Search Results - "Thorman, Alexander"

Biases in the experimental annotations of protein function and their effect on our understanding of protein function space by Schnoes, Alexandra M, Ream, David C, Thorman, Alexander W, Babbitt, Patricia C, Friedberg, Iddo

“…The ongoing functional annotation of proteins relies upon the work of curators to capture experimental findings from scientific literature and apply them to…”
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Using difference-in-difference to understand the downside to antibiotic use during infancy by Thorman, Alexander W., Taft, Diana H.

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Validation of collection and anaerobic fermentation techniques for measuring prebiotic impact on gut microbiota by Thorman, Alexander W., Morrow, Ardythe L., Groeneveld, Andre, Nauta, Arjen, Newburg, David S.

“…Defining the ability of prebiotic dietary carbohydrates to influence the composition and metabolism of the gut microbiota is central to defining their health…”
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Hiding in plain sight: immune evasion by the staphylococcal protein SdrE by Herr, Andrew B, Thorman, Alexander W

“…The human immune system is responsible for identification and destruction of invader cells, such as the bacterial pathogen In response, brings to the fight a…”
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Gut Microbiome Composition and Metabolic Capacity Differ by FUT2 Secretor Status in Exclusively Breastfed Infants by Thorman, Alexander W, Adkins, Grace, Conrey, Shannon C, Burrell, Allison R, Yu, Ying, White, Brendon, Burke, Rachel, Haslam, David, Payne, Daniel C, Staat, Mary A, Morrow, Ardythe L, Newburg, David S

“…A major polymorphism in the fucosyltransferase2 (FUT2) gene influences risk of multiple gut diseases, but its impact on the microbiome of breastfed infants was…”
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Correlates of Rotavirus Vaccine Shedding and Seroconversion in a US Cohort of Healthy Infants by Burke, Rachel M, Payne, Daniel C, McNeal, Monica, Conrey, Shannon C, Burrell, Allison R, Mattison, Claire P, Casey-Moore, Mary C, Mijatovic-Rustempasic, Slavica, Gautam, Rashi, Esona, Mathew D, Thorman, Alexander W, Bowen, Michael D, Parashar, Umesh D, Tate, Jacqueline E, Morrow, Ardythe L, Staat, Mary A

“…Abstract Background Rotavirus is a leading cause of severe pediatric gastroenteritis; 2 highly effective vaccines are used in the United States (US). We aimed…”
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Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach by O’Donovan, Sinead M., Imami, Ali, Eby, Hunter, Henkel, Nicholas D., Creeden, Justin Fortune, Asah, Sophie, Zhang, Xiaolu, Wu, Xiaojun, Alnafisah, Rawan, Taylor, R. Travis, Reigle, James, Thorman, Alexander, Shamsaei, Behrouz, Meller, Jarek, McCullumsmith, Robert E.

“…The COVID-19 pandemic caused by the novel SARS-CoV-2 is more contagious than other coronaviruses and has higher rates of mortality than influenza…”
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Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking by Thorman, Alexander W, Reigle, James, Chutipongtanate, Somchai, Yang, Juechen, Shamsaei, Behrouz, Pilarczyk, Marcin, Fazel-Najafabadi, Mehdi, Adamczak, Rafal, Kouril, Michal, Bhatnagar, Surbhi, Hummel, Sarah, Niu, Wen, Morrow, Ardythe L, Czyzyk-Krzeska, Maria F, McCullumsmith, Robert, Seibel, William, Nassar, Nicolas, Zheng, Yi, Hildeman, David A, Medvedovic, Mario, Herr, Andrew B, Meller, Jarek

“…We present an in silico approach for drug discovery, dubbed connectivity enhanced structure activity relationship (ceSAR). Building on the landmark LINCS…”
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Connectivity Enhanced Structure Activity Relationship (ceSAR): A Novel Approach to Increase Accuracy and Speed of Virtual Drug Discovery by Thorman, Alexander William, Reigle, James, Chutipongtanate, Somchai, Shamsaei, Behrouz, Pilarczyk, Marcin, Fazel-Najafabadi, Mehdi, Adamczak, Rafal, Kouril, Michal, Medvedovic, Mario, Meller, Jarek

“…Abstract only…”
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Maternal FUT2 genotype in relation to risk of acute infections and rotavirus vaccine shedding in infancy by Adkins, Grace E., Thorman, Alexander, Conrey, Shannon C., Cline, Allison R., Staat, Mary A., Payne, Daniel C., Piasecki, Alexandra M., Burke, Rachel M., Bowen, Michael D., Morrow, Ardythe L.

