Search Results - "Thowfeik, Fathima Shazna"

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake by Beg, Muheeb, Abdullah, Nazish, Thowfeik, Fathima Shazna, Altorki, Nasser K, McGraw, Timothy E

“…Insulin, downstream of Akt activation, promotes glucose uptake into fat and muscle cells to lower postprandial blood glucose, an enforced change in cellular…”
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Ruthenium dihydroxybipyridine complexes are tumor activated prodrugs due to low pH and blue light induced ligand release by Hufziger, Kyle T., Thowfeik, Fathima Shazna, Charboneau, David J., Nieto, Ismael, Dougherty, William G., Kassel, W. Scott, Dudley, Timothy J., Merino, Edward J., Papish, Elizabeth T., Paul, Jared J.

“…Ruthenium drugs are potent anti-cancer agents, but inducing drug selectivity and enhancing their modest activity remain challenging. Slow Ru ligand loss limits…”
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Investigation of fluorinated and bifunctionalized 3-phenylchroman-4-one (isoflavanone) aromatase inhibitors by Amato, Erica, Bankemper, Tony, Kidney, Rebecca, Do, Thuy, Onate, Alma, Thowfeik, Fathima Shazna, Merino, Edward J., Paula, Stefan, Ma, Lili

“…Fluorinated isoflavanones and bifunctionalized isoflavanones were synthesized through a one-step gold(I)-catalyzed annulation reaction. These compounds were…”
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Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability by AbdulSalam, Safnas F, Thowfeik, Fathima Shazna, Merino, Edward J

“…Although the terms “excessive reactive oxygen species (ROS)” and “oxidative stress” are widely used, the implications of oxidative stress are often…”
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Ruthenium Complexes are pH-Activated Metallo Prodrugs (pHAMPs) with Light-Triggered Selective Toxicity Toward Cancer Cells by Qu, Fengrui, Park, Seungjo, Martinez, Kristina, Gray, Jessica L, Thowfeik, Fathima Shazna, Lundeen, John A, Kuhn, Ashley E, Charboneau, David J, Gerlach, Deidra L, Lockart, Molly M, Law, James A, Jernigan, Katherine L, Chambers, Nicole, Zeller, Matthias, Piro, Nicholas A, Kassel, W. Scott, Schmehl, Russell H, Paul, Jared J, Merino, Edward J, Kim, Yonghyun, Papish, Elizabeth T

“…Metallo prodrugs that take advantage of the inherent acidity surrounding cancer cells have yet to be developed. We report a new class of pH-activated metallo…”
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A ROS-Activatable Agent Elicits Homologous Recombination DNA Repair and Synergizes with Pathway Compounds by Thowfeik, Fathima Shazna, AbdulSalam, Safnas F., Wunderlich, Mark, Wyder, Michael, Greis, Kenneth D., Kadekaro, Ana L., Mulloy, James C., Merino, Edward J.

“…We designed ROS‐activated cytotoxic agents (RACs) that are active against AML cancer cells. In this study, the mechanism of action and synergistic effects…”
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Novel ROS-activated agents utilize a tethered amine to selectively target acute myeloid leukemia by Bell-Horwath, Tiffany R., Vadukoot, Anish K., Thowfeik, Fathima Shazna, Li, Guorui, Wunderlich, Mark, Mulloy, James C., Merino, Edward J.

“…This study explores the possible use of reactive oxygen-activated DNA modifying agents against acute myeloid leukemia (AML). A key amine on the lead agent was…”
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Targeting a common enemy: Toxic cellular mechanism of novel anti-cancer agents that alter DNA and transcription by Thowfeik, Fathima Shazna

“…Cancer is a major public health problem in the worldwide and second leading cause of death in the United States. The major problem in treatment of cancer is…”
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