Search Results - "Thudium, C."

A machine learning approach for the identification of new biomarkers for knee osteoarthritis development in overweight and obese women by Lazzarini, N., Runhaar, J., Bay-Jensen, A.C., Thudium, C.S., Bierma-Zeinstra, S.M.A., Henrotin, Y., Bacardit, J.

“…Knee osteoarthritis (OA) is among the higher contributors to global disability. Despite its high prevalence, currently, there is no cure for this disease…”
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Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria by Bay-Jensen, A.C, Reker, D, Kjelgaard-Petersen, C.F, Mobasheri, A, Karsdal, M.A, Ladel, C, Henrotin, Y, Thudium, C.S

“…Summary Objective To review and summarize biomarker data published from April 2014 to May 2015 to provide insight to the ongoing work in the field of…”
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Inflammation and joint destruction may be linked to the generation of cartilage metabolites of ADAMTS-5 through activation of toll-like receptors by Sharma, N., Drobinski, P., Kayed, A., Chen, Z., Kjelgaard-Petersen, C.F., Gantzel, T., Karsdal, M.A., Michaelis, M., Ladel, C., Bay-Jensen, A.C., Lindemann, S., Thudium, C.S.

“…Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in…”
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Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo by Reker, D., Siebuhr, A. S., Thudium, C. S., Gantzel, T., Ladel, C., Michaelis, M., Aspberg, A., Berchtold, M. W., Karsdal, M. A., Gigout, A., Bay-Jensen, A. C.

“…Sprifermin, recombinant human fibroblast growth factor 18 (rhFGF18), induces cartilage regeneration in knees of patients with osteoarthritis (OA). We…”
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A dual amylin and calcitonin receptor agonist inhibits pain behavior and reduces cartilage pathology in an osteoarthritis rat model by Katri, A., Dąbrowska, A., Löfvall, H., Karsdal, M.A., Andreassen, K.V., Thudium, C.S., Henriksen, K.

“…Pain and disability are the main clinical manifestations of osteoarthritis, for which only symptomatic therapies are available. Hence, there is a need for…”
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Disruption of the V-ATPase functionality as a way to uncouple bone formation and resorption - a novel target for treatment of osteoporosis by Thudium, C S, Jensen, V K, Karsdal, M A, Henriksen, K

“…The unique ability of the osteoclasts to resorb the calcified bone matrix is dependent on secretion of hydrochloric acid. This process is mediated by a…”
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Anabolic Induction of Cartilage Can be Achieved in Novel Bovine Explant Models of Cartilage and Synovial Membrane by TGF-β1 by Siebuhr, A, Dahab, S, Cabañes, C. Arco, Bay-Jensen, A.-C, Thudium, C

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IL-37 diminishes proteoglycan loss in human OA cartilage: donor-specific link between IL-37 and MMP-3 by van Geffen, E.W., van Caam, A.P.M., Schreurs, W., van de Loo, F.A., van Lent, P.L.E.M., Koenders, M.I., Thudium, C.S., Bay-Jensen, A.C., Blaney Davidson, E.N., van der Kraan, P.M.

“…A hallmark of osteoarthritis (OA) is degradation of articular cartilage proteoglycans. In isolated human OA chondrocytes, the anti-inflammatory cytokine…”
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Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA by Bay-Jensen, A.-C, Bihlet, A, Byrjalsen, I, Andersen, J, He, Y, Siebuhr, A, Thudium, C, Guehring, H, Michaelis, M, Ladel, C, Juel Riis, B, Christiansen, C, Karsdal, M.A

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Elevated levels of CRPM, an inflammatory biomarker correlating with disease activity in RA, are prognostic of radiographic knee OA by Bay-Jensen, A.-C, Bihlet, A, Byrjalsen, I, Andersen, J, He, Y, Siebuhr, A, Thudium, C, Guehring, H, Michaelis, M, Ladel, C, Juel Riis, B, Christiansen, C, Karsdal, M.A

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A case report of pregnancy in untreated alkaptonuria – Focus on urinary tissue remodelling markers by Ranganath, L.R., Milan, A.M., Bay-Jensen, A.C., Thudium, C.S.

“…A 34-year old woman with alkaptonuria had an elective pregnancy, during which she collected urine samples over the duration of her pregnancy until parturition…”
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Colony housing promotes structural and functional changes during surgically induced osteoarthritis in rats by Brenneis, C., Menges, S., Westhof, A., Lindemann, S., Thudium, C.S., Kleinschmidt-Doerr, K.

“…The aim of the study was to investigate how social housing with high locomotion activity affects experimental osteoarthritis (OA) in rats. Rats were housed…”
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Cartilage-Bound Large Multilamellar Liposomes Show Potential Cartilage Protection From Inflammatory Stimulus By Attenuating Aggrecan Degradation by Wechsler, R., Thudium, C.

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Human cord blood CD34+ cells transduced by a lentiviral marking vector can be differentiated into functional GFP expressing osteoclasts at high efficiency by Thudium, C, Moscatelli, I, Flores, C, Richter, J, Henriksen, K

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Baseline Levels Of The Soluble Biomarkers Pro-C2 And Crpm Are Associated With Pain Trajectories In Knee Osteoarthritis by Bay-Jensen, A-C., Thudium, C., Sinkeviciute, D., He, Y., Karsdal, M.

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Compressive loading improves the effect of insulin-like growth factor-1 in promoting type II collagen formation in bovine cartilage explants by Engstrøm, A., Bay-Jensen, A.-C., Karsdal, M., Thudium, C.

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Relevance Of Biomarkers In Serum Vs Synovial Fluid In Patients With Knee Osteoarthritis by Kalogera, S., Jansen, M., Bay Jensen, A.-C., Frederiksen, P., Karsdal, M., Lafeber, F., Mastbergen, S., Thudium, C.

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Long term intermittent compression of articular cartilage attenuates cartilage degradation by Engstrøm, A., Bay-Jensen, A.-C., Karsdal, M., Thudium, C.

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Deconstructing biomarker analysis in OA: activity, burden of disease and progression by Bay-Jensen, A.-C., Bihlet, A., Thudium, C., Andersen, J.R., Karsdal, M.A.

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The anti-ADAMTS-5 nanobody®, M6495, inhibits the activation of TLR by ADAMTS-5-mediated degradation fragments in cartilage explants by Sharma, N., Drobinski, P., Karsdal, M., Bay-Jensen, A.-C., Thudium, C., Michaelis, M., Ladel, C., Lindemann, S.

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