Search Results - "Thornton, M. E."

Multiple ETS Factors Participate in the Transcriptional Control of TERT Mutant Promoter in Thyroid Cancers by Thornton, Caitlin E M, Hao, Jingzhu, Tamarapu, Prasanna P, Landa, Iñigo

“…Hotspot mutations in the (telomerase reverse transcriptase) gene are key determinants of thyroid cancer progression. promoter mutations (TPM) create de novo…”
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Constitutive secretion of the granule chymase mouse mast cell protease-1 and the chemokine, CCL2, by mucosal mast cell homologues by Brown, J. K., Knight, P. A., Wright, S. H., Thornton, E. M., Miller, H. R. P.

“…Summary Background The mucosal mast cell (MMC) granule‐specific β‐chymase, mouse mast cell protease‐1 (mMCP‐1), is released systemically into the bloodstream…”
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Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum by Scudamore, C L, Thornton, E M, McMillan, L, Newlands, G F, Miller, H R

“…The soluble granule chymase, rat mast cell protease-II (RMCP-II), is abundantly expressed in intestinal mucosal mast cells (MMC) but its function is not known…”
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Mast cell heterogeneity in the gastrointestinal tract: variable expression of mouse mast cell protease-1 (mMCP-1) in intraepithelial mucosal mast cells in nematode-infected and normal BALB/c mice by Scudamore, CL, McMillan, L, Thornton, EM, Wright, SH, Newlands, GF, Miller, HR

“…Soluble granule chymases in rodent intestinal mucosal mast cells (IMMCs) may play an important role in altering epithelial permeability during immediate…”
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Amniotic fluid levels of phospholipase A2 in fetal rats with retinoic acid induced myelomeningocele: the potential "second hit" in neurologic damage by Agarwal, R., Thornton, M. E., Fonteh, A. N., Harrington, M. G., Chmait, R. H., Grubbs, B. H.

“…Objectives: There is growing evidence of ongoing, in utero neurological damage in fetuses with myelomeningocele (MMC). Phospholipase A 2 (PLA 2 ) has known…”
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Do Children with Autism Who Pass False Belief Tasks Understand the Mind as Active Interpreter? by Luckett, T, Powell, S. D, Messer, D. J, Thornton, M. E, Schulz, J

“…This study compared children (n=68) with either autism or general delay on false belief tasks and tasks to test for an understanding of interpretive diversity…”
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Histochemical and Ultrastructural Modification of Mucosal Mast Cell Granules in Parasitized Mice Lacking the β-Chymase, Mouse Mast Cell Protease-1 by Wastling, Jonathan M., Knight, Pamela, Ure, Jan, Wright, Steven, Thornton, Elisabeth M., Scudamore, Cheryl L., Mason, John, Smith, Austin, Miller, Hugh R.P.

“…The soluble β-chymases mouse mast cell protease-1 (mMCP-1) and rat mast cell protease-II are predominantly expressed by intestinal mucosal mast cells (IMMCs)…”
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Constitutive expression of mouse mast cell protease‐1 in normal BALB/c mice and its up‐regulation during intestinal nematode infection by WASTLING, J. M., SCUDAMORE, C. L., THORNTON, E. M., NEWLANDS, G. F. J., MILLER, H. R. P.

“…Rodent intestinal mucosal mast cells (IMMC) store and secrete soluble granule serine proteases, the β‐chymases, which may promote epithelial permeability…”
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Recurrence of Papillary Thyroid Cancer: A Systematic Appraisal of Risk Factors by Nieto, Hannah R, Thornton, Caitlin E M, Brookes, Katie, Nobre de Menezes, Albert, Fletcher, Alice, Alshahrani, Mohammed, Kocbiyik, Merve, Sharma, Neil, Boelaert, Kristien, Cazier, Jean-Baptiste, Mehanna, Hisham, Smith, Vicki E, Read, Martin L, McCabe, Christopher J

“…Thyroid cancer recurrence is associated with increased mortality and adverse outcomes. Recurrence risk is currently predicted using clinical tools, often…”
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Telomerase Upregulation Induces Progression of Mouse BrafV600E-Driven Thyroid Cancers and Triggers Nontelomeric Effects by Landa, Iñigo, Thornton, Caitlin E M, Xu, Bin, Haase, Jacob, Krishnamoorthy, Gnana P, Hao, Jingzhu, Knauf, Jeffrey A, Herbert, Zachary T, Martínez, Paula, Blasco, María A, Ghossein, Ronald, Fagin, James A

