Search Results - "Thorpe, Stephen"

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells by Heo, Su-Jin, Thorpe, Stephen D., Driscoll, Tristan P., Duncan, Randall L., Lee, David A., Mauck, Robert L.

“…Mechanical cues direct the lineage commitment of mesenchymal stem cells (MSCs). In this study, we identified the operative molecular mechanisms through which…”
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GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment by Cortes, Ernesto, Sarper, Muge, Robinson, Benjamin, Lachowski, Dariusz, Chronopoulos, Antonios, Thorpe, Stephen D, Lee, David A, del Río Hernández, Armando E

“…The mechanical properties of the tumor microenvironment are emerging as attractive targets for the development of therapies. Tamoxifen, an agonist of the G…”
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Modulating gradients in regulatory signals within mesenchymal stem cell seeded hydrogels: a novel strategy to engineer zonal articular cartilage by Thorpe, Stephen D, Nagel, Thomas, Carroll, Simon F, Kelly, Daniel J

“…Engineering organs and tissues with the spatial composition and organisation of their native equivalents remains a major challenge. One approach to engineer…”
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Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models by Thompson, Clare L, Fu, Su, Knight, Martin M, Thorpe, Stephen D

“…Organ-on-chip (OOC) systems recapitulate key biological processes and responses exhibited by cells, tissues, and organs . Accordingly, these models of both…”
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Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway by Chronopoulos, Antonios, Thorpe, Stephen D., Cortes, Ernesto, Lachowski, Dariusz, Rice, Alistair J., Mykuliak, Vasyl V., Róg, Tomasz, Lee, David A., Hytönen, Vesa P., del Río Hernández, Armando E.

“…Extensive research over the past decades has identified integrins to be the primary transmembrane receptors that enable cells to respond to external mechanical…”
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Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor by Cortes, Ernesto, Lachowski, Dariusz, Rice, Alistair, Thorpe, Stephen D., Robinson, Benjamin, Yeldag, Gulcen, Lee, David A., Ghemtio, Leo, Rombouts, Krista, del Río Hernández, Armando E.

“…Tamoxifen has been used for many years to target estrogen receptor signalling in breast cancer cells. Tamoxifen is also an agonist of the G protein-coupled…”
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Is photography-based taxonomy really inadequate, unnecessary, and potentially harmful for biological sciences? A reply to Ceríaco et al. (2016) by Thorpe, Stephen E

“…An opinion piece was recently published in this journal which, remarkably, is less than one page in length, but has 493 authors (signatories) and has gained…”
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Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity by Heo, Su-Jin, Driscoll, Tristan P, Thorpe, Stephen D, Nerurkar, Nandan L, Baker, Brendon M, Yang, Michael T, Chen, Christopher S, Lee, David A, Mauck, Robert L

“…Mesenchymal stem cell (MSC) differentiation is mediated by soluble and physical cues. In this study, we investigated differentiation-induced transformations in…”
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Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration by Sliogeryte, Kristina, Thorpe, Stephen D, Wang, Zhao, Thompson, Clare L, Gavara, Nuria, Knight, Martin M

“…Abstract The actin cytoskeleton forms a dynamic structure involved in many fundamental cellular processes including the control of cell morphology, migration…”
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Dynamic regulation of nuclear architecture and mechanics-a rheostatic role for the nucleus in tailoring cellular mechanosensitivity by Thorpe, Stephen D., Lee, David A.

“…Nuclear architecture, a function of both chromatin and nucleoskeleton structure, is known to change with stem cell differentiation and differs between various…”
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Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival by Cortes, Ernesto, Lachowski, Dariusz, Robinson, Benjamin, Sarper, Muge, Teppo, Jaakko S, Thorpe, Stephen D, Lieberthal, Tyler J, Iwamoto, Kazunari, Lee, David A, Okada‐Hatakeyama, Mariko, Varjosalo, Markku T, del Río Hernández, Armando E

“…The tumor microenvironment is fundamental to cancer progression, and the influence of its mechanical properties is increasingly being appreciated. Tamoxifen…”
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Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF‐1r Onto the Primary Cilium Associated With Cilia Elongation by Dalbay, Melis T., Thorpe, Stephen D., Connelly, John T., Chapple, J. Paul, Knight, Martin M.

“…Primary cilia are single non‐motile organelles that provide a highly regulated compartment into which specific proteins are trafficked as a critical part of…”
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Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria by Thorpe, Stephen D., Gambassi, Silvia, Thompson, Clare L., Chandrakumar, Charmilie, Santucci, Annalisa, Knight, Martin M.

“…Alkaptonuria (AKU) is a rare inherited disease resulting from a deficiency of the enzyme homogentisate 1,2‐dioxygenase which leads to the accumulation of…”
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Machine learning and artificial intelligence: Enabling the clinical translation of atomic force microscopy-based biomarkers for cancer diagnosis by O’Dowling, Aidan T., Rodriguez, Brian J., Gallagher, Tom K., Thorpe, Stephen D.

“…The influence of biomechanics on cell function has become increasingly defined over recent years. Biomechanical changes are known to affect oncogenesis;…”
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Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression by Meyer, Eric G, Buckley, Conor T, Thorpe, Stephen D, Kelly, Daniel J

“…Abstract During fracture healing and microfracture treatment of cartilage defects mesenchymal stem cells (MSCs) infiltrate the wound site, proliferate…”
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Response of Bone Marrow-Derived Mesenchymal Stem Cells to Dynamic Compression Following TGF-β3 Induced Chondrogenic Differentiation by Thorpe, Stephen D, Buckley, Conor T, Vinardell, Tatiana, O'Brien, Fergal J, Campbell, Veronica A, Kelly, Daniel J

“…The objective of this study was to investigate the hypothesis that the application of dynamic compression following transforming growth factor-β3 (TGF-β3)…”
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Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics by Sliogeryte, Kristina, Thorpe, Stephen D., Lee, David A., Botto, Lorenzo, Knight, Martin M.

“…This study examines how differentiation of human mesenchymal stem cells regulates the interaction between the cell membrane and the actin cortex controlling…”
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An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation by Harris, Christopher, Thorpe, Stephen D., Rushwan, Sara, Wang, Wei, Thompson, Clare L., Peacock, Janet L., Knight, Martin M., Gooptu, Bibek, Greenough, Anne

“…Children randomised in the neonatal period to high frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) in the United Kingdom…”
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European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate by Thorpe, Stephen D, Buckley, Conor T, Steward, Andrew J, Kelly, Daniel J

“…Abstract The aim of this study was to explore how cell–matrix interactions and extrinsic mechanical signals interact to determine stem cell fate in response to…”
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Highlight on the dynamic organization of the nucleus by Thorpe, Stephen D, Charpentier, Myriam

“…The last decade has seen rapid advances in our understanding of the proteins of the nuclear envelope, which have multiple roles including positioning the…”
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