Search Results - "Throm, Stacy L"

Pharmacokinetic Properties of Anticancer Agents for the Treatment of Central Nervous System Tumors: Update of the Literature by Jacus, Megan O., Daryani, Vinay M., Harstead, K. Elaine, Patel, Yogesh T., Throm, Stacy L., Stewart, Clinton F.

“…Despite significant improvement in outcomes for patients with hematologic malignancies and solid tumors over the past 10 years, patients with primary or…”
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UGT1A1 Promoter Genotype Correlates With SN-38 Pharmacokinetics, but Not Severe Toxicity in Patients Receiving Low-Dose Irinotecan by STEWART, Clinton F, PANETTA, John C, FURMAN, Wayne L, MCGREGOR, Lisa M, O'SHAUGHNESSY, Melinda A, THROM, Stacy L, FRAGA, Charles H, OWENS, Thandranese, TIEBIN LIU, BILLUPS, Catherine, RODRIGUEZ-GALINDO, Carlos, GAJJAR, Amar

“…To study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and severe toxicity as well as irinotecan disposition in pediatric patients…”
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Low-level GATA2 overexpression promotes myeloid progenitor self-renewal and blocks lymphoid differentiation in mice by Nandakumar, Satish K, Johnson, Kyle, Throm, Stacy L, Pestina, Tamara I, Neale, Geoffrey, Persons, Derek A

“…The transcription factor GATA2 is highly expressed in hematopoietic stem cells and is downregulated during lineage maturation. Gain of function mutations, loss…”
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Population Pharmacokinetics of Bevacizumab in Children with Osteosarcoma: Implications for Dosing by TURNER, David C, NAVID, Fariba, HARSTEAD, K. Elaine, THROM, Stacy L, FREEMAN, Burgess B, STEWART, Clinton F, DAW, Najat C, SHENGHUA MAO, JIANRONG WU, SANTANA, Victor M, NEEL, Michael, RAO, Bhaskar, WILLERT, Jennifer Reikes, LOEB, David M

“…To describe sources of interindividual variability in bevacizumab disposition in pediatric patients and explore associations among bevacizumab pharmacokinetics…”
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PU.1 regulates glutathione peroxidase expression in neutrophils by Throm, Stacy L., Klemsz, Michael J.

“…Based on knockout models, the transcription factor PU.1 has been shown to be important for the maturation of neutrophils. As the list of genes PU.1 directly…”
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Abstract 2708: Development of an individualized 3D transport model of topotecan for a patient-derived orthotopic xenograft model of pediatric neuroblastoma by Shirinifard, Abbas, Thiagarajan, Suresh, Patel, Yogesh T., Davis, Abigail D., Jacus, Megan O., Throm, Stacy L., Roberts, Jessica, Daryani, Vinay, Stewart, Clinton F., Sablauer, András

“…Abstract Resistance to chemotherapeutics and targeted therapies in pediatric solid tumors including neuroblastoma is a common cause of poor clinical outcome…”
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Combination metronomic oral topotecan and pazopanib: a pharmacokinetic study in patients with gynecological cancer by Turner, David C, Tillmanns, Todd D, Harstead, K Elaine, Throm, Stacy L, Stewart, Clinton F

“…Combination metronomic topotecan plus pazopanib is active against preclinical models of gynecological cancer. Both agents are substrates for ATP-binding…”
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Preclinical examination of clofarabine in pediatric ependymoma: intratumoral concentrations insufficient to warrant further study by Patel, Yogesh T., Jacus, Megan O., Boulos, Nidal, Dapper, Jason D., Davis, Abigail D., Vuppala, Pradeep K., Freeman, Burgess B., Mohankumar, Kumarasamypet M., Throm, Stacy L., Gilbertson, Richard J., Stewart, Clinton F.

“…Clofarabine, a deoxyadenosine analog, was an active anticancer drug in our in vitro high-throughput screening against mouse ependymoma neurospheres. To…”
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Determination of crenolanib in human serum and cerebrospinal fluid by liquid chromatography–electrospray ionization-tandem mass spectrometry (LC–ESI-MS/MS) by Roberts, Michael S., Turner, David C., Owens, Thandranese S., Ramachandran, Abhijit, Wetmore, Cynthia, Throm, Stacy L., Stewart, Clinton F.

“…•A novel method for the determination of crenolanib by LC/MS/MS is described.•The method was fully validated in human serum and partially validated in CSF.•The…”
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MDM2 antagonist nutlin-3a reverses mitoxantrone resistance by inhibiting breast cancer resistance protein mediated drug transport by Zhang, Fan, Throm, Stacy L., Murley, Laura L., Miller, Laura A., Steven Zatechka, D., Kiplin Guy, R., Kennedy, Rachel, Stewart, Clinton F.

