Search Results - "Thuillet, Raphael"

Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension by Tamura, Yuichi, Phan, Carole, Tu, Ly, Le Hiress, Morane, Thuillet, Raphaël, Jutant, Etienne-Marie, Fadel, Elie, Savale, Laurent, Huertas, Alice, Humbert, Marc, Guignabert, Christophe

“…Pulmonary arterial hypertension (PAH) is characterized by a progressive accumulation of pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterioles…”
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Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension by Tu, Ly, Desroches-Castan, Agnès, Mallet, Christine, Guyon, Laurent, Cumont, Amélie, Phan, Carole, Robert, Florian, Thuillet, Raphaël, Bordenave, Jennifer, Sekine, Ayumi, Huertas, Alice, Ritvos, Olli, Savale, Laurent, Feige, Jean-Jacques, Humbert, Marc, Bailly, Sabine, Guignabert, Christophe

“…RATIONALE:Although many familial cases of pulmonary arterial hypertension exhibit an autosomal dominant mode of inheritance with the majority having mutations…”
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Proinflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension. Role of the Macrophage Migration Inhibitory Factor/CD74 Complex by Le Hiress, Morane, Tu, Ly, Ricard, Nicolas, Phan, Carole, Thuillet, Raphaël, Fadel, Elie, Dorfmüller, Peter, Montani, David, de Man, Frances, Humbert, Marc, Huertas, Alice, Guignabert, Christophe

“…Inflammation and endothelial dysfunction are considered two primary instigators of pulmonary arterial hypertension (PAH). CD74 is a receptor for the…”
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Neutralization of CXCL12 attenuates established pulmonary hypertension in rats by Bordenave, Jennifer, Thuillet, Raphaël, Tu, Ly, Phan, Carole, Cumont, Amélie, Marsol, Claire, Huertas, Alice, Savale, Laurent, Hibert, Marcel, Galzi, Jean-Luc, Bonnet, Dominique, Humbert, Marc, Frossard, Nelly, Guignabert, Christophe

“…Abstract Aims  The progressive accumulation of cells in pulmonary vascular walls is a key pathological feature of pulmonary arterial hypertension (PAH) that…”
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Increased Pericyte Coverage Mediated by Endothelial-Derived Fibroblast Growth Factor-2 and Interleukin-6 Is a Source of Smooth Muscle–Like Cells in Pulmonary Hypertension by Ricard, Nicolas, Tu, Ly, Le Hiress, Morane, Huertas, Alice, Phan, Carole, Thuillet, Raphaël, Sattler, Caroline, Fadel, Elie, Seferian, Andrei, Montani, David, Dorfmüller, Peter, Humbert, Marc, Guignabert, Christophe

“…BACKGROUND—Pericytes and their crosstalk with endothelial cells are critical for the development of a functional microvasculature and vascular remodeling. It…”
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Dasatinib increases endothelial permeability leading to pleural effusion by Phan, Carole, Jutant, Etienne-Marie, Tu, Ly, Thuillet, Raphaël, Seferian, Andrei, Montani, David, Huertas, Alice, Bezu, Jan van, Breijer, Fabian, Vonk Noordegraaf, Anton, Humbert, Marc, Aman, Jurjan, Guignabert, Christophe

“…Pleural effusion is a frequent side-effect of dasatinib, a second-generation tyrosine kinase inhibitor used in the treatment of chronic myelogenous leukaemia…”
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Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension by Guignabert, Christophe, Phan, Carole, Seferian, Andrei, Huertas, Alice, Tu, Ly, Thuillet, Raphaël, Sattler, Caroline, Le Hiress, Morane, Tamura, Yuichi, Jutant, Etienne-Marie, Chaumais, Marie-Camille, Bouchet, Stéphane, Manéglier, Benjamin, Molimard, Mathieu, Rousselot, Philippe, Sitbon, Olivier, Simonneau, Gérald, Montani, David, Humbert, Marc

