Search Results - "Thornburg, Kent"

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    Placental Origins of Chronic Disease by Burton, Graham J, Fowden, Abigail L, Thornburg, Kent L

    Published in Physiological reviews (01-10-2016)
    “…Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to events during their intrauterine phase of development…”
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    Journal Article
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    The placenta is the center of the chronic disease universe by Thornburg, Kent L., PhD, Marshall, Nicole, MD

    “…Over the past quarter century it has become clear that adult onset chronic diseases like heart disease and type 2 diabetes have their roots in early…”
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    Nutrition in adolescents: physiology, metabolism, and nutritional needs by Das, Jai K., Salam, Rehana A., Thornburg, Kent L., Prentice, Andrew M., Campisi, Susan, Lassi, Zohra S., Koletzko, Berthold, Bhutta, Zulfiqar A.

    Published in Annals of the New York Academy of Sciences (01-04-2017)
    “…Adolescence is the period of development that begins at puberty and ends in early adulthood. Most commonly, adolescence is divided into three developmental…”
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    Physiological response to fetal intravenous lipid emulsion by Piccolo, Brian D, Chen, Athena, Louey, Samantha, Thornburg, Kent L R, Jonker, Sonnet S

    Published in Clinical science (1979) (07-02-2024)
    “…In preterm neonates unable to obtain sufficient oral nutrition, intravenous lipid emulsion is life-saving. The contribution of post-conceptional level of…”
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    Journal Article
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    Effect of In Utero and Early-Life Conditions on Adult Health and Disease by Gluckman, Peter D, Hanson, Mark A, Cooper, Cyrus, Thornburg, Kent L

    Published in The New England journal of medicine (03-07-2008)
    “…Many lines of evidence, including epidemiologic data and extensive clinical and experimental studies, indicate that early life events play a powerful role in…”
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    Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart by Drake, Rachel R., Louey, Samantha, Thornburg, Kent L.

    Published in The Journal of physiology (01-02-2022)
    “…At birth, the mammalian myocardium switches from using carbohydrates as the primary energy substrate to free fatty acids as the primary fuel. Thus, a…”
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    Maturation of lipid metabolism in the fetal and newborn sheep heart by Drake, Rachel R, Louey, Samantha, Thornburg, Kent L

    “…At birth, the fetus experiences a dramatic change in environment that is accompanied by a shift in myocardial fuel preference from lactate and glucose in fetal…”
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    Cytotrophoblast, Not Syncytiotrophoblast, Dominates Glycolysis and Oxidative Phosphorylation in Human Term Placenta by Kolahi, Kevin S., Valent, Amy M., Thornburg, Kent L.

    Published in Scientific reports (23-02-2017)
    “…The syncytiotrophoblast (SCT) at the maternal-fetal interface has been presumed to be the primary driver of placental metabolism, and the underlying progenitor…”
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    The Obstetric Origins of Health for a Lifetime by BARKER, DAVID J.P, THORNBURG, KENT L

    Published in Clinical obstetrics and gynecology (01-09-2013)
    “…There is a new “developmental” model for the origins of a wide range of chronic diseases. Under this model the causes to be identified are linked to normal…”
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    Real-Time Tracking of BODIPY-C12 Long-Chain Fatty Acid in Human Term Placenta Reveals Unique Lipid Dynamics in Cytotrophoblast Cells by Kolahi, Kevin, Louey, Samantha, Varlamov, Oleg, Thornburg, Kent

    Published in PloS one (28-04-2016)
    “…While the human placenta must provide selected long-chain fatty acids to support the developing fetal brain, little is known about the mechanisms underlying…”
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    Effects of Prenatal Nutrition and the Role of the Placenta in Health and Disease by Myatt, Leslie, Thornburg, Kent L

    “…Epidemiologic studies identified the linkage between exposures to stresses, including the type and plane of nutrition in utero with development of disease in…”
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    Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing by Valent, Amy M., Choi, Haeri, Kolahi, Kevin S., Thornburg, Kent L.

    Published in The FASEB journal (01-03-2021)
    “…The degree that maternal glycemia affects placental metabolism of trophoblast cell types [cytotrophoblast (CTB) and syncytiotrophoblast (SCT)] in pregnant…”
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    Biological features of placental programming by Thornburg, Kent L, Kolahi, Kevin, Pierce, Melinda, Valent, Amy, Drake, Rachel, Louey, Samantha

    Published in Placenta (Eastbourne) (01-12-2016)
    “…Abstract The placenta is a key organ in programming the fetus for later disease. This review outlines nine of many structural and physiological features of the…”
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    Maternal Malnutrition and Elevated Disease Risk in Offspring by Thornburg, Kent L, Valent, Amy M

    Published in Nutrients (08-08-2024)
    “…US populations have seen dramatic increases in the prevalence of chronic disease over the past three generations. Rapid increases in type 2 diabetes and…”
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