Search Results - "Thornton, Sherry"

Thrombin promotes diet-induced obesity through fibrin-driven inflammation by Kopec, Anna K, Abrahams, Sara R, Thornton, Sherry, Palumbo, Joseph S, Mullins, Eric S, Divanovic, Senad, Weiler, Hartmut, Owens, 3rd, A Phillip, Mackman, Nigel, Goss, Ashley, van Ryn, Joanne, Luyendyk, James P, Flick, Matthew J

“…Obesity promotes a chronic inflammatory and hypercoagulable state that drives cardiovascular disease, type 2 diabetes, fatty liver disease, and several…”
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Urine S100 proteins as potential biomarkers of lupus nephritis activity by Turnier, Jessica L, Fall, Ndate, Thornton, Sherry, Witte, David, Bennett, Michael R, Appenzeller, Simone, Klein-Gitelman, Marisa S, Grom, Alexei A, Brunner, Hermine I

“…Improved, noninvasive biomarkers are needed to accurately detect lupus nephritis (LN) activity. The purpose of this study was to evaluate five S100 proteins…”
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Neutrophils From Children With Systemic Juvenile Idiopathic Arthritis Exhibit Persistent Proinflammatory Activation Despite Long-Standing Clinically Inactive Disease by Brown, Rachel A, Henderlight, Maggie, Do, Thuy, Yasin, Shima, Grom, Alexei A, DeLay, Monica, Thornton, Sherry, Schulert, Grant S

“…Systemic juvenile idiopathic arthritis (SJIA) is a chronic childhood arthropathy with features of autoinflammation. Early inflammatory SJIA is associated with…”
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Correction: S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis by Brunner, Hermine I, Schulert, Grant S, Sproles, Alyssa, Thornton, Sherry, Cornejo, Gabriel Vega, Antón, Jordi, Cuttica, Ruben, Henrickson, Michael, Foeldvari, Ivan, Kingsbury, Daniel J, Askelson, Margarita, Liu, Jinqi, Mukherjee, Sumanta, Wong, Robert L, Lovell, Daniel J, Martini, Alberto, Ruperto, Nicolino, Grom, Alexei A

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S100 proteins as potential predictive biomarkers of abatacept response in polyarticular juvenile idiopathic arthritis by Brunner, Hermine I, Schulert, Grant S, Sproles, Alyssa, Thornton, Sherry, Cornejo, Gabriel Vega, Antón, Jordi, Cuttica, Ruben, Henrickson, Michael, Foeldvari, Ivan, Kingsbury, Daniel J, Askelson, Margarita, Liu, Jinqi, Mukherjee, Sumanta, Wong, Robert L, Lovell, Daniel J, Martini, Alberto, Ruperto, Nicolino, Grom, Alexei A

“…Juvenile idiopathic arthritis (JIA) comprises a heterogeneous group of conditions that can cause marked disability and diminished quality of life. Data on…”
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Head-to-head comparison of protocol modifications for the generation of collagen-induced arthritis in a specific-pathogen free facility using DBA/1 mice by Thornton, Sherry, Strait, Richard T

“…Collagen-induced arthritis (CIA) is a widely used mouse model for studying inflammatory arthritis (IA). However, CIA induction protocols differ between…”
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Cγ1 Deficiency Exacerbates Collagen‐Induced Arthritis by Strait, Richard T., Thornton, Sherry, Finkelman, Fred D.

“…Objective IgG antibodies protect by aggregating pathogens and activating complement and stimulatory Fcγ receptors (FcγR). Although IgG1 accounts for a large…”
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Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion by Raghu, Harini, Cruz, Carolina, Rewerts, Cheryl L., Frederick, Malinda D., Thornton, Sherry, Mullins, Eric S., Schoenecker, Jonathan G., Degen, Jay L., Flick, Matthew J.

“…Rheumatoid arthritis is a chronic inflammatory disease characterized by synovial hyperplasia, inflammatory cell infiltration, irreversible cartilage and bone…”
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Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study by Angeles-Han, Sheila T., Yeh, Steven, Patel, Purnima, Duong, Duc, Jenkins, Kirsten, Rouster-Stevens, Kelly A., Altaye, Mekibib, Fall, Ndate, Thornton, Sherry, Prahalad, Sampath, Holland, Gary N.

