Search Results - "Thorne, G"

Intranasal delivery of biologics to the central nervous system by Lochhead, Jeffrey J., Thorne, Robert G.

“…Treatment of central nervous system (CNS) diseases is very difficult due to the blood–brain barrier's (BBB) ability to severely restrict entry of all but…”
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Norovirus gene expression and replication by Thorne, Lucy G, Goodfellow, Ian G

“…Noroviruses are small, positive-sense RNA viruses within the family Caliciviridae, and are now accepted widely as a major cause of acute gastroenteritis in…”
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SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation by Thorne, Lucy G, Reuschl, Ann‐Kathrin, Zuliani‐Alvarez, Lorena, Whelan, Matthew V X, Turner, Jane, Noursadeghi, Mahdad, Jolly, Clare, Towers, Greg J

“…SARS‐CoV‐2 infection causes broad‐spectrum immunopathological disease, exacerbated by inflammatory co‐morbidities. A better understanding of mechanisms…”
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Diffusion of Macromolecules in the Brain: Implications for Drug Delivery by Wolak, Daniel J, Thorne, Robert G

“…Therapeutics must diffuse through the brain extracellular space (ECS) in order to distribute within the central nervous system (CNS) compartment; this…”
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In vivo Diffusion Analysis with Quantum Dots and Dextrans Predicts the Width of Brain Extracellular Space by Thorne, Robert G., Nicholson, Charles

“…Diffusion within the extracellular space (ECS) of the brain is necessary for chemical signaling and for neurons and glia to access nutrients and therapeutics;…”
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Rapid Transport within Cerebral Perivascular Spaces Underlies Widespread Tracer Distribution in the Brain after Intranasal Administration by Lochhead, Jeffrey J, Wolak, Daniel J, Pizzo, Michelle E, Thorne, Robert G

“…The intranasal administration route is increasingly being used as a noninvasive method to bypass the blood—brain barrier because evidence suggests small…”
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Molecular characterization of perivascular drainage pathways in the murine brain by Hannocks, Melanie-Jane, Pizzo, Michelle E, Huppert, Jula, Deshpande, Tushar, Abbott, N Joan, Thorne, Robert G, Sorokin, Lydia

“…Perivascular compartments surrounding central nervous system (CNS) vessels have been proposed to serve key roles in facilitating cerebrospinal fluid flow into…”
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Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery by Pizzo, Michelle E., Wolak, Daniel J., Kumar, Niyanta N., Brunette, Eric, Brunnquell, Christina L., Hannocks, Melanie‐Jane, Abbott, N. Joan, Meyerand, M. Elizabeth, Sorokin, Lydia, Stanimirovic, Danica B., Thorne, Robert G.

“…Key points It is unclear precisely how macromolecules (e.g. endogenous proteins and exogenous immunotherapeutics) access brain tissue from the cerebrospinal…”
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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys by Kariolis, Mihalis S, Wells, Robert C, Getz, Jennifer A, Kwan, Wanda, Mahon, Cathal S, Tong, Raymond, Kim, Do Jin, Srivastava, Ankita, Bedard, Catherine, Henne, Kirk R, Giese, Tina, Assimon, Victoria A, Chen, Xiaocheng, Zhang, Yin, Solanoy, Hilda, Jenkins, Katherine, Sanchez, Pascal E, Kane, Lesley, Miyamoto, Takashi, Chew, Kylie S, Pizzo, Michelle E, Liang, Nicholas, Calvert, Meredith E K, DeVos, Sarah L, Baskaran, Sulochanadevi, Hall, Sejal, Sweeney, Zachary K, Thorne, Robert G, Watts, Ryan J, Dennis, Mark S, Silverman, Adam P, Zuchero, Y Joy Yu

“…Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the…”
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Delivery of immunoglobulin G antibodies to the rat nervous system following intranasal administration: Distribution, dose-response, and mechanisms of delivery by Kumar, Niyanta N., Lochhead, Jeffrey J., Pizzo, Michelle E., Nehra, Geetika, Boroumand, Sam, Greene, Gretchen, Thorne, Robert G.