“…Abstract only…”
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Rational Design of Novel BCL2A1 Inhibitors for Treatment of Autoimmune Diseases: An Integration of Virtual Screening, Transcriptomics and Protein Biophysics by Thorman, Alexander

“…The balance between cell survival and apoptosis is critical to the modulation of immune responses and misregulation of this balance often mediates diseases…”
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Biases in the Experimental Annotations of Protein Function and Their Effect on Our Understanding of Protein Function Space: e1003063 by Schnoes, Alexandra M, Ream, David C, Thorman, Alexander W, Babbitt, Patricia C, Friedberg, Iddo

“…The ongoing functional annotation of proteins relies upon the work of curators to capture experimental findings from scientific literature and apply them to…”
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Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO) by Jolene Ramsey, Brenley McIntosh, Daniel Renfro, Suzanne A. Aleksander, Sandra LaBonte, Curtis Ross, Adrienne E. Zweifel, Nathan Liles, Shabnam Farrar, Jason J. Gill, Ivan Erill, Sarah Ades, Tanya Z. Berardini, Jennifer A. Bennett, Siobhan Brady, Robert Britton, Seth Carbon, Steven M. Caruso, Dave Clements, Ritu Dalia, Meredith Defelice, Erin L. Doyle, Iddo Friedberg, Susan M. R. Gurney, Lee Hughes, Allison Johnson, Jason M. Kowalski, Donghui Li, Ruth C. Lovering, Tamara L. Mans, Fiona McCarthy, Sean D. Moore, Rebecca Murphy, Timothy D. Paustian, Sarah Perdue, Celeste N. Peterson, Birgit M. Prüß, Margaret S. Saha, Robert R. Sheehy, John T. Tansey, Louise Temple, Alexander William Thorman, Saul Trevino, Amy Cheng Vollmer, Virginia Walbot, Joanne Willey, Deborah A. Siegele, James C. Hu

“…Experimental data about gene functions curated from the primary literature have enormous value for research scientists in understanding biology. Using the Gene…”
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Crowdsourcing biocuration: The Community Assessment of Community Annotation with Ontologies (CACAO) by Ramsey, Jolene, McIntosh, Brenley, Renfro, Daniel, Aleksander, Suzanne A, LaBonte, Sandra, Ross, Curtis, Zweifel, Adrienne E, Liles, Nathan, Farrar, Shabnam, Gill, Jason J, Erill, Ivan, Ades, Sarah, Berardini, Tanya Z, Bennett, Jennifer A, Brady, Siobhan, Britton, Robert, Carbon, Seth, Caruso, Steven M, Clements, Dave, Dalia, Ritu, Defelice, Meredith, Doyle, Erin L, Friedberg, Iddo, Gurney, Susan M R, Hughes, Lee, Johnson, Allison, Kowalski, Jason M, Li, Donghui, Lovering, Ruth C, Mans, Tamara L, McCarthy, Fiona, Moore, Sean D, Murphy, Rebecca, Paustian, Timothy D, Perdue, Sarah, Peterson, Celeste N, Prüß, Birgit M, Saha, Margaret S, Sheehy, Robert R, Tansey, John T, Temple, Louise, Thorman, Alexander William, Trevino, Saul, Vollmer, Amy Cheng, Walbot, Virginia, Willey, Joanne, Siegele, Deborah A, Hu, James C

“…Experimental data about gene functions curated from the primary literature have enormous value for research scientists in understanding biology. Using the Gene…”
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Biases in the Experimental Annotations of Protein Function and their Effect on Our Understanding of Protein Function Space by Schnoes, Alexandra M, Ream, David C, Thorman, Alexander W, Babbitt, Patricia C, Friedberg, Iddo

“…The ongoing functional annotation of proteins relies upon the work of curators to capture experimental findings from scientific literature and apply them to…”
Get full text