“…Mutations in the promoter of the telomerase reverse transcriptase (TERT) gene are the paradigm of a cross-cancer alteration in a noncoding region. TERT…”
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Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake by Fletcher, Alice, Read, Martin L, Thornton, Caitlin E M, Larner, Dean P, Poole, Vikki L, Brookes, Katie, Nieto, Hannah R, Alshahrani, Mohammed, Thompson, Rebecca J, Lavery, Gareth G, Landa, Iñigo, Fagin, James A, Campbell, Moray J, Boelaert, Kristien, Turnell, Andrew S, Smith, Vicki E, McCabe, Christopher J

“…The sodium iodide symporter (NIS) is required for iodide uptake, which facilitates thyroid hormone biosynthesis. NIS has been exploited for over 75 years in…”
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Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter by Read, Martin L, Brookes, Katie, Thornton, Caitlin E M, Fletcher, Alice, Nieto, Hannah R, Alshahrani, Mohammed, Khan, Rashida, Borges de Souza, Patricia, Zha, Ling, Webster, Jamie R M, Alderwick, Luke J, Campbell, Moray J, Boelaert, Kristien, Smith, Vicki E, McCabe, Christopher J

“…The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS…”
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IgE Enhances Parasite Clearance and Regulates Mast Cell Responses in Mice Infected with Trichinella spiralis by Gurish, Michael F, Bryce, Paul J, Tao, Hong, Kisselgof, Alison B, Thornton, Elizabeth M, Miller, Hugh R, Friend, Daniel S, Oettgen, Hans C

“…Trichinella spiralis infection elicits a vigorous IgE response and pronounced intestinal and splenic mastocytosis in mice. Since IgE both activates mast cells…”
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Transforming growth factor-β1 mediates coexpression of the integrin subunit αE and the chymase mouse mast cell protease-1 during the early differentiation of bone marrow-derived mucosal mast cell homologues by WRIGHT, S. H, BROWN, J, KNIGHT, P. A, THORNTON, E. M, KILSHAW, P. J, MILLER, H. R. P

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Stem cell factor enhances immunoglobulin E‐dependent mediator release from cultured rat bone marrow‐derived mast cells: activation of previously unresponsive cells demonstrated by a novel ELISPOT assay by HILL, P. B., MACDONALD, A. J., THORNTON, E. M., NEWLANDS, G. F. J., GALLI, S. J., MILLER, H. R. P.

“…Mucosal mast cells (MMC) are important effector cells in the immune response against gastrointestinal nematodes. We used cultured rat bone marrow‐derived mast…”
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Transforming growth factor-beta(1) mediates coexpression of the integrin subunit alpha(E) and the chymase mouse mast cell protease-1 during the early differentiation of bone marrow-derived mucosal mast cell homologues by Wright, S H, Brown, J, Knight, P A, Thornton, E M

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Rat bone marrow‐derived mast cells co‐cultured with 3T3 fibroblasts in the absence of T‐cell derived cytokines require stem cell factor for their survival and maintain their mucosal mast cell‐like phenotype by MACDONALD, A. J., THORNTON, E. M., NEWLANDS, G. F. J., GALLI, S. J., MOQBEL, R., MILLER, H. R. P.

“…When cultured without fibroblasts, rat bone marrow‐derived mast cells (BMMC) contain abundant rat mast cell proteinase type II (RMCP‐II), and exhibit survival…”
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Improved hepatic and pancreatic localisation of the equine alpha-1-proteinase inhibitor family of serpins using an antigen enhancement technique and a monoclonal antibody by Dagleish, M.P., Pemberton, A.D., McAleese, S.M., Thornton, E.M., Miller, H.R.P., Scudamore, C.L.

“…Equine alpha- l-proteinase inhibitor (API) consists of three, occasionally four, serum glycoproteins. This study investigated the immunohistochemical…”
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Deleterious effects of IL-9-activated mast cells and neuroprotection by antihistamine drugs in the developing mouse brain by PATKAI, Juliana, MESPLES, Bettina, DOMMERGUES, Marie-Aliette, FROMONT, Gaëlle, THORNTION, Elisabeth M, RENAULD, Jean-Christophe, EVRARD, Philippe, GRESSENS, Pierre

“…Elevated mean IL-9 serum levels have been observed in human neonates who will later develop cerebral palsy. In earlier studies, using a newborn mouse model of…”
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A Qualitative Approach to Students’ Experiences of Character Strengths by Boyle, S. L., Martow, J. H., Thornton, E. M., Lumley, M. N.

“…For many, postsecondary study is a unique period characterized by the achievement of important developmental milestones in the context of novel stressors and…”
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