Search Results - "Thorson, Jon"

A comprehensive review of glycosylated bacterial natural products by Elshahawi, Sherif I, Shaaban, Khaled A, Kharel, Madan K, Thorson, Jon S

“…A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites reported in the scientific literature up through early 2013 is…”
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Enzyme-mediated bioorthogonal technologies: catalysts, chemoselective reactions and recent methyltransferase applications by Jalali, Elnaz, Thorson, Jon S

“…Transferases have emerged as among the best catalysts for enzyme-mediated bioorthogonal functional group installation to advance innovative in vitro,…”
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Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules by Gantt, Richard W, Peltier-Pain, Pauline, Thorson, Jon S

“…Glyco (randomization/diversification) is a term that encompasses strategies to diversify a core drug scaffold via enzymatic glycosylation to provide sets of…”
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AdoMet analog synthesis and utilization: current state of the art by Huber, Tyler D, Johnson, Brooke R, Zhang, Jianjun, Thorson, Jon S

“…Graphical abstract…”
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Bioprospecting of desert actinobacteria with special emphases on griseoviridin, mitomycin C and a new bacterial metabolite producing Streptomyces sp. PU-KB10-4 by Saleem, Maira, Hassan, Ashba, Li, Feina, Lu, Qinpei, Ponomareva, Larissa V, Parkin, Sean, Sun, Chenghang, Thorson, Jon S, Shaaban, Khaled A, Sajid, Imran

“…Bioprospecting of actinobacteria isolated from Kubuqi desert, China for antibacterial, antifungal and cytotoxic metabolites production and their structure…”
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Hydrocarbon-induced bleaching and copper mineralization in the Wingate Sandstone, Paradox Valley, Colorado; two episodes of fluid migration during the evolution of the Paradox Basin by MacIntyre, Timothy J, Hitzman, Murray W, Thorson, Jon P

“…Fluid generation and movement are key components of basin evolution, with important implications for hydrocarbon and mineral exploration. Unlike…”
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Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation by Chang, Aram, Singh, Shanteri, Phillips, George N, Thorson, Jon S

“…Highlights ► Glycosyltransferases (GTs) are an important class of enzyme as both drug targets and synthetic catalysts. ► Two predominant GT folds (GT-A and…”
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Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution by Thorson, Jon S, Williams, Gavin J, Zhang, Changsheng

“…Natural products, many of which are decorated with essential sugar residues, continue to serve as a key platform for drug development. Adding or changing…”
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Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis by Gantt, Richard W., Peltier-Pain, Pauline, Singh, Shanteri, Zhou, Maoquan, Thorson, Jon S.

“…We described the integration of the general reversibility of glycosyltransferase-catalyzed reactions, artificial glycosyl donors, and a high throughput…”
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Probing the Aglycon Promiscuity of an Engineered Glycosyltransferase by Gantt, Richard W, Goff, Randal D, Williams, Gavin J, Thorson, Jon S

“…A sweet library: Two variants (wild‐type (WT) and a triple mutant) of glycosyltransferase (GT) OleD have been shown to catalyze glycosylation of over 70…”
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Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactions by Gantt, Richard W, Peltier-Pain, Pauline, Cournoyer, William J, Thorson, Jon S

“…A systematic analysis of possible substrates for reverse glycosyltransferase reactions reveals thermodynamically favored pathways to the traditional…”
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Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471 by Cui, Zheng, Wang, Xiachang, Koppermann, Stefan, Thorson, Jon S, Ducho, Christian, Van Lanen, Steven G

“…Muraymycins are nucleoside antibiotics isolated from Streptomyces sp. NRRL 30471 and several mutant strains thereof that were generated by random, chemical…”
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Spore forming Actinobacterial diversity of Cholistan Desert Pakistan: Polyphasic taxonomy, antimicrobial potential and chemical profiling by Fatima, Adeela, Aftab, Usman, Shaaban, Khaled A, Thorson, Jon S, Sajid, Imran

