Search Results - "Thorson, S"

A comprehensive review of glycosylated bacterial natural products by Elshahawi, Sherif I, Shaaban, Khaled A, Kharel, Madan K, Thorson, Jon S

“…A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites reported in the scientific literature up through early 2013 is…”
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Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications by Jalali, Elnaz, Thorson, Jon S

“…Transferases have emerged as among the best catalysts for enzyme-mediated bioorthogonal functional group installation to advance innovative in vitro,…”
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Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules by Gantt, Richard W, Peltier-Pain, Pauline, Thorson, Jon S

“…Glyco (randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of…”
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AdoMet analog synthesis and utilization: current state of the art by Huber, Tyler D, Johnson, Brooke R, Zhang, Jianjun, Thorson, Jon S

“…Graphical abstract…”
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Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation by Chang, Aram, Singh, Shanteri, Phillips, George N, Thorson, Jon S

“…Highlights ► Glycosyltransferases (GTs) are an important class of enzyme as both drug targets and synthetic catalysts. ► Two predominant GT folds (GT-A and…”
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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution by Thorson, Jon S, Williams, Gavin J, Zhang, Changsheng

“…Natural products, many of which are decorated with essential sugar residues, continue to serve as a key platform for drug development. Adding or changing…”
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Bioprospecting of desert actinobacteria with special emphases on griseoviridin, mitomycin C and a new bacterial metabolite producing Streptomyces sp. PU-KB10-4 by Saleem, Maira, Hassan, Ashba, Li, Feina, Lu, Qinpei, Ponomareva, Larissa V, Parkin, Sean, Sun, Chenghang, Thorson, Jon S, Shaaban, Khaled A, Sajid, Imran

“…Bioprospecting of actinobacteria isolated from Kubuqi desert, China for antibacterial, antifungal and cytotoxic metabolites production and their structure…”
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Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis by Gantt, Richard W., Peltier-Pain, Pauline, Singh, Shanteri, Zhou, Maoquan, Thorson, Jon S.

“…We described the integration of the general reversibility of glycosyltransferase-catalyzed reactions, artificial glycosyl donors, and a high throughput…”
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Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions by Gantt, Richard W, Peltier-Pain, Pauline, Cournoyer, William J, Thorson, Jon S

“…A systematic analysis of possible substrates for reverse glycosyltransferase reactions reveals thermodynamically favored pathways to the traditional…”
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Structure, activity, synthesis and biosynthesis of aryl-C-glycosides by Bililign, Tsion, Griffith, Byron R, Thorson, Jon S

“…The focus of this review is to highlight the structure, bioactivity and biosynthesis of naturally occurring aryl-C-glycosides. General synthetic methods and…”
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Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471 by Cui, Zheng, Wang, Xiachang, Koppermann, Stefan, Thorson, Jon S, Ducho, Christian, Van Lanen, Steven G

“…Muraymycins are nucleoside antibiotics isolated from Streptomyces sp. NRRL 30471 and several mutant strains thereof that were generated by random, chemical…”
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Spore forming Actinobacterial diversity of Cholistan Desert Pakistan: Polyphasic taxonomy, antimicrobial potential and chemical profiling by Fatima, Adeela, Aftab, Usman, Shaaban, Khaled A, Thorson, Jon S, Sajid, Imran

“…Actinobacteria are famous for the production of unique secondary metabolites that help in controlling the continuously emerging drug resistance all over the…”
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Structure and specificity of a permissive bacterial C-prenyltransferase by Elshahawi, Sherif I, Cao, Hongnan, Shaaban, Khaled A, Ponomareva, Larissa V, Subramanian, Thangaiah, Farman, Mark L, Spielmann, H Peter, Phillips, George N, Thorson, Jon S, Singh, Shanteri

“…Discovery and characterization of an unusually permissive C-prenyltransferase provides a biocatalytic route for generating novel prenylated compounds,…”
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Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase by Gantt, Richard W, Goff, Randal D, Williams, Gavin J, Thorson, Jon S

“…A sweet library: Two variants (wild‐type (WT) and a triple mutant) of glycosyltransferase (GT) OleD have been shown to catalyze glycosylation of over 70…”
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Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects by Ye, Qing, Zhang, Yinan, Cao, Yanan, Wang, Xiachang, Guo, Yubin, Chen, Jing, Horn, Jamie, Ponomareva, Larissa V, Chaiswing, Luksana, Shaaban, Khaled A, Wei, Qiou, Anderson, Bradley D, St Clair, Daret K, Zhu, Haining, Leggas, Markos, Thorson, Jon S, She, Qing-Bai

“…Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor…”
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Antitumor Antibiotics:  Bleomycin, Enediynes, and Mitomycin by Galm, Ute, Hager, Martin H, Van Lanen, Steven G, Ju, Jianhua, Thorson, Jon S, Shen, Ben

“…Galm et. al discuss the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and…”
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Antibacterial Activity of Endophytic Actinomycetes Isolated from the Medicinal Plant Vochysia divergens (Pantanal, Brazil) by Gos, Francielly M W R, Savi, Daiani C, Shaaban, Khaled A, Thorson, Jon S, Aluizio, Rodrigo, Possiede, Yvelise M, Rohr, Jürgen, Glienke, Chirlei

“…Endophytic actinomycetes from medicinal plants produce a wide diversity of secondary metabolites (SM). However, to date, the knowledge about endophytes from…”
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Genome sequencing of an extended series of NDM-producing Klebsiella pneumoniae isolates from neonatal infections in a Nepali hospital characterizes the extent of community- versus hospital-associated transmission in an endemic setting by Stoesser, N, Giess, A, Batty, E M, Sheppard, A E, Walker, A S, Wilson, D J, Didelot, X, Bashir, A, Sebra, R, Kasarskis, A, Sthapit, B, Shakya, M, Kelly, D, Pollard, A J, Peto, T E A, Crook, D W, Donnelly, P, Thorson, S, Amatya, P, Joshi, S

“…NDM-producing Klebsiella pneumoniae strains represent major clinical and infection control challenges, particularly in resource-limited settings with high…”
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Endophytes of Brazilian Medicinal Plants With Activity Against Phytopathogens by Iantas, Jucélia, Savi, Daiani Cristina, Schibelbein, Renata da Silva, Noriler, Sandriele Aparecida, Assad, Beatriz Marques, Dilarri, Guilherme, Ferreira, Henrique, Rohr, Jürgen, Thorson, Jon S., Shaaban, Khaled A., Glienke, Chirlei

“…Plant diseases caused by phytopathogens are responsible for significant crop losses worldwide. Resistance induction and biological control have been exploited…”
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Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions by Zhang, Changsheng, Griffith, Byron R, Fu, Qiang, Albermann, Christoph, Fu, Xun, Lee, In-Kyoung, Li, Lingjun, Thorson, Jon S

“…Glycosyltransferases (GTs), an essential class of ubiquitous enzymes, are generally perceived as unidirectional catalysts. In contrast, we report that four…”
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