“…The intranasal route has been hypothesized to circumvent the blood-brain and blood-cerebrospinal fluid barriers, allowing entry into the brain via…”
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Metabolic engineering of a thermophilic bacterium to produce ethanol at high yield by Shaw, A. Joe, Podkaminer, Kara K, Desai, Sunil G, Bardsley, John S, Rogers, Stephen R, Thorne, Philip G, Hogsett, David A, Lynd, Lee R

“…We report engineering Thermoanaerobacterium saccharolyticum, a thermophilic anaerobic bacterium that ferments xylan and biomass-derived sugars, to produce…”
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Blood-brain borders: a proposal to address limitations of historical blood-brain barrier terminology by Badaut, Jerome, Ghersi-Egea, Jean-François, Thorne, Robert G, Konsman, Jan Pieter

“…Many neuroscientists use the term Blood-Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight…”
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Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration by Thorne, R.G., Pronk, G.J., Padmanabhan, V., Frey, W.H.

“…We investigated the CNS delivery of insulin-like growth factor-I (IGF-I), a 7.65 kDa protein neurotrophic factor, following intranasal administration and the…”
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In vivo Diffusion of Lactoferrin in Brain Extracellular Space Is Regulated by Interactions with Heparan Sulfate by Thorne, Robert G., Lakkaraju, Aparna, Rodriguez-Boulan, Enrique, Nicholson, Charles

“…The intercellular spaces between neurons and glia contain an amorphous, negatively charged extracellular matrix (ECM) with the potential to shape and regulate…”
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Relative vascular permeability and vascularity across different regions of the rat nasal mucosa: implications for nasal physiology and drug delivery by Kumar, Niyanta N., Gautam, Mohan, Lochhead, Jeffrey J., Wolak, Daniel J., Ithapu, Vamsi, Singh, Vikas, Thorne, Robert G.

“…Intranasal administration provides a non-invasive drug delivery route that has been proposed to target macromolecules either to the brain via direct…”
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Trace Element Characteristics of Pyrite and Arsenopyrite from the Golden Ridge Gold Deposit, New Brunswick, Canada: Implications for Ore Genesis by Alan Cardenas-Vera, Moya MacDonald, David R. Lentz, Kathleen G. Thorne

“…The Golden Ridge gold deposit is located in southwestern New Brunswick, in the Canadian Appalachians. Gold mineralization is consistently associated with…”
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Development of High-Silica Adakitic Intrusions in the Northern Appalachians of New Brunswick (Canada), and Their Correlation with Slab Break-Off: Insights into the Formation of Fertile Cu-Au-Mo Porphyry Systems by Yousefi, Fazilat, Lentz, David R., Walker, James A., Thorne, Kathleen G.

“…High-silica adakites exhibit specific compositions, as follows: SiO2 ≥ 56 wt.%, Al2O3 ≥ 15 wt.%, Y ≤ 18 ppm, Yb ≤ 1.9 ppm, K2O/Na2O ≥ 1, MgO < 3 wt.%, high…”
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Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats by Nehra, Geetika, Andrews, Shannon, Rettig, Joan, Gould, Michael N., Haag, Jill D., Howard, Steven P., Thorne, Robert G.

“…Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been…”
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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes by Wang, Xiang, Bondar, Vitaliy V, Davis, Oliver B, Maloney, Michael T, Agam, Maayan, Chin, Marcus Y, Cheuk-Nga Ho, Audrey, Ghosh, Rajarshi, Leto, Dara E, Joy, David, Calvert, Meredith E K, Lewcock, Joseph W, Di Paolo, Gilbert, Thorne, Robert G, Sweeney, Zachary K, Henry, Anastasia G

“…Leucine-rich repeat kinase 2 (LRRK2) variants associated with Parkinson's disease (PD) and Crohn's disease lead to increased phosphorylation of its Rab…”
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Petrogenesis of Eagle Lake Granite and Its Associated Cu–Mo–Au Mineralization, Southwestern New Brunswick, Canada by Fazilat Yousefi, David R. Lentz, Kathleen G. Thorne, Christopher R. M. McFarlane, Brian Cousens

“…The NE-trending multiphase Late Devonian Eagle Lake granite (ELG) in southwestern New Brunswick is mineralized, consisting of hypabyssal porphyritic stocks and…”
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