Search Results - "Thrall, Karla"

The impact of supportive care on survival in large animal models of total body irradiation by Thrall, Karla D., Mahendra, Saikanth, Lovaglio, Jamie, Jackson, M. Keven

“…Well-characterized animal models that mimic the human response to potentially lethal doses of radiation are necessary in order to assess the efficacy of…”
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A gottingen minipig model of radiation-induced coagulopathy by Thrall, Karla D., Mahendra, Saikanth, Jackson, M. Keven

“…Total body irradiation of the Gottingen minipig results in a characteristic hematopoietic response, including anemia, neutropenia, lymphocytopenia, and…”
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Serum RNA biomarkers for predicting survival in non-human primates following thoracic radiation by May, Jared M., Shankavaram, Uma, Bylicky, Michelle A., Chopra, Sunita, Scott, Kevin, Martello, Shannon, Thrall, Karla, Axtelle, Jim, Menon, Naresh, Coleman, C. Norman, Aryankalayil, Molykutty J.

“…In a mass radiation exposure, the healthcare system may rely on differential expression of miRNA to determine exposure and effectively allocate resources. To…”
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Acute Radiation Effects, the H-ARS in the Non-human Primate: A Review and New Data for the Cynomolgus Macaque with Reference to the Rhesus Macaque by Farese, Ann M., Drouet, Michel, Herodin, Francis, Bertho, Jean-Marc, Thrall, Karla D., Authier, Simon, Doyle-Eisele, Melanie, MacVittie, Thomas J.

“…Medical countermeasure development under the US Food and Drug Administration animal rule requires validated animal models of acute radiation effects. The key…”
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A Comparative Dose-response Relationship Between Sexes for Mortality and Morbidity of Radiation-induced Lung Injury in the Rhesus Macaque by Thrall, Karla D, Mahendra, S, Jackson, M.K, Jackson, William, Farese, Ann M, MacVittie, Thomas J

“…ABSTRACTRadiation-induced lung injury is a characteristic, dose- and time-dependent sequela of potentially lethal, delayed effects of acute radiation exposure…”
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An Interlaboratory Validation of the Radiation Dose Response Relationship (DRR) for H-ARS in the Rhesus Macaque by Thrall, Karla D, Love, Ruschelle, OʼDonnell, Kyle C, Farese, Ann M, Manning, Ronald, MacVittie, Thomas J

“…ABSTRACTThe Medical Countermeasures against Radiological Threats (MCART) consortium has established a dose response relationship for the hematopoietic acute…”
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Plasma Metabolomics in a Nonhuman Primate Model of Abdominal Radiation Exposure by Jun, Se-Ran, Boerma, Marjan, Udaondo, Zulema, Richardson, Sasha, Thrall, Karla D, Miousse, Isabelle R, Seng, John, Pathak, Rupak, Hauer-Jensen, Martin

“…The acute radiation syndrome is defined in large part by radiation injury in the hematopoietic and gastrointestinal (GI) systems. To identify new pathways…”
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Breath Biomarkers of Whole-body Gamma Irradiation in the Göttingen Minipig by Phillips, Michael, Cataneo, Renee N., Chaturvedi, Anirudh, Kaplan, Peter D., Libardoni, Mark, Mundada, Mayur, Patel, Urvish, Thrall, Karla D., Zhang, Xiang

“…ABSTRACTThere is widespread interest in the development of tools to estimate radiation exposures. Exhaled breath provides a novel matrix for assessing…”
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A Dose-Dependent Hematological Evaluation of Whole-Body Gamma-Irradiation in the Göttingen Minipig by Thrall, Karla D, Lovaglio, Jamie, Murphy, Mark K, Cataneo, Renee N, Chaturvedi, Anirudh, Mundada, Mayur, Patel, Urvish, Phillips, Michael

“…There is a great deal of interest in the establishment of a standardized animal model for the acute radiation syndrome to allow development of diagnostic…”
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Physiologically Based Pharmacokinetic Modeling of 1,4-Dioxane in Rats, Mice, and Humans by Sweeney, Lisa M., Thrall, Karla D., Poet, Torka S., Corley, Richard A., Weber, Thomas J., Locey, Betty J., Clarkson, Jacquelyn, Sager, Shawn, Gargas, Michael L.

