Search Results - "Thorne, S H"

Synergistic anti-tumor effects between oncolytic vaccinia virus and paclitaxel are mediated by the IFN response and HMGB1 by Huang, B, Sikorski, R, Kirn, D H, Thorne, S H

“…Recent developments in the field of oncolytic or tumor-selective viruses have meant that the clinical applications of these agents are now being considered in…”
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Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model by Kim, J, Thorne, S H, Sun, L, Huang, B, Mochly-Rosen, D

“…Metastasis is the major reason for breast cancer-related deaths. Although there is a host of indirect evidence for a role of protein kinase C (PKC) α in…”
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Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells by Zou, Y, Li, F, Hou, W, Sampath, P, Zhang, Y, Thorne, S H

“…Background: Cytokine-induced killer (CIK) cells are ex vivo -expanded immune cells that express NK-cell and T-cell markers and that are routinely used in the…”
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Combining immune cell and viral therapy for the treatment of cancer by Thorne, S. H, Contag, C. H

“…A variety of viral-based and immune cell therapies have been proposed for use in the treatment of cancer. One possible approach to improve the effectiveness of…”
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CTL- vs Treg lymphocyte-attracting chemokines, CCL4 and CCL20, are strong reciprocal predictive markers for survival of patients with oesophageal squamous cell carcinoma by Liu, J Y, Li, F, Wang, L P, Chen, X F, Wang, D, Cao, L, Ping, Y, Zhao, S, Li, B, Thorne, S H, Zhang, B, Kalinski, P, Zhang, Y

“…Background: Tumoural infiltration of T lymphocytes is determined by local patterns of specific chemokine expression. In this report, we examined the roles of…”
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Systemic Armed Oncolytic and Immunologic Therapy for Cancer with JX-594, a Targeted Poxvirus Expressing GM-CSF by Kim, J H, Oh, J Y, Park, B H, Lee, D E, Kim, J S, Park, H E, Roh, M S, Je, J E, Yoon, J H, Thorne, S H, Kirn, D, Hwang, T H

“…Targeted oncolytic viruses and immunostimulatory therapeutics are being developed as novel cancer treatment platforms. These approaches can be combined through…”
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Potential for enhanced therapeutic activity of biological cancer therapies with doxycycline combination by Tang, H, Sampath, P, Yan, X, Thorne, S H

“…Despite significant strides made in the clinical translation of adoptive immune cell therapies, it is apparent that many tumors incorporate strategies to avoid…”
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Integrating the biological characteristics of oncolytic viruses and immune cells can optimize therapeutic benefits of cell-based delivery by Thorne, S H, Contag, C H

“…Despite significant advances in the development of tumor-selective agents, strategies for effective delivery of these agents across biological barriers to…”
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Adaptation to nutrient starvation in Rhizobium leguminosarum bv. phaseoli: analysis of survival, stress resistance, and changes in macromolecular synthesis during entry to and exit from stationary phase by Thorne, S.H, Williams, H.D

“…The nitrogen-fixing bacterium Rhizobium leguminosarum bv. phaseoli often has to survive long periods of starvation in the soil, when not in a useful symbiotic…”
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Cell density-dependent starvation survival of Rhizobium leguminosarum bv. phaseoli: identification of the role of an N-acyl homoserine lactone in adaptation to stationary-phase survival by Thorne, S.H, Williams, H.D

“…The cell density dependence of stationary-phase survival of Rhizobium leguminosarum has been investigated. Following starvation by exhaustion or carbon or…”
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CTL- vs T sub(reg) lymphocyte-attracting chemokines, CCL4 and CCL20, are strong reciprocal predictive markers for survival of patients with oesophageal squamous cell carcinoma by Liu, J Y, Li, F, Wang, L P, Chen, X F, Wang, D, Cao, L, Ping, Y, Zhao, S, Li, B, Thorne, S H, Zhang, B, Kalinski, P, Zhang, Y

“…Background: Tumoural infiltration of T lymphocytes is determined by local patterns of specific chemokine expression. In this report, we examined the roles of…”
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Integrating the biological characteristics of oncolytic viruses and immune cells can optimize therapeutic benefits of cell-based delivery: Cellular Vehicles for Gene Therapy by THORNE, S. H, CONTAG, C. H

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Sustained inhibition of PKC[alpha] reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model by Kim, J, Thorne, S H, Sun, L, Huang, B, Mochly-rosen, D

“…Metastasis is the major reason for breast cancer-related deaths. Although there is a host of indirect evidence for a role of protein kinase C (PKC) [alpha] in…”
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Synergistic Antitumor Effects of Immune Cell-Viral Biotherapy by Thorne, Steve H, Negrin, Robert S, Contag, Christopher H

