Search Results - "Thoren, Katie L."

Will Mass Spectrometry Replace Current Techniques for Both Routine Monitoring and MRD Detection in Multiple Myeloma? by Thoren, Katie L.

“…In recent years, mass spectrometry has been increasingly used for the detection of monoclonal proteins in serum. Mass spectrometry is more analytically…”
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The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes by Kintzer, Alexander F., Thoren, Katie L., Sterling, Harry J., Dong, Ken C., Feld, Geoffrey K., Tang, Iok I., Zhang, Teri T., Williams, Evan R., Berger, James M., Krantz, Bryan A.

“…The assembly of bacterial toxins and virulence factors is critical to their function, but the regulation of assembly during infection has not been studied. We…”
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Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers by Tang, Iok I, Thoren, Katie L, Feld, Geoffrey K, Greenberg, Shoshana G, Krantz, Bryan A, Williams, Evan R, Sterling, Harry J, Kintzer, Alexander F

“…The anthrax lethal toxin protein transporter consists of protective antigen (PA) and lethal factor (LF), with LF unfolding for translocation into the host…”
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Charge Requirements for Proton Gradient-driven Translocation of Anthrax Toxin by Brown, Michael J., Thoren, Katie L., Krantz, Bryan A.

“…Anthrax lethal toxin is used as a model system to study protein translocation. The toxin is composed of a translocase channel, called protective antigen (PA),…”
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Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation by Thoren, Katie L, Worden, Evan J, Yassif, Jaime M, Krantz, Bryan A

“…Cellular compartmentalization requires machinery capable of translocating polypeptides across membranes. In many cases, transported proteins must first be…”
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Mass spectrometry methods for detecting monoclonal immunoglobulins in multiple myeloma minimal residual disease by Thoren, Katie L.

“…Mass spectrometry methods that can detect low levels of monoclonal immunoglobulin in serum have recently been developed. These assays are based on the…”
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Distinguishing Drug from Disease by Use of the Hydrashift 2/4 Daratumumab Assay by Thoren, Katie L, Pianko, Matthew J, Maakaroun, Youssef, Landgren, C Ola, Ramanathan, Lakshmi V

“…Daratumumab, a monoclonal antibody used to treat relapsed or refractory multiple myeloma, can interfere with protein electrophoresis and immunofixation assays…”
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MALDI-TOF mass spectrometry distinguishes daratumumab from M-proteins by Moore, Lauren M., Cho, Sun, Thoren, Katie L.

“…Daratumumab, a therapeutic IgG kappa monoclonal antibody, can cause a false positive interference on electrophoretic assays that are routinely used to monitor…”
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Tracking of low disease burden in multiple myeloma: Using mass spectrometry assays in peripheral blood by Chapman, Jessica R., Thoren, Katie L.

“…Efforts over the last 5 years have demonstrated that it is technically feasible to detect low levels of monoclonal proteins in peripheral blood using mass…”
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Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma by Moskowitz, Alison J., Schöder, Heiko, Gavane, Somali, Thoren, Katie L., Fleisher, Martin, Yahalom, Joachim, McCall, Susan J., Cadzin, Briana R., Fox, Stephanie Y., Gerecitano, John, Grewal, Ravinder, Hamlin, Paul A., Horwitz, Steven M., Kumar, Anita, Matasar, Matthew, Ni, Andy, Noy, Ariela, Palomba, M. Lia, Perales, Miguel-Angel, Portlock, Carol S., Sauter, Craig, Straus, David, Younes, Anas, Zelenetz, Andrew D., Moskowitz, Craig H.