“…1,4-Dioxane (CAS No. 123-91-1) is used primarily as a solvent or as a solvent stabilizer. It can cause lung, liver, and kidney damage at sufficiently high…”
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Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans by Sweeney, Lisa M., Kirman, Christopher R., Gannon, Shawn A., Thrall, Karla D., Gargas, Michael L., Kinzell, John H.

“…Methyl iodide (MeI) has been proposed as an alternative to methyl bromide as a pre-plant soil fumigant that does not deplete stratospheric ozone. In inhalation…”
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EVALUATION OF CUPRIMINE® AND SYPRINE® FOR DECORPORATION OF RADIOISOTOPES OF CESIUM, COBALT, IRIDIUM AND STRONTIUM by Levitskaia, Tatiana G, Creim, Jeffrey A, Curry, Terry L, Luders, Teresa, Peterson, James M, Thrall, Karla D, Levinson, Barry

“…Cuprimine® and Syprine® are therapeutics approved by the USFDA to treat copper overload in Wilson Disease (a genetic defect in copper transport) by chelation…”
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In vitro glutathione conjugation of methyl iodide in rat, rabbit, and human blood and tissues by Poet, Torka S., Wu, Hong, Corley, Richard A., Thrall, Karla D.

“…Methyl iodide (MeI) is an intermediate in the manufacture of some pesticides and pharmaceuticals, and is under review for US registration as a non-ozone…”
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Biomaterials for the decorporation of (85)Sr in the rat by Levitskaia, Tatiana G, Creim, Jeffrey A, Curry, Terry L, Luders, Teresa, Morris, James E, Peterson, James M, Thrall, Karla D

“…Although four stable isotopes of strontium occur naturally, Sr is produced by nuclear fission and is present in surface soil around the world as a result of…”
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Aminothiol receptors for decorporation of intravenously administered (60)Co in the rat by Levitskaia, Tatiana G, Morris, James E, Creim, Jeffrey A, Woodstock, Angela D, Luders, Teresa, Curry, Terry L, Thrall, Karla D

“…This report provides a comparison of the oral decorporation efficacy of L-glutathione (GSH), L-cysteine (Cys), and a liposomal GSH formulation (ReadiSorb)…”
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A real-time methodology to evaluate the nasal absorption of volatile compounds in anesthetized animals by Thrall, Karla D., Woodstock, Angela D., Soelberg, Jolen J., Gargas, Michael L., Kinzell, John H., Corley, Richard A.

“…Nasal dosimetry models that combine computational fluid dynamics and physiologically based pharmacokinetic modeling incorporate information on species-specific…”
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Studies supporting the development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide: pharmacokinetics of sodium iodide (NaI) in pregnant rabbits by Thrall, Karla D., Sasser, Lyle B., Creim, Jeff A., Gargas, Michael L., Kinzell, John H., Corley, Richard A.

“…Methyl iodide (MeI) is a water soluble monohalomethane that is metabolized in vivo to release iodide (I−). A physiologically based pharmacokinetic (PBPK) model…”
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IACUC evaluation and external scientific review. IACUC overstepping its bounds by Poston, Ted M, Thrall, Karla D, Penner, Jocelyn D

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Response to Protocol Review: IACUC overstepping its bounds by Poston, Ted M, Thrall, Karla D, Penner, Jocelyn D

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Evaluation of the Dermal Bioavailability of Aqueous Xylene in F344 Rats and Human Volunteers by Thrall, Karla, Woodstock, Angela

“…Xylene is a clear, colorless liquid used as a solvent in the printing, rubber, and leather industries and is commonly found in paint thinners, paints,…”
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