Search Results - "Thrun, L."

Mammalian SNM1 is required for genome stability by Hemphill, A.W., Bruun, D., Thrun, L., Akkari, Y., Torimaru, Y., Hejna, K., Jakobs, P.M., Hejna, J., Jones, S., Olson, S.B., Moses, R.E.

“…The protein encoded by SNM1 in Saccharomyces cerevisiae has been shown to act specifically in DNA interstrand crosslinks (ICL) repair. There are five mammalian…”
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Estradiol Requirements for Induction and Maintenance of the Gonadotropin-Releasing Hormone Surge: Implications for Neuroendocrine Processing of the Estradiol Signal by Evans, N. P., Dahl, G. E., Padmanabhan, V., Thrun, L. A., Karsch, F. J.

“…Abstract Two experiments were performed to examine the temporal requirements of the estradiol signal for the GnRH and LH surges in the ewe. Hypophyseal portal…”
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Importance of Photoperiodic Signal Quality to Entrainment of the Circannual Reproductive Rhythm of the Ewe by BARRELL, Graham K, THRUN, Lori A, BROWN, Martha E, VIGUIE, Catherine, KARSCH, Fred J

“…An endogenous circannual rhythm drives the seasonal reproductive cycle of a broad spectrum of species. This rhythm is synchronized to the seasons (i.e.,…”
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Thyroxine is permissive to seasonal transitions in reproductive neuroendocrine activity in the ewe by Dahl, G.E. (University of Michigan, Ann Arbor, MI.), Evans, N.P, Thrun, L.A, Karsch, F.J

“…The observation that circulating thyroxine concentration increases during the breeding season of the ewe, coupled with the finding that thyroid hormones are…”
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A Critical Period for Thyroid Hormone Action on Seasonal Changes in Reproductive Neuroendocrine Function in the Ewe by Thrun, L. A., Dahl, G. E., Evans, N. P., Karsch, F. J.

“…Abstract Thyroid hormones are obligatory for the annually recurring termination of reproductive activity in a spectrum of seasonal breeders, including sheep…”
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Progesterone blocks the estradiol-induced gonadotropin discharge in the ewe by inhibiting the surge of gonadotropin-releasing hormone by Kasa-Vubu, J Z, Dahl, G E, Evans, N P, Thrun, L A, Moenter, S M, Padmanabhan, V, Karsch, F J

“…Previous studies indicate an elevation of circulating progesterone blocks the positive feedback effect of a rise in circulating estradiol. This explains the…”
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Does estradiol induce the preovulatory gonadotropin-releasing hormone (GnRH) surge in the ewe by inducing a progressive change in the mode of operation of the GnRH neurosecretory system by Evans, N P, Dahl, G E, Mauger, D T, Padmanabhan, V, Thrun, L A, Karsch, F J

“…Estradiol profoundly influences GnRH secretion during the follicular phase of the estrous cycle of the sheep. Estradiol not only regulates the frequency and…”
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Time-course of thyroid hormone involvement in the development of anestrus in the ewe by Thrun, L.A. (University of Michigan, Ann Arbor, MI.), Dahl, G.E, Evans, N.P, Karsch, F.J

“…It is well established that the thyroid gland is essential for termination of seasonal reproductive activity in a variety of birds and mammals. In the present…”
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Endotoxin inhibits the reproductive neuroendocrine axis while stimulating adrenal steroids: a simultaneous view from hypophyseal portal and peripheral blood by Battaglia, D F, Bowen, J M, Krasa, H B, Thrun, L A, Viguié, C, Karsch, F J

“…This study was designed to test the hypothesis that systemic immune challenge with endotoxin inhibits the reproductive axis centrally by suppressing GnRH…”
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Effect of thyroidectomy on maintenance of seasonal reproductive suppression in the ewe by Thrun, L.A, Dahl, G.E, Evans, N.P, Karsch, F.J

“…Thyroid hormones are essential to end the breeding season in sheep; however, it is not clear whether thyroid hormone action is limited to initiation of…”
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Systemic challenge with endotoxin stimulates corticotropin-releasing hormone and arginine vasopressin secretion into hypophyseal portal blood: coincidence with gonadotropin-releasing hormone suppression by Battaglia, D F, Brown, M E, Krasa, H B, Thrun, L A, Viguié, C, Karsch, F J

“…We tested the hypothesis that systemic immune/inflammatory challenge (endotoxin) activates the neuroendocrine stress axis centrally by stimulating the…”
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A critical period for thyroid hormone action on seasonal changes in reproductive neuroendocrine function in the ewe by Thrun, L A, Dahl, G E, Evans, N P, Karsch, F J

“…Thyroid hormones are obligatory for the annually recurring termination of reproductive activity in a spectrum of seasonal breeders, including sheep. Previous…”
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Thyroid hormones act primarily within the brain to promote the seasonal inhibition of luteinizing hormone secretion in the ewe by Viguié, C, Battaglia, D F, Krasa, H B, Thrun, L A, Karsch, F J

“…In the ewe, thyroid hormones are required for the seasonal suppression of GnRH and LH secretion, thereby maintaining an annual rhythm in reproductive activity…”
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Involvement of thyroid hormones in seasonal reproduction by Karsch, F J, Dahl, G E, Hachigian, T M, Thrun, L A

“…This article reviews experiments performed to investigate the importance of thyroid hormones to the expression of the seasonal reproductive cycle of ewes…”
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Efficacy after sequencing of brain radiotherapy and enhanced antibody targeted chemotherapy delivery in a rodent human lung cancer brain xenograft model by Remsen, L G, Marquez, C, Garcia, R, Thrun, L A, Neuwelt, E A

“…The objective of this study was to evaluate the efficacy of sequencing radiation therapy (RT) and antibody targeted chemotherapy (BR96-DOX) in nude rats…”
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Circannual alterations in the circadian rhythm of melatonin secretion by Thrun, L A, Moenter, S M, O'Callaghan, D, Woodfill, C J, Karsch, F J

“…To determine if a circadian rhythm known to be functionally related to the reproductive axis varies on a circannual basis, we monitored the circadian secretion…”
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Importance of the gonadotropin-releasing hormone (GnRH) surge for induction of the preovulatory luteinizing hormone surge of the ewe: dose-response relationship and excess of GnRH by Bowen, J M, Dahl, G E, Evans, N P, Thrun, L A, Wang, Y, Brown, M B, Karsch, F J

“…The preovulatory LH surge in the ewe is stimulated by a large sustained surge of GnRH. We have previously demonstrated that the duration of this GnRH signal…”
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How much of the gonadotropin-releasing hormone (GnRH) surge is required for generation of the luteinizing hormone surge in the ewe? Duration of the endogenous GnRH signal by Evans, N P, Dahl, G E, Caraty, A, Padmanabhan, V, Thrun, L A, Karsch, F J

“…The preovulatory LH surge in the sheep is accompanied by a massive and sustained surge of GnRH. The objective of this study was to examine the duration of the…”
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A central negative feedback action of thyroid hormones on thyrotropin-releasing hormone secretion by Dahl, G E, Evans, N P, Thrun, L A, Karsch, F J

“…Two experiments were conducted to test the hypothesis that thyroid hormones exert central negative feedback effects on the secretion of TRH from the…”
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A Critical Period for Thyroid Hormone Action on Seasonal Changes in Reproductive Neuroendocrine Function in the Ewe1 by Thrun, L. A, Dahl, G. E, Evans, N. P, Karsch, F. J

“…Thyroid hormones are obligatory for the annually recurring termination of reproductive activity in a spectrum of seasonal breeders, including sheep. Previous…”
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