, Mp, Dubel, S., Thullier, P.

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A high-affinity macaque antibody Fab with human-like framework regions obtained from a small phage display immune library by Chassagne, Stéphanie, Laffly, Emmanuelle, Drouet, Emmanuel, Hérodin, Francis, Lefranc, Marie-Paule, Thullier, Philippe

“…Tetanus toxoid was used as a model antigen for the immunization of Macaca fascicularis. Using peripheral blood as a template, specific Fab-encoding genes were…”
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