“…Pulmonary arterial hypertension (PAH) is a life-threatening disease that can be induced by dasatinib, a dual Src and BCR-ABL tyrosine kinase inhibitor that is…”
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Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension by Savale, Laurent, Akagi, Satoshi, Tu, Ly, Cumont, Amélie, Thuillet, Raphaël, Phan, Carole, Le Vely, Benjamin, Berrebeh, Nihel, Huertas, Alice, Jaïs, Xavier, Cottin, Vincent, Chaouat, Ari, Tromeur, Cécile, Boucly, Athénaïs, Jutant, Etienne Marie, Mercier, Olaf, Fadel, Elie, Montani, David, Sitbon, Olivier, Humbert, Marc, Tamura, Yuichi, Guignabert, Christophe

“…Earlier studies have suggested an association between uric acid (UA) and pulmonary arterial hypertension (PAH) severity, but it remains unknown whether UA…”
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Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension by Bordenave, Jennifer, Tu, Ly, Berrebeh, Nihel, Thuillet, Raphaël, Cumont, Amélie, Le Vely, Benjamin, Fadel, Elie, Nadaud, Sophie, Savale, Laurent, Humbert, Marc, Huertas, Alice, Guignabert, Christophe

“…OBJECTIVE:Excessive accumulation of resident cells within the pulmonary vascular wall represents the hallmark feature of the remodeling occurring in pulmonary…”
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Effects of B Cell Depletion by CD19-Targeted Chimeric Antigen Receptor T Cells in a Murine Model of Systemic Sclerosis by Avouac, Jérôme, Cauvet, Anne, Orvain, Cindy, Boulch, Morgane, Tilotta, Françoise, Tu, Ly, Thuillet, Raphaël, Ottaviani, Mina, Guignabert, Christophe, Bousso, Philippe, Allanore, Yannick

“…Our goal was to study the tolerance and efficacy of two B cell depletion strategies, including one with CD19-targeted chimeric antigen receptor (CAR) T cells,…”
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Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats by Tu, Ly, Thuillet, Raphaël, Perrot, Julie, Ottaviani, Mina, Ponsardin, Emy, Kolkhof, Peter, Humbert, Marc, Viengchareun, Say, Lombès, Marc, Guignabert, Christophe

“…BACKGROUNDWe studied the ability of the nonsteroidal MR (mineralocorticoid receptor) antagonist finerenone to attenuate vascular remodeling and pulmonary…”
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Additive protective effects of sacubitril/valsartan and bosentan on vascular remodelling in experimental pulmonary hypertension by Chaumais, Marie-Camille, Djessas, Mohamed Reda Amar, Thuillet, Raphaël, Cumont, Amélie, Tu, Ly, Hebert, Guillaume, Gaignard, Pauline, Huertas, Alice, Savale, Laurent, Humbert, Marc, Guignabert, Christophe

“…Abstract Aims Although right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension…”
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Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis by Cauvet, Anne, Decellas, Arthur, Guignabert, Christophe, Rongvaux-Gaïda, Dominique, Thuillet, Raphaël, Ottaviani, Mina, Tu, Ly, Rieger, François, Avouac, Jérôme, Allanore, Yannick

“…Background Uncontrolled T-cell activation plays a key role in systemic sclerosis (SSc). Arsenic trioxide (ATO) has immunological effects and has demonstrated…”
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Regulatory T Cell Dysfunction in Idiopathic, Heritable and Connective Tissue-Associated Pulmonary Arterial Hypertension by Huertas, Alice, MD, PhD, Phan, Carole, MS, Bordenave, Jennifer, MS, Tu, Ly, PhD, Thuillet, Raphaël, BS, Le Hiress, Morane, PhD, Avouac, Jérôme, MD, PhD, Tamura, Yuichi, MD, PhD, Allanore, Yannick, MD, PhD, Jovan, Roland, MD, Sitbon, Olivier, MD, PhD, Guignabert, Christophe, PhD, Humbert, Marc, MD, PhD