“…Targeted biological therapies hold tremendous potential for treatment of cancer, yet their use has been limited by constraints on delivery and effective tumor…”
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Expression of CCL19 from Oncolytic Vaccinia Enhances Immunotherapeutic Potential while Maintaining Oncolytic Activity by Li, Jun, O'Malley, Mark, Sampath, Padma, Kalinski, Pawel, Bartlett, David L, Thorne, Steve H

“…Promising phase II clinical results have been reported recently for several oncolytic viral therapeutics, including strains based on vaccinia virus. One reason…”
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Modulation of NKG2D-ligand Cell Surface Expression Enhances Immune Cell Therapy of Cancer by BAOCHENG HUANG, SIKORSKI, Rachel, SAMPATH, Padma, THORNE, Stephen H

“…A variety of immune cell therapies proposed for use in the treatment of cancer, including both autologous cells (Lymphokine Activated Killer, Cytokine Induced…”
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Consensus guidelines for the detection of immunogenic cell death by Kepp, Oliver, Senovilla, Laura, Vitale, Ilio, Vacchelli, Erika, Adjemian, Sandy, Agostinis, Patrizia, Apetoh, Lionel, Aranda, Fernando, Barnaba, Vincenzo, Bloy, Norma, Bracci, Laura, Breckpot, Karine, Brough, David, Buqué, Aitziber, Castro, Maria G., Cirone, Mara, Colombo, Maria I., Cremer, Isabelle, Demaria, Sandra, Dini, Luciana, Eliopoulos, Aristides G., Faggioni, Alberto, Formenti, Silvia C., Fučíková, Jitka, Gabriele, Lucia, Gaipl, Udo S., Galon, Jérôme, Garg, Abhishek, Ghiringhelli, François, Giese, Nathalia A., Guo, Zong Sheng, Hemminki, Akseli, Herrmann, Martin, Hodge, James W., Holdenrieder, Stefan, Honeychurch, Jamie, Hu, Hong-Min, Huang, Xing, Illidge, Tim M., Kono, Koji, Korbelik, Mladen, Krysko, Dmitri V., Loi, Sherene, Lowenstein, Pedro R., Lugli, Enrico, Ma, Yuting, Madeo, Frank, Manfredi, Angelo A., Martins, Isabelle, Mavilio, Domenico, Menger, Laurie, Merendino, Nicolò, Michaud, Michael, Mignot, Gregoire, Mossman, Karen L., Multhoff, Gabriele, Oehler, Rudolf, Palombo, Fabio, Panaretakis, Theocharis, Pol, Jonathan, Proietti, Enrico, Ricci, Jean-Ehrland, Riganti, Chiara, Rovere-Querini, Patrizia, Rubartelli, Anna, Sistigu, Antonella, Smyth, Mark J., Sonnemann, Juergen, Spisek, Radek, Stagg, John, Sukkurwala, Abdul Qader, Tartour, Eric, Thorburn, Andrew, Thorne, Stephen H., Vandenabeele, Peter, Velotti, Francesca, Workenhe, Samuel T., Yang, Haining, Zong, Wei-Xing, Zitvogel, Laurence, Kroemer, Guido, Galluzzi, Lorenzo

“…Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens…”
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A preclinical study of cellular immunotherapy redirected by bispecific antibodies in uterine cell lines and primary cancer cells by Hamilton, C. A., Zhang, M. M., Chan, J. K., Cheung, M. K., Thorne, S. H., Baker, J., Contag, C. H., Negrin, R. S.

“…Abstract only 15044 Background: Cytokine induced killer cells (CIKs) are ex-vivo activated and expanded CD8+ natural killer T cells that have been shown to…”
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Oncolytic Virotherapy: Approaches to Tumor Targeting and Enhancing Antitumor Effects by Thorne, Stephen H., Hermiston, Terry, Kirn, David

“…The application of replicating viruses for the treatment of cancers represents a novel therapy that is distinct from traditional treatment modalities. It is…”
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Ethyl pyruvate administration inhibits hepatic tumor growth by Liang, X, de Vivar Chavez, AR, Schapiro, N E, Loughran, P, Thorne, SH, Amoscato, A A, Zeh, HJ, Beer-Stolz, D, Lotze, M T, de Vera, ME

“…The first demonstration of ethyl pyruvate inhibition of liver tumor growth associated with induction of tumor apoptosis, diminished HMGB1 release, and…”
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