Search Results - "Thoreau, Etienne"

Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne by Fournier, Jean-François, Clary, Laurence, Chambon, Sandrine, Dumais, Laurence, Harris, Craig Steven, Millois, Corinne, Pierre, Romain, Talano, Sandrine, Thoreau, Étienne, Aubert, Jérome, Aurelly, Michèle, Bouix-Peter, Claire, Brethon, Anne, Chantalat, Laurent, Christin, Olivier, Comino, Catherine, El-Bazbouz, Ghizlane, Ghilini, Anne-Laurence, Isabet, Tatiana, Lardy, Claude, Luzy, Anne-Pascale, Mathieu, Céline, Mebrouk, Kenny, Orfila, Danielle, Pascau, Jonathan, Reverse, Kevin, Roche, Didier, Rodeschini, Vincent, Hennequin, Laurent François

“…The use of an interleukin β antibody is currently being investigated in the clinic for the treatment of acne, a dermatological disorder affecting 650M persons…”
Get full text

Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma by Fournier, Jean-François, Bhurruth-Alcor, Yushma, Musicki, Branislav, Aubert, Jérome, Aurelly, Michèle, Bouix-Peter, Claire, Bouquet, Karinne, Chantalat, Laurent, Delorme, Marion, Drean, Bénédicte, Duvert, Gwenaelle, Fleury-Bregeot, Nicolas, Gauthier, Blanche, Grisendi, Karine, Harris, Craig S., Hennequin, Laurent F., Isabet, Tatiana, Joly, Florence, Lafitte, Guillaume, Millois, Corinne, Morgentin, Rémy, Pascau, Jonathan, Piwnica, David, Rival, Yves, Soulet, Catherine, Thoreau, Étienne, Tomas, Loïc

“…[Display omitted] •A novel squaramide-based scaffold for HDAC inhibition is proposed.•Inhibitors are optimized for topical route of administration.•Aqueous and…”
Get full text

Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne by Thoreau, Etienne, Arlabosse, Jean-Marie, Bouix-Peter, Claire, Chambon, Sandrine, Chantalat, Laurent, Daver, Sébastien, Dumais, Laurence, Duvert, Gwenaëlle, Feret, Angélique, Ouvry, Gilles, Pascau, Jonathan, Raffin, Catherine, Rodeville, Nicolas, Soulet, Catherine, Tabet, Samuel, Talano, Sandrine, Portal, Thibaud

“…[Display omitted] •X-ray of known RARγ-agonist CD437- RARγ complex was obtained.•Hypothesis for the isotype selectivity of known RARγ-agonist CD437 are…”
Get full text

Discovery of phenoxyindazoles and phenylthioindazoles as RORγ inverse agonists by Ouvry, Gilles, Bouix-Peter, Claire, Ciesielski, Fabrice, Chantalat, Laurent, Christin, Olivier, Comino, Catherine, Duvert, Denis, Feret, Christophe, Harris, Craig S., Lamy, Laurent, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Pascau, Jonathan, Parnet, Véronique, Perrin, Agnès, Pierre, Romain, Polge, Gaëlle, Raffin, Catherine, Rival, Yves, Taquet, Nathalie, Thoreau, Etienne, Hennequin, Laurent F.

“…[Display omitted] Targeting the IL17 pathway and more specifically the nuclear receptor RORγ is thought to be beneficial in multiple skin disorders. The Letter…”
Get full text

New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space by Brethon, Anne, Chantalat, Laurent, Christin, Olivier, Clary, Laurence, Fournier, Jean-François, Gastreich, Marcus, Harris, Craig S., Isabet, Tatiana, Pascau, Jonathan, Thoreau, Etienne, Roche, Didier, Rodeschini, Vincent

“…[Display omitted] Virtual fragmentation of a library of 12,000 compounds inspired by natural products led to a dataset of 153,000 fragments that was used as a…”
Get full text

Sulfoximines as potent RORγ inverse agonists by Ouvry, Gilles, Bihl, Franck, Bouix-Peter, Claire, Christin, Olivier, Defoin-Platel, Claire, Deret, Sophie, Feret, Christophe, Froude, David, Hacini-Rachinel, Feriel, Harris, Craig S., Hervouet, Catherine, Lafitte, Guillaume, Luzy, Anne-Pascale, Musicki, Branislav, Orfila, Danielle, Parnet, Veronique, Pascau, Coralie, Pascau, Jonathan, Pierre, Romain, Raffin, Catherine, Rossio, Patricia, Spiesse, Delphine, Taquet, Nathalie, Thoreau, Etienne, Vatinel, Rodolphe, Vial, Emmanuel, Hennequin, Laurent F.