“…Background Pulmonary arterial hypertension (PAH) encompasses a group of conditions with distinct causes. Immunologic disorders are common features of all forms…”
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Leptin signalling system as a target for pulmonary arterial hypertension therapy by Huertas, Alice, Tu, Ly, Thuillet, Raphaël, Le Hiress, Morane, Phan, Carole, Ricard, Nicolas, Nadaud, Sophie, Fadel, Elie, Humbert, Marc, Guignabert, Christophe

“…Excessive proliferation of pulmonary arterial smooth muscle cells (PA-SMCs) and perivascular inflammation lead to pulmonary arterial hypertension (PAH)…”
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AMPK activation by metformin protects against pulmonary hypertension in rats and relaxes isolated human pulmonary artery by Abdelazeem, Heba, Tu, Ly, Thuillet, Raphaël, Ottaviani, Mina, Boulfrad, Achraf, Beck, Thomas, Senbel, Amira, Mani, Salma, Castier, Yves, Guyard, Alice, Tran-Dinh, Alexy, El-Benna, Jamel, Longrois, Dan, Silverstein, Adam M., Guignabert, Christophe, Norel, Xavier

“…Pulmonary hypertension (PH) is associated with pulmonary vasoconstriction and endothelial dysfunction leading to impaired nitric oxide (NO) and prostacyclin…”
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Serum and Pulmonary Expression Profiles of the Activin Signaling System in Pulmonary Arterial Hypertension by Guignabert, Christophe, Savale, Laurent, Boucly, Athénaïs, Thuillet, Raphaël, Tu, Ly, Ottaviani, Mina, Rhodes, Christopher J., De Groote, Pascal, Prévot, Grégoire, Bergot, Emmanuel, Bourdin, Arnaud, Howard, Luke S., Fadel, Elie, Beurnier, Antoine, Roche, Anne, Jevnikar, Mitja, Jaïs, Xavier, Montani, David, Wilkins, Martin R., Sitbon, Olivier, Humbert, Marc

“…Activins are novel therapeutic targets in pulmonary arterial hypertension (PAH). We therefore studied whether key members of the activin pathway could be used…”
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Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models by Orvain, Cindy, Cauvet, Anne, Prudent, Alexis, Guignabert, Christophe, Thuillet, Raphaël, Ottaviani, Mina, Tu, Ly, Duhalde, Fanny, Nicco, Carole, Batteux, Frédéric, Avouac, Jérôme, Wang, NingXin, Seaberg, Michelle A, Dillon, Stacey R, Allanore, Yannick

“…Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by…”
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Driving Role of Interleukin‐2–Related Regulatory CD4+ T Cell Deficiency in the Development of Lung Fibrosis and Vascular Remodeling in a Mouse Model of Systemic Sclerosis by Frantz, Camelia, Cauvet, Anne, Durand, Aurélie, Gonzalez, Virginie, Pierre, Rémi, Do Cruzeiro, Marcio, Bailly, Karine, Andrieu, Muriel, Orvain, Cindy, Avouac, Jérôme, Ottaviani, Mina, Thuillet, Raphaël, Tu, Ly, Guignabert, Christophe, Lucas, Bruno, Auffray, Cédric, Allanore, Yannick

“…Objective Systemic sclerosis (SSc) is a debilitating autoimmune disease characterized by severe lung outcomes resulting in reduced life expectancy…”
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Central role of ubiquitin-specific protease 8 in leptin signaling pathway in pulmonary arterial hypertension by Jutant, Etienne-Marie, Chelgham, Mustapha K., Ottaviani, Mina, Thuillet, Raphaël, Le Vely, Benjamin, Humbert, Marc, Guignabert, Christophe, Tu, Ly, Huertas, Alice

“…Leptin receptor (ObR-b) is overexpressed in pulmonary artery smooth muscle cells (PA-SMCs) from patients with pulmonary arterial hypertension (PAH) and is…”
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