“…Actinobacteria are famous for the production of unique secondary metabolites that help in controlling the continuously emerging drug resistance all over the…”
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Structure and specificity of a permissive bacterial C-prenyltransferase by Elshahawi, Sherif I, Cao, Hongnan, Shaaban, Khaled A, Ponomareva, Larissa V, Subramanian, Thangaiah, Farman, Mark L, Spielmann, H Peter, Phillips, George N, Thorson, Jon S, Singh, Shanteri

“…Discovery and characterization of an unusually permissive C-prenyltransferase provides a biocatalytic route for generating novel prenylated compounds,…”
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Assessing the Regioselectivity of OleD-Catalyzed Glycosylation with a Diverse Set of Acceptors by Zhou, Maoquan, Hamza, Adel, Zhan, Chang-Guo, Thorson, Jon S

“…To explore the acceptor regioselectivity of OleD-catalyzed glucosylation, the products of OleD-catalyzed reactions with six structurally diverse acceptors…”
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A discrete intermediate for the biosynthesis of both the enediyne core and the anthraquinone moiety of enediyne natural products by Bhardwaj, Minakshi, Cui, Zheng, Daniel Hankore, Erome, Moonschi, Faruk H, Saghaeiannejad Esfahani, Hoda, Kalkreuter, Edward, Gui, Chun, Yang, Dong, Phillips, Jr, George N, Thorson, Jon S, Shen, Ben, Van Lanen, Steven G

“…The enediynes are structurally characterized by a 1,5-diyne-3-ene motif within a 9- or 10-membered enediyne core. The anthraquinone-fused enediynes (AFEs) are…”
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Facile Chemoenzymatic Strategies for the Synthesis and Utilization of S-Adenosyl-L-Methionine Analogues by Singh, Shanteri, Zhang, Jianjun, Huber, Tyler D., Sunkara, Manjula, Hurley, Katherine, Goff, Randal D., Wang, Guojun, Zhang, Wen, Liu, Chunming, Rohr, Jürgen, Van Lanen, Steven G., Morris, Andrew J., Thorson, Jon S.

“…A chemoenzymatic platform for the synthesis of S‐adenosyl‐L‐methionine (SAM) analogues compatible with downstream SAM‐utilizing enzymes is reported. Forty‐four…”
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Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects by Ye, Qing, Zhang, Yinan, Cao, Yanan, Wang, Xiachang, Guo, Yubin, Chen, Jing, Horn, Jamie, Ponomareva, Larissa V, Chaiswing, Luksana, Shaaban, Khaled A, Wei, Qiou, Anderson, Bradley D, St Clair, Daret K, Zhu, Haining, Leggas, Markos, Thorson, Jon S, She, Qing-Bai

“…Peroxiredoxin 1 (Prx1) and glutaredoxin 3 (Grx3) are two major antioxidant proteins that play a critical role in maintaining redox homeostasis for tumor…”
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Pyridoxal-5′-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis by Cui, Zheng, Overbay, Jonathan, Wang, Xiachang, Liu, Xiaodong, Zhang, Yinan, Bhardwaj, Minakshi, Lemke, Anke, Wiegmann, Daniel, Niro, Giuliana, Thorson, Jon S., Ducho, Christian, Van Lanen, Steven G.

“…Several nucleoside antibiotics are structurally characterized by a 5″-amino-5″-deoxyribose (ADR) appended via a glycosidic bond to a high-carbon sugar…”
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Antitumor Antibiotics:  Bleomycin, Enediynes, and Mitomycin by Galm, Ute, Hager, Martin H, Van Lanen, Steven G, Ju, Jianhua, Thorson, Jon S, Shen, Ben

“…Galm et. al discuss the current level of understanding and emerging trends relevant to the DNA-damaging metabolite families of the bleomycins, 9- and…”
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