“…Nutlin-3a increases the intracellular accumulation of anti-cancer drugs (D) that are BCRP substrates and enhances cell death. Breast cancer resistance protein…”
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Magnetic resonance imaging-guided microdialysis cannula implantation in a spontaneous high-grade glioma murine model by Elmeliegy, Mohamed A, Carcaboso, Angel M, L Chow, Lionel M, Zhang, Ziwei M, Calabrese, Christopher, Throm, Stacy L, Wang, Fan, Baker, Suzanne J, Stewart, Clinton F

“…Cerebral microdialysis is used to study anticancer drug penetration in the central nervous system (CNS) and brain tumors in animal models. Genetically…”
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Observational Evaluations of Mice during Cerebral Microdialysis for Pediatric Brain Tumor Research by Jacus, Megan O, Rahija, Richard J., Davis, Abigail D, Throm, Stacy L, Stewart, Clinton F

“…In vivo animal experiments are critical in the process of finding and developing new treatments for children with CNS tumors. Cerebral microdialysis, which…”
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Pharmacokinetic Properties of Anticancer Agents for the Treatment of CNS Tumors: Update of the Literature by Jacus, Megan O., Daryani, Vinay M., Harstead, K. Elaine, Patel, Yogesh T., Throm, Stacy L., Stewart, Clinton F.

“…Despite significant improvement in outcomes for patients with hematological malignancies and solid tumors over the past 10 years, patients with primary or…”
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Abstract 4526: Age dependent disposition of cyclophosphamide (CTX) and metabolites in infants ≤ 1 year old with brain tumors by Daryani, Vinay M., Owens, Thandranese S., Harstead, K. Elaine, Patel, Yogesh T., Turner, David C., Throm, Stacy L., Panetta, John C., Gajjar, Amar, Stewart, Clinton F.

“…Abstract An ongoing trial of risk-adapted therapy for infants and young children < 3 yrs old diagnosed with brain tumors includes IV CTX (NCT00602667). One aim…”
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Abstract 1496: Quantification of tumor blood perfusion of an orthotopic mouse model of neuroblastoma using nonlinear contrast-enhanced ultrasound imaging by Thiagarajan, Suresh, Shirinifard, Abbas, Jacus, Megan O., Davis, Abigail D., Patel, Yogesh T., Throm, Stacy L., Daryani, Vinay, Stewart, Clinton F., Sablauer, András

“…Abstract This study quantifies tumor perfusion in individual tumors to estimate blood flow and blood volume parameters of an individualized tumor compartment…”
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Abstract 4519: Development of a whole body physiologically-based pharmacokinetic (PBPK) model with individualized tumor compartment for topotecan (TPT) in mice bearing neuroblastoma (NB) by Patel, Yogesh T., Jacus, Megan O., Shirinifard, Abbas, Davis, Abigail D., Thiagarajan, Suresh, Throm, Stacy L., Daryani, Vinay M., Sablauer, Andras, Stewart, Clinton F.

“…Abstract Intratumoral pharmacokinetic (PK) and pharmacodynamic (PD) heterogeneity contribute to variability in NB tumor response to chemotherapy and can be…”
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Abstract 4645: Clofarabine, a potent anticancer compound with limited penetration in an orthotopic murine model of ependymoma by Patel, Yogesh T., Jacus, Megan O., Davis, Abigail D., Vuppala, Pradeep, Dapper, Jason D., Freeman, Burgess B., Boulos, Nidal, Throm, Stacy L., Gilbertson, Richard J., Stewart, Clinton F.

“…Abstract Clofarabine, a deoxyadenosine analog, was a potent hit in our in vitro high-throughput screening against murine ependymoma neurospheres. To prioritize…”
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Combination Metronomic Oral Topotecan and Pazopanib: A Pharmacokinetic Study in Cancer Patients with Gynecological Cancer by Turner, David C., Tillmanns, Todd D., Harstead, K. Elaine, Throm, Stacy L., Stewart, Clinton F.

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Developmental pharmacokinetics of topotecan (TPT), a renally excreted drug, in infants and young children with brain tumors by Daryani, Vinay M., Harstead, Katheryn Elaine, Scott, Jeffrey F, Ward, Deborah A, Throm, Stacy L, Bowers, Daniel C., Bendel, Anne Elizabeth, Fisher, Paul Graham, Wright, Karen D., Broniscer, Alberto, Robinson, Giles W., Gajjar, Amar J., Stewart, Clinton F.

“…Abstract only…”
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Abstract 2742: Cerebral microdialysis for simultaneous sampling of crenolanib (PDGFR inhibitor) and erlotinib (EGFR inhibitor) in mouse models of glioma by Elmeliegy, Mohamed, Throm, Stacy L., Wang, Fan, Bai, Feng, Ramachandran, Abhijit, Stewart, Clinton F.

“…Abstract Cerebral microdialysis, a technique used to monitor anticancer drug disposition in the central nervous system (CNS), is commonly used to sample…”
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