“…Identification of prognostic factors for patients with relapsed/refractory Hodgkin lymphoma (HL) is essential for optimizing therapy with risk-adapted…”
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Identification of gamma heavy chain disease using MALDI-TOF mass spectrometry by Thoren, Katie L., Eveillard, Marion, Chan, Patrick, Doddi, Sital, Cho, Sun, Murata, Kazunori

“…We describe the use of MALDI-TOF mass spectrometry in the analysis of a suspected case of gamma heavy chain disease. The patient had an abnormal serum…”
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A novel method for the laboratory workup of anaphylactic transfusion reactions in haptoglobin‐deficient patients by Thoren, Katie L., Avecilla, Scott T., Klimek, Virginia, Goss, Cheryl

“…BACKGROUND Patients with congenital haptoglobin deficiency can develop anti‐haptoglobin antibodies after exposure to blood products, and they can suffer from…”
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Minimal Residual Disease in Myeloma: Application for Clinical Care and New Drug Registration by Anderson, Kenneth C, Auclair, Daniel, Adam, Stacey J, Agarwal, Amit, Anderson, Melissa, Avet-Loiseau, Hervé, Bustoros, Mark, Chapman, Jessica, Connors, Dana E, Dash, Ajeeta, Di Bacco, Alessandra, Du, Ling, Facon, Thierry, Flores-Montero, Juan, Gay, Francesca, Ghobrial, Irene M, Gormley, Nicole J, Gupta, Ira, Higley, Howard, Hillengass, Jens, Kanapuru, Bindu, Kazandjian, Dickran, Kelloff, Gary J, Kirsch, Ilan R, Kremer, Brandon, Landgren, Ola, Lightbody, Elizabeth, Lomas, Oliver C, Lonial, Sagar, Mateos, María-Victoria, Montes de Oca, Rocio, Mukundan, Lata, Munshi, Nikhil C, O'Donnell, Elizabeth K, Orfao, Alberto, Paiva, Bruno, Patel, Reshma, Pugh, Trevor J, Ramasamy, Karthik, Ray, Jill, Roshal, Mikhail, Ross, Jeremy A, Sigman, Caroline C, Thoren, Katie L, Trudel, Suzanne, Ulaner, Gary, Valente, Nancy, Weiss, Brendan M, Zamagni, Elena, Kumar, Shaji K

“…The development of novel agents has transformed the treatment paradigm for multiple myeloma, with minimal residual disease (MRD) negativity now achievable…”
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Suspect Screening Using LC-QqTOF Is a Useful Tool for Detecting Drugs in Biological Samples by Colby, Jennifer M, Thoren, Katie L, Lynch, Kara L

“…High-resolution mass spectrometers (HRMS), including quadrupole time of flight mass analyzers (QqTOF), are becoming more prevalent as screening tools in…”
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The unfolding story of anthrax toxin translocation by Thoren, Katie L., Krantz, Bryan A.

“…Summary The essential cellular functions of secretion and protein degradation require a molecular machine to unfold and translocate proteins either across a…”
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Substrate Binding Modulates the Reduction Potential of DNA Photolyase by Gindt, Yvonne M, Schelvis, Johannes P. M, Thoren, Katie L, Huang, Tina H

“…The reduction potential of the (FADH-/FADH•) couple in DNA photolyase was measured, and the value was found to be significantly higher than the values…”
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Voxelotor (GBT440) produces interference in measurements of hemoglobin S by Rutherford, Nicola J., Thoren, Katie L., Shajani-Yi, Zahra, Colby, Jennifer M.

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Comparison of Information-Dependent Acquisition on a Tandem Quadrupole TOF vs a Triple Quadrupole Linear Ion Trap Mass Spectrometer for Broad-Spectrum Drug Screening by Thoren, Katie L, Colby, Jennifer M, Shugarts, Sarah B, Wu, Alan H B, Lynch, Kara L

“…Liquid chromatography high-resolution mass spectrometry (LC-HRMS) with untargeted data collection is especially attractive for general unknown drug screening…”
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Use of a Daratumumab-Specific Immunofixation Assay to Assess Possible Immunotherapy Interference at a Major Cancer Center: Our Experience and Recommendations by Kirchhoff, Daniel C, Murata, Kazunori, Thoren, Katie L

“…BACKGROUNDThe incorporation of monoclonal antibodies, such as daratumumab, into multiple myeloma treatment regimens has led to the issue of false-positive…”
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Optimization and Validation of High-Resolution Mass Spectrometry Data Analysis Parameters by Colby, Jennifer M, Thoren, Katie L, Lynch, Kara L

“…High-resolution mass spectrometry (HRMS) has gained recognition as a valuable tool for comprehensive drug screening in a variety of biological matrices. HRMS…”
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