Search Results - "Thorson, J. S."

Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia by Rivas, J. R., Liu, Y., Alhakeem, S. S., Eckenrode, J. M., Marti, F., Collard, J. P., Zhang, Y., Shaaban, K. A., Muthusamy, N., Hildebrandt, G. C., Fleischman, R. A., Chen, L., Thorson, J. S., Leggas, M., Bondada, S.

“…T-cell dysfunction is a hallmark of B-cell Chronic Lymphocytic Leukemia (CLL), where CLL cells downregulate T-cell responses through regulatory molecules…”
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Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA by THORSON, J. S, LO, S. F, PLOUX, O, XUEMEI HE, HUNG-WEN LIU

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cloning, sequencing, and overexpression in Escherichia coli of the alpha-D-glucose-1-phosphate cytidylyltransferase gene isolated from Yersinia pseudotuberculosis by Thorson, J.S, Kelly, T.M, Liu, H.W

“…A clone of Yersinia pseudotuberculosis DNA carrying the ascA gene was constructed, and the corresponding protein was successfully overexpressed in Escherichia…”
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Antibiotic optimization via in vitro glycorandomization by Thorson, Jon S, Fu, Xun, Albermann, Christoph, Jiang, Jiqing, Liao, Jianchun, Zhang, Changsheng

“…In nature, the attachment of sugars to small molecules is often used to mediate targeting, mechanism of action and/or pharmacology. As an alternative to…”
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A genomics-guided approach for discovering and expressing cryptic metabolic pathways by Farnet, Chris M, Zazopoulos, Emmanuel, Huang, Kexue, Staffa, Alfredo, Liu, Wen, Bachmann, Brian O, Nonaka, Koichi, Ahlert, Joachim, Thorson, Jon S, Shen, Ben

“…Genome analysis of actinomycetes has revealed the presence of numerous cryptic gene clusters encoding putative natural products. These loci remain dormant…”
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The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS by Ahlert, Joachim, Shepard, Erica, Lomovskaya, Natalia, Zazopoulos, Emmanuel, Staffa, Alfredo, Bachmann, Brian O., Huang, Kexue, Fonstein, Leonid, Czisny, Anne, Whitwam, Ross E., Farnet, Chris M., Thorson, Jon S.

“…The enediynes exemplify nature's ingenuity. We have cloned and characterized the biosynthetic locus coding for perhaps the most notorious member of the…”
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Mechanistic studies of the biosynthesis of 3,6-dideoxyhexoses in Yersinia pseudotuberculosis. Purification and stereochemical analysis of CDP-D-glucose oxidoreductase by YUAN YU, RUSSELL, R. N, THORSON, J. S, LI-DA LIU, HUNG-WEN LIU

“…An NAD(+)-dependent CDP-D-glucose oxidoreductase which catalyzes the first step of the biosynthesis of CDP-ascarylose (CDP-3,6-dideoxy-L-arabino-hexose),…”
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Rapid PCR Amplification of Minimal Enediyne Polyketide Synthase Cassettes Leads to a Predictive Familial Classification Model by Liu, Wen, Ahlert, Joachim, Gao, Qunjie, Wendt-Pienkowski, Evelyn, Shen, Ben, Thorson, Jon S.

“…A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of this methodology to clone…”
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Biosynthesis of 3,6-dideoxyhexoses: new mechanistic reflections upon 2,6-dideoxy, 4,6-dideoxy, and amino sugar construction by Thorson, Jon S, Lo, Stanley F, Liu, Hung Wen, Hutchinson, C. Richard

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Analysis of the Role of the Active Site Tyrosine in Human Glutathione Transferase A1-1 by Unnatural Amino Acid Mutagenesis by Thorson, Jon S, Shin, Injae, Chapman, Eli, Stenberg, Gun, Mannervik, Bengt, Schultz, Peter G

“…A major detoxification pathway used by aerobic organisms involves the enzymatic conjugation of the tripeptide glutathione (GSH) to the electrophilic center of…”
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Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria by HUNG-WEN LIU, THORSON, J. S

“…Science has long recognized the ubiquitously occurring deoxysugars as a novel and important class of carbohydrate, by virtue of the variety of potent and…”
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Resistance to Enediyne Antitumor Antibiotics by CalC Self-Sacrifice by Biggins, John B., Onwueme, Kenolisa C., Thorson, Jon S.

“…Antibiotic self-resistance mechanisms, which include drug elimination, drug modification, target modification, and drug sequestration, contribute substantially…”
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Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research by Thorson, J S, Sievers, E L, Ahlert, J, Shepard, E, Whitwam, R E, Onwueme, K C, Ruppen, M

“…The enediyne antitumor antibiotics are appreciated for their novel molecular architecture, their remarkable biological activity and their fascinating mode of…”
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A Continuous Assay for DNA Cleavage: The Application of "Break Lights" to Enediynes, Iron-Dependent Agents, and Nucleases by Biggins, J B, Prudent, J R, Marshall, D J, Ruppen, M, Thorson, J S

“…Although extensive effort has been applied toward understanding the mechanism by which enediynes cleave DNA, a continuous assay for this phenomenon is still…”
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Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization by Thorson, Jon S, Nikolov, Dimitar B, Barton, William A, Lesniak, Jacob, Biggins, John B, Jeffrey, Philip D, Jiang, Jiqing, Rajashankar, K. R

“…Metabolite glycosylation is affected by three classes of enzymes: nucleotidylyltransferases, which activate sugars as nucleotide diphospho-derivatives,…”
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Expanding Pyrimidine Diphosphosugar Libraries Via Structure-Based Nucleotidylyltransferase Engineering by Barton, William A., Biggins, John B., Jiang, Jiqing, Thorson, Jon S., Nikolov, Dimitar B.

“…In vitro "glycorandomization" is a chemoenzymatic approach for generating diverse libraries of glycosylated biomolecules based on natural product scaffolds…”
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Molecular basis of 3,6-dideoxyhexose biosynthesis: elucidation of CDP-ascarylose biosynthetic genes and their relationship to other 3,6-dideoxyhexose pathways by Thorson, Jon S, Lo, Stanley F, Liu, Hung Wen

“…Among the vast number of monosaccharides identified as components of O-specific polysaccharides, the 3,6-dideoxyhexoses have attracted particular attention due…”
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Biosynthesis of Indolocarbazoles in a Heterologous E. coli Host by Hyun, Chang-Gu, Bililign, Tsion, Liao, Jianchun, Thorson, Jon S

“…The antitumor antibiotic rebeccamycin (1), produced by the bacterium Saccharothrix aerocolonigenes, is a prototype of a class of complex natural products…”
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Studies of complex enzymatic pyridine nucleotide-dependent transformations : structure and cofactor binding correlation in CDP-D-glucose oxidoreductase by THORSON, J. S, OH, E, HUNG-WEN LIU

“…In studying the biosynthesis of 3,6-dideoxyhexoses, we have recently purified a CDP-D-glucose oxidoreductase (E sub(od)) from a strain of Yersinia…”
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Mutational Analysis of Backbone Hydrogen Bonds in Staphylococcal Nuclease by Chapman, Eli, Thorson, Jon S, Schultz, Peter G

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