“…Compound 4a CD4 IL-17 IC50 = 17 nM. [Display omitted] Progress in the identification of suitable RORγ inverse agonists as clinical candidates has been hampered…”
Get full text

Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors by Ouvry, Gilles, Clary, Laurence, Tomas, Loïc, Aurelly, Michèle, Bonnary, Laetitia, Borde, Emilie, Bouix-Peter, Claire, Chantalat, Laurent, Defoin-Platel, Claire, Deret, Sophie, Forissier, Mathieu, Harris, Craig S, Isabet, Tatiana, Lamy, Laurent, Luzy, Anne-Pascale, Pascau, Jonathan, Soulet, Catherine, Taddei, Alessandro, Taquet, Nathalie, Thoreau, Etienne, Varvier, Emeric, Vial, Emmanuel, Hennequin, Laurent F

“…Minor structural modificationssometimes single atom changescan have a dramatic impact on the properties of compounds. This is illustrated here on structures…”
Get full text

Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis by Ouvry, Gilles, Atrux‐Tallau, Nicolas, Bihl, Franck, Bondu, Aline, Bouix‐Peter, Claire, Carlavan, Isabelle, Christin, Olivier, Cuadrado, Marie‐Josée, Defoin‐Platel, Claire, Deret, Sophie, Duvert, Denis, Feret, Christophe, Forissier, Mathieu, Fournier, Jean‐François, Froude, David, Hacini‐Rachinel, Fériel, Harris, Craig Steven, Hervouet, Catherine, Huguet, Hélène, Lafitte, Guillaume, Luzy, Anne‐Pascale, Musicki, Branislav, Orfila, Danielle, Ozello, Benjamin, Pascau, Coralie, Pascau, Jonathan, Parnet, Véronique, Peluchon, Guillaume, Pierre, Romain, Piwnica, David, Raffin, Catherine, Rossio, Patricia, Spiesse, Delphine, Taquet, Nathalie, Thoreau, Etienne, Vatinel, Rodolphe, Vial, Emmanuel, Hennequin, Laurent François

“…With possible implications in multiple autoimmune diseases, the retinoic acid receptor‐related orphan receptor RORγ has become a sought‐after target in the…”
Get full text

A genetic algorithm for the automated generation of small organic molecules: drug design using an evolutionary algorithm by Douguet, D, Thoreau, E, Grassy, G

“…Rational drug design involves finding solutions to large combinatorial problems for which an exhaustive search is impractical. Genetic algorithms provide a…”
Get full text

Rhenium Carbonyl Complexes of .beta.-Estradiol Derivatives with High Affinity for the Estradiol Receptor: An Approach to Selective Organometallic Radiopharmaceuticals by Top, Siden, El Hafa, Hassane, Vessieres, Anne, Quivy, Jacques, Vaissermann, Jacqueline, Hughes, Donald W, McGlinchey, Michael J, Mornon, Jean-Paul, Thoreau, Etienne, Jaouen, Gerard

Get full text

A Genetic Algorithm for the Automated Generation of Small Organic Molecules by Douguet, Dominique, Thoreau, Etienne, Grassy, Gérard

Get full text

Quantitative structure-activity relationship studies of RAR α, β, γ retinoid agonists by Douguet, Dominique, Thoreau, Etienne, Grassy, Gérard

“…Structure‐Activity Relationships have been established for 140 synthetic retinoid agonists. Retinoids, natural and synthetic analogues of vitamin A, are…”
Get full text