Search Results - "Thornton, C. A."

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial by SORENSON, E. J, WINDBANK, A. J, FELDMAN, E, GLASS, J, GUTMANN, L, KATZ, J, KING, W, LUCIANO, C. A, MCCLUSKEY, L. F, NASH, S, NEWMAN, D. S, PASCUZZI, R. M, MANDREKAR, J. N, PIORO, E, SAMS, L. J, SCELSA, S, SIMPSON, E. P, SUBRAMONY, S. H, TIRYAKI, E, THORNTON, C. A, BAMLET, W. R, APPEL, S. H, ARMON, C, BARKHAUS, P. E, BOSCH, P, BOYLAN, K, DAVID, W. S

“…Previous human clinical trials of insulin-like growth factor type I (IGF-1) in amyotrophic lateral sclerosis (ALS) have been inconsistent. This phase III,…”
Get full text

Mexiletine is an effective antimyotonia treatment in myotonic dystrophy type 1 by LOGIGIAN, E. L, MARTENS, W. B, MOXLEY, R. T, MCDERMOTT, M. P, DILEK, N, WIEGNER, A. W, PEARSON, A. T, BARBIERI, C. A, ANNIS, C. L, THORNTON, C. A

“…To determine if mexiletine is safe and effective in reducing myotonia in myotonic dystrophy type 1 (DM1). Myotonia is an early, prominent symptom in DM1 and…”
Get full text

HIV testing in community settings in resource‐rich countries: a systematic review of the evidence by Thornton, AC, Delpech, V, Kall, MM, Nardone, A

“…Objectives Community HIV testing represents an opportunity for diagnosing HIV infection among individuals who may not have contact with health services,…”
Get full text

Expression profile of FSHD supports a link between retinal vasculopathy and muscular dystrophy by Osborne, R J, Welle, S, Venance, S L, Thornton, C A, Tawil, R

“…Facioscapulohumeral muscular dystrophy (FSHD) is caused by deletions within a tandem array of D4Z4 repeats on chromosome 4q35. In addition to muscle…”
Get full text

Human gestation‐associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors by Bryant, A. H., Menzies, G. E., Scott, L. M., Spencer‐Harty, S., Davies, L. B., Smith, R. A., Jones, R. H., Thornton, C. A.

“…Summary The role of viral infections in adverse pregnancy outcomes has gained interest in recent years. Innate immune pattern recognition receptors (PRRs) and…”
Get full text

The hypocretin neurotransmission system in myotonic dystrophy type 1 by CIAFALONI, E, MIGNOT, E, SANSONE, V, HILBERT, J. E, LIN, L, LIN, X, LIU, L. C, PIGEON, W. R, PERILS, M. L, THORNTON, C. A

“…Patients with myotonic dystrophy type 1 (DM1) frequently have symptoms of excessive daytime sleepiness (EDS). Some patients with DM1 show sleep-onset REM,…”
Get full text

An introduction to Toll‐like receptors and their possible role in the initiation of labour by Patni, S, Flynn, P, Wynen, LP, Seager, AL, Morgan, G, White, JO, Thornton, CA

“…Toll‐like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the…”
Get full text

Bioenergetic analysis of human peripheral blood mononuclear cells by Jones, N., Piasecka, J., Bryant, A. H., Jones, R. H., Skibinski, D. O. F., Francis, Nigel. J., Thornton, C. A.

“…Summary Leucocytes respond rapidly to pathogenic and other insults, with responses ranging from cytokine production to migration and phagocytosis. These are…”
Get full text

Exposure of the fetus and infant to hens' egg ovalbumin via the placenta and breast milk in relation to maternal intake of dietary egg by Vance, G. H. S., Lewis, S. A., Grimshaw, K. E. C., Wood, P. J., Briggs, R. A., Thornton, C. A., Warner, J. O.

“…Summary Background Maternally derived allergens may be transferred to the developing infant during pregnancy and lactation. However, it is not known how…”
Get full text

Myotonic Dystrophy in Transgenic Mice Expressing an Expanded CUG Repeat by Mankodi, Ami, Logigian, Eric, Callahan, Linda, McClain, Carolyn, White, Robert, Henderson, Don, Krym, Matt, Thornton, Charles A.

