Search Results - "Thuita, John K."

Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys by Thuita, John K, Wolf, Kristina K, Murilla, Grace A, Bridges, Arlene S, Boykin, David W, Mutuku, James N, Liu, Qiang, Jones, Susan K, Gem, Charles O, Ching, Shelley, Tidwell, Richard R, Wang, Michael Z, Paine, Mary F, Brun, Reto

“…Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe…”
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Differential virulence and tsetse fly transmissibility of Trypanosoma congolense and Trypanosoma brucei strains by Murilla, Grace A., Wamwiri, Florence N., Ndung’u, Kariuki, Ngae, Geoffrey N., Thande, Paul C., Auma, Joanna E., Kurgat, Richard, Kibugu, James K., Thuita, John K., Gitonga, Purity K.

“…African animal trypanosomiasis causes significant economic losses in sub-Saharan African countries because of livestock mortalities and reduced productivity…”
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Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis by Thuita, John K, Wang, Michael Z, Kagira, John M, Denton, Cathrine L, Paine, Mary F, Mdachi, Raymond E, Murilla, Grace A, Ching, Shelley, Boykin, David W, Tidwell, Richard R, Hall, James E, Brun, Reto

“…Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite the recent addition of nifurtimox-eflornithine combination therapy…”
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Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis by Thuita, John K, Wolf, Kristina K, Murilla, Grace A, Liu, Qiang, Mutuku, James N, Chen, Yao, Bridges, Arlene S, Mdachi, Raymond E, Ismail, Mohamed A, Ching, Shelley, Boykin, David W, Hall, James Edwin, Tidwell, Richard R, Paine, Mary F, Brun, Reto, Wang, Michael Zhuo

“…There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the…”
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Kenya Trypanosomiasis Research Institute cryobank for human and animal trypanosome isolates to support research: opportunities and challenges by Murilla, Grace A, Ndung'u, Kariuki, Thuita, John K, Gitonga, Purity K, Kahiga, Daniel T, Auma, Joanna E, Ouma, Johnson O, Rutto, Jane J, Ndung'u, Joseph M

“…  The WHO steering committee on human African trypanosomiasis treatment and the East African Network for Tsetse and Trypanosomiasis (EANETT) have therefore…”
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Trypanosoma brucei rhodesiense transmitted by a single tsetse fly bite in vervet monkeys as a model of human African trypanosomiasis by Thuita, John K, Kagira, John M, Mwangangi, David, Matovu, Enock, Turner, C M R, Masiga, Daniel

“…We have investigated the pathogenicity of tsetse (Glossina pallidipes)-transmitted cloned strains of Trypanosoma brucei rhodesiense in vervet monkeys. Tsetse…”
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Diamidines for human African trypanosomiasis by Paine, Mary F, Wang, Michael Zhuo, Generaux, Claudia N, Boykin, David W, Wilson, W David, De Koning, Harry P, Olson, Carol A, Pohlig, Gabriele, Burri, Christian, Brun, Reto, Murilla, Grace A, Thuita, John K, Barrett, Michael P, Tidwell, Richard R

“…Aromatic diamidines are potent trypanocides. Pentamidine, a diamidine, has been used for more than 60 years to treat human African trypanosomiasis (HAT);…”
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Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense by Ngotho, Maina, Kagira, John M., Kariuki, Christopher, Maina, Naomi, Thuita, John K., Mwangangi, David M., Farah, Idle O., Hau, Jann

“…Vervet monkeys in an outdoor group cage at IPR. [Display omitted] ► Haematological changes were characterized using the vervet monkey model of T. b…”
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Kenya Trypanosomiasis Research Institute Cryobank for Human and Animal Trypanosome Isolates to Support Research: Opportunities and Challenges: e2747 by Murilla, Grace A, Thuita, John K, Gitonga, Purity K, Kahiga, Daniel T, Auma, Joanna E, Ouma, Johnson O, Rutto, Jane J

“…The WHO steering committee on human African trypanosomiasis treatment and the East African Network for Tsetse and Trypanosomiasis (EANETT) have therefore…”
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Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys: e0003409 by Thuita, John K, Wolf, Kristina K, Murilla, Grace A, Bridges, Arlene S, Boykin, David W, Mutuku, James N, Liu, Qiang, Jones, Susan K, Gem, Charles O, Ching, Shelley, Tidwell, Richard R, Wang, Michael Z, Paine, Mary F, Brun, Reto

“…Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe…”
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Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis: e2230 by Thuita, John K, Wolf, Kristina K, Murilla, Grace A, Liu, Qiang, Mutuku, James N, Chen, Yao, Bridges, Arlene S, Echi, Raymond, Ismail, Mohamed A, Ching, Shelley, Boykin, David W, Hall, James Edwin, Tidwell, Richard R, Paine, Mary F, Brun, Reto, Wang, Michael Zhuo

“…There are no oral drugs for human African trypanosomiasis (HAT, sleeping sickness). A successful oral drug would have the potential to reduce or eliminate the…”
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Haematology of Experimental Trypanosoma Brucei Rhodesiense Infection in Vervet Monkeys by Kagira, John M, Thuita, John K, Ngotho, Maina, Mdachi, Raymond, Mwangangi, David M, Ndung'u, Joseph M

“…Haematological aberrations associated with human infective trypanosomes were investigated in the vervet monkey model of the Rhodesian sleeping sickness. Four…”
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