“…Background Biomarkers in easily obtained specimens that accurately predict uveitis in children with juvenile idiopathic arthritis (JIA) are needed. Aqueous…”
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IFN-γ is essential for alveolar macrophage-driven pulmonary inflammation in macrophage activation syndrome by Gao, Denny K, Salomonis, Nathan, Henderlight, Maggie, Woods, Christopher, Thakkar, Kairavee, Grom, Alexei A, Thornton, Sherry, Jordan, Michael B, Wikenheiser-Brokamp, Kathryn A, Schulert, Grant S

“…Macrophage activation syndrome (MAS) is a life-threatening cytokine storm complicating systemic juvenile idiopathic arthritis (SJIA) driven by IFN-γ. SJIA and…”
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Saposin C coupled lipid nanovesicles specifically target arthritic mouse joints for optical imaging of disease severity by Qi, Xiaoyang, Flick, Matthew J, Frederick, Malinda, Chu, Zhengtao, Mason, Rachel, DeLay, Monica, Thornton, Sherry

“…Rheumatoid arthritis is a chronic inflammatory disease affecting approximately 1% of the population and is characterized by cartilage and bone destruction…”
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Immature cell populations and an erythropoiesis gene-expression signature in systemic juvenile idiopathic arthritis: implications for pathogenesis by Hinze, Claas H, Fall, Ndate, Thornton, Sherry, Mo, Jun Q, Aronow, Bruce J, Layh-Schmitt, Gerlinde, Griffin, Thomas A, Thompson, Susan D, Colbert, Robert A, Glass, David N, Barnes, Michael G, Grom, Alexei A

“…Previous observations suggest that active systemic juvenile idiopathic arthritis (sJIA) is associated with a prominent erythropoiesis gene-expression…”
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Urokinase plasminogen activator and receptor promote collagen-induced arthritis through expression in hematopoietic cells by Thornton, Sherry, Raghu, Harini, Cruz, Carolina, Frederick, Malinda D., Palumbo, Joseph S., Mullins, Eric S., Almholt, Kasper, Usher, Pernille A., Flick, Matthew J.

“…The plasminogen activation (PA) system has been implicated in driving inflammatory arthritis, but the precise contribution of PA system components to arthritis…”
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Inhibition of Collagen-Induced Arthritis in Mice by Viral IL-10 Gene Transfer by Ma, Yuhe, Thornton, Sherry, Duwel, Laura E, Boivin, Gregory P, Giannini, Edward H, Leiden, Jeffrey M, Bluestone, Jeffrey A, Hirsch, Raphael

“…Autoimmune arthritides are characterized by an imbalance between pro- and anti-inflammatory cytokines. Viral IL-10 (vIL-10) shares many of the…”
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Specific variations in the protocol for the induction of collagen-induced arthritis in mice improve reproducibility of disease severity and incidence in an SPF facility (BA6P.136) by Strait, Richard, Thornton, Sherry

“…Abstract Collagen-induced arthritis (CIA) is a widely used model for studying inflammatory arthritis (IA). CIA incidence and severity (I&S) varies between…”
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Heterogeneous Effects of IL-2 on Collagen-Induced Arthritis by Thornton, Sherry, Boivin, Gregory P, Kim, Kwang N, Finkelman, Fred D, Hirsch, Raphael

“…IL-2 is generally considered a pro-inflammatory cytokine that exacerbates Th1-mediated disease states, such as autoimmune arthritis. Consistent with this role…”
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Transcriptional Profiling of Tofacitinib Treatment in Juvenile Idiopathic Arthritis: Implications for Treatment Response Prediction by Eloseily, Esraa, Pickering, Alex, Dhakal, Sanjeev, Ruperto, Nicolino, Brunner, Hermine I., Grom, Alexi A., Thornton, Sherry

“…Objectives To assess changes in gene expression following tofacitinib treatment and investigate transcription patterns as potential predictors of treatment…”
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Establishing a biosafety plan for a flow cytometry shared resource laboratory by Back, Jessica B., Martinez, Lola, Nettenstrom, Lauren, Sheerar, Dagna, Thornton, Sherry

“…A biosafety plan is essential to establish appropriate practices for biosafety in a shared resource laboratory (SRL). A biosafety plan will contain the…”
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Diagnostic Accuracy Study of the Pediatric‐Specific Ultrasound Scoring System for the Knee Joint in Children With Juvenile Idiopathic Arthritis by Vega‐Fernandez, Patricia, Rogers, Kelly, Sproles, Alyssa, Thornton, Sherry, Huggins, Jennifer, Lovell, Daniel J., Cassedy, Amy, Meyers, Arthur B., Ting, Tracy V.

“…Objective We undertook this study to validate the Pediatric Arthritis Ultrasound Scoring System for the knee joint (PAUSS‐knee) in children with juvenile…”
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Monocyte MicroRNA Expression in Active Systemic Juvenile Idiopathic Arthritis Implicates MicroRNA‐125a‐5p in Polarized Monocyte Phenotypes by Schulert, Grant S., Fall, Ndate, Harley, John B., Shen, Nan, Lovell, Daniel J., Thornton, Sherry, Grom, Alexei A.

“…Objective Systemic juvenile idiopathic arthritis (JIA) is an inflammatory disease of childhood in which cells of the monomyelocytoid lineage are thought to be…”
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