“…Myotonic dystrophy (DM), the most common form of muscular dystrophy in adult humans, results from expansion of a CTG repeat in the 3′ untranslated region of…”
Get full text

Quantitative assessment of motor fatigue and strength in MS by SCHWID, S. R, THORNTON, C. A, PANDYA, S, MANZUR, K. L, SANJAK, M, PETRIE, M. D, MCDERMOTT, M. P, GOODMAN, A. D

“…To determine the test-retest reliability of strength and fatigue measurements in patients with MS and in healthy control subjects, and to examine associations…”
Get full text

Indoor/outdoor relationships of particulate matter in domestic homes with roadside, urban and rural locations by Jones, N.C, Thornton, C.A, Mark, D, Harrison, R.M

“…Particulate matter was measured inside and outside seven homes within Birmingham, UK, and two homes in rural locations during a 12 month period. Two of the…”
Get full text

Quantitative analysis of the "warm-up" phenomenon in myotonic dystrophy type 1 by Logigian, E. L., Blood, C. L., Dilek, N., Martens, W. B., Moxley IV, R. T., Wiegner, A. W., Thornton, C. A., Moxley III, R. T.

“…To quantitate improvement in hand‐grip myotonia and muscle strength (i.e., the “warm‐up” phenomenon) in myotonic dystrophy type 1 (DM1), six successive,…”
Get full text

Estimated cost per HIV infection diagnosed through routine HIV testing offered in acute general medical admission units and general practice settings in England by Ong, KJ, Thornton, AC, Fisher, M, Hutt, R, Nicholson, S, Palfreeman, A, Perry, N, Stedman‐Bryce, G, Wilkinson, P, Delpech, V, Nardone, A

“…Objectives Following national guidelines to expand HIV testing in high‐prevalence areas in England, a number of pilot studies were conducted in acute general…”
Get full text

Serum ovalbumin-specific immunoglobulin G responses during pregnancy reflect maternal intake of dietary egg and relate to the development of allergy in early infancy by Vance, G. H. S., Grimshaw, K. E. C., Briggs, R., Lewis, S. A., Mullee, M. A., Thornton, C. A., Warner, J. O.

“…Summary Background The value of allergen elimination diets during pregnancy for primary prevention of infant allergy has been questioned. However, dietary…”
Get full text

Personal exposure monitoring of particulate matter, nitrogen dioxide, and carbon monoxide, including susceptible groups by Harrison, R M, Thornton, C A, Lawrence, R G, Mark, D, Kinnersley, R P, Ayres, J G

“…Aims: To investigate the relation between personal exposures to nitrogen dioxide, carbon monoxide, and PM10, and exposures estimated from static concentrations…”
Get full text

Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods by Prescott, S. L., Taylor, A., King, B., Dunstan, J., Upham, J. W., Thornton, C. A., Holt, P. G.

“…Summary Background and objectives A reduced capacity of antigen presenting cells (APC) to provide pro‐T helper 1 (Th1) signals, such as IL‐12, to T cells…”
Get full text

Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene by Thornton, Charles A, Wymer, James P, Simmons, Zachary, McClain, Carolyn, Moxley, Richard T

“…Myotonic dystrophy, or dystrophia myotonica (DM), is a highly variable multisystem disease in which the classic adult-onset form displays progressive muscle…”
Get full text

Mechanisms of allergic disease - environmental and genetic determinants for the development of allergy by Campbell, D. E., Boyle, R. J., Thornton, C. A., Prescott, S. L.

“…Summary Allergic disease can be viewed as an early manifestation of immune dysregulation. Environmental exposures including maternal inflammation, diet,…”
Get full text

Randomized controlled trial of IVIg in untreated chronic inflammatory demyelinating polyradiculoneuropathy by MENDELL, J. R, BAROHN, R. J, LEWIS, R. A, SHY, M, SIMPSON, D. M, PARRY, G. J, RIVNER, M. H, THORNTON, C. A, BROMBERG, M. B, TANDAN, R, HARATI, Y, GIULIANI, M. J, FREIMER, M. L, KISSEL, J. T, KING, W, NAGARAJA, H. N, RICE, R, CAMPBELL, W. W, DONOFRIO, P. D, JACKSON, C. E

“…To determine the efficacy of IV immunoglobulin (IVIg) given patients with untreated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). A…”
Get full text