Search Results - "Thudium, C. S."

Disruption of the V-ATPase functionality as a way to uncouple bone formation and resorption - a novel target for treatment of osteoporosis by Thudium, C S, Jensen, V K, Karsdal, M A, Henriksen, K

“…The unique ability of the osteoclasts to resorb the calcified bone matrix is dependent on secretion of hydrochloric acid. This process is mediated by a…”
Get more information

A machine learning approach for the identification of new biomarkers for knee osteoarthritis development in overweight and obese women by Lazzarini, N., Runhaar, J., Bay-Jensen, A.C., Thudium, C.S., Bierma-Zeinstra, S.M.A., Henrotin, Y., Bacardit, J.

“…Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease…”
Get full text

Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria by Bay-Jensen, A.C, Reker, D, Kjelgaard-Petersen, C.F, Mobasheri, A, Karsdal, M.A, Ladel, C, Henrotin, Y, Thudium, C.S

“…Summary Objective To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of…”
Get full text

Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors by Sharma, N., Drobinski, P., Kayed, A., Chen, Z., Kjelgaard-Petersen, C.F., Gantzel, T., Karsdal, M.A., Michaelis, M., Ladel, C., Bay-Jensen, A.C., Lindemann, S., Thudium, C.S.

“…Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in…”
Get full text

Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo by Reker, D., Siebuhr, A. S., Thudium, C. S., Gantzel, T., Ladel, C., Michaelis, M., Aspberg, A., Berchtold, M. W., Karsdal, M. A., Gigout, A., Bay-Jensen, A. C.

“…Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We…”
Get full text

A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model by Katri, A., Dąbrowska, A., Löfvall, H., Karsdal, M.A., Andreassen, K.V., Thudium, C.S., Henriksen, K.

“…Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for…”
Get full text

IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3 by van Geffen, E.W., van Caam, A.P.M., Schreurs, W., van de Loo, F.A., van Lent, P.L.E.M., Koenders, M.I., Thudium, C.S., Bay-Jensen, A.C., Blaney Davidson, E.N., van der Kraan, P.M.

“…A hallmark of osteoarthritis (OA) is degradation of articular cartilage proteoglycans. In isolated human OA chondrocytes, the anti-inflammatory cytokine…”
Get full text

A case report of pregnancy in untreated alkaptonuria – Focus on urinary tissue remodelling markers by Ranganath, L.R., Milan, A.M., Bay-Jensen, A.C., Thudium, C.S.

“…A 34-year old woman with alkaptonuria had an elective pregnancy, during which she collected urine samples over the duration of her pregnancy until parturition…”
Get full text

Colony housing promotes structural and functional changes during surgically induced osteoarthritis in rats by Brenneis, C., Menges, S., Westhof, A., Lindemann, S., Thudium, C.S., Kleinschmidt-Doerr, K.

“…The aim of the study was to investigate how social housing with high locomotion activity affects experimental osteoarthritis (OA) in rats. Rats were housed…”
Get full text

Type IV collagen metabolism is associated with disease activity, radiographic progression and response to tocilizumab in rheumatoid arthritis by Gudmann, Natasja Stæhr, Junker, Peter, Juhl, Pernille, Thudium, Christian Schneider, Siebuhr, Anne Sofie, Byrjalsen, Inger, Karsdal, Morten Asser, Bay-Jensen, Anne Christine

“…The expanding spectrum of targeted therapies for rheumatoid arthritis (RA) implies a need for development of precision tools for disease assessment reflecting…”
Get full text

Bone marrow lesions are associated with pain, but not with inflammatory biomarkers in end-stage knee osteoarthritis patients by Radojčić, M.R, Thudium, C.S, Henriksen, K, Tan, K, Karlsten, R, Dudley, A, Chessell, I, Karsdal, M.A, Bay-Jensen, A.-C, Crema, M.D, Guermazi, A

Get full text

Osteoclasts are not crucial for hematopoietic stem cell maintenance in adult mice by Flores, Carmen, Moscatelli, Ilana, Thudium, Christian S, Gudmann, Natasja Stæhr, Thomsen, Jesper S, Brüel, Annemarie, Karsdal, Morten A, Henriksen, Kim, Richter, Johan

“…The osteoclast is vital for establishment of normal hematopoiesis in the developing animal. However, its role for maintenance of hematopoiesis in adulthood is…”
Get full text

Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model by Katri, Anna, Dąbrowska, Aneta, Löfvall, Henrik, Ding, Ming, Karsdal, Morten A, Andreassen, Kim V, Thudium, Christian S, Henriksen, Kim

“…Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory…”
Get full text

Effect of Naproxen and KBP-056 in a collagen induced arthritis rat model of arthritic pain by Katri, A, Löfvall, H, Karsdal, M.A, Thudium, C.S, Henriksen, K

Get full text

A case report of pregnancy in untreated alkaptonuria - Focus on urinary tissue remodelling markers by Ranganath, L R, Milan, A M, Bay-Jensen, A C, Thudium, C S

Get full text