Search Results - "Thornburn, Anna"
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Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source
Published in Nature cell biology (01-04-2014)“…Increased visceral adipose tissue has been associated with metabolic dysfunction but the origin of the progenitors that give rise to this tissue, and whether…”
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Acute multiple organ failure in adult mice deleted for the developmental regulator Wt1
Published in PLoS genetics (01-12-2011)“…There is much interest in the mechanisms that regulate adult tissue homeostasis and their relationship to processes governing foetal development. Mice deleted…”
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Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis
Published in PLoS genetics (05-04-2021)“…Mammalian Hedgehog (HH) signalling pathway plays an essential role in tissue homeostasis and its deregulation is linked to rheumatological disorders. UBR5 is…”
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Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice
Published in Disease models & mechanisms (01-08-2015)“…Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically…”
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A universal vector for high-efficiency multi-fragment recombineering of BACs and knock-in constructs
Published in PloS one (29-04-2013)“…There is an increasing need for more efficient generation of transgenic constructs. Here we present a universal multi-site Gateway vector for use in…”
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WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel
Published in Scientific reports (27-03-2017)“…WT1 is a transcription factor which regulates the epithelial-mesenchymal balance during embryonic development and, if mutated, can lead to the formation of…”
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WT1 regulates the expression of inhibitory chemokines during heart development
Published in Human molecular genetics (20-12-2013)“…The embryonic epicardium is an important source of cardiovascular precursor cells and paracrine factors that are required for adequate heart formation…”
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Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice
Published in Development (Cambridge) (15-08-2015)Get full text
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Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1 mutants
Published in Disease models & mechanisms (01-01-2015)“…Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best…”
Get full text
Journal Article -
10
Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1: e1002404
Published in PLoS genetics (01-12-2011)“…There is much interest in the mechanisms that regulate adult tissue homeostasis and their relationship to processes governing foetal development. Mice deleted…”
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Journal Article