Search Results - "Thomson, Daniel W."
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lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs
Published in Nucleic acids research (28-01-2015)“…Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been examined for biological function…”
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On measuring miRNAs after transient transfection of mimics or antisense inhibitors
Published in PloS one (24-01-2013)“…The ability to alter microRNA (miRNA) abundance is crucial for studying miRNA function. To achieve this there is widespread use of both exogenous…”
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Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion
Published in The EMBO journal (17-09-2014)“…The microRNAs of the miR‐200 family maintain the central characteristics of epithelia and inhibit tumor cell motility and invasiveness. Using the Ago‐HITS‐CLIP…”
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Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin
Published in Nucleic acids research (01-01-2015)“…High-throughput sequencing reveals an abundance of microRNA-sized fragments derived from larger non-coding RNAs. Roles for these small RNAs in gene silencing…”
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Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage
Published in Nucleic acids research (01-07-2011)“…The Ago2 component of the RNA-induced silencing complex (RISC) is an endonuclease that cleaves mRNAs that base pair with high complementarity to RISC-bound…”
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Experimental strategies for microRNA target identification
Published in Nucleic acids research (01-09-2011)“…MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression in most biological processes. They act by guiding the RNAi-induced silencing complex…”
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Endogenous microRNA sponges: evidence and controversy
Published in Nature reviews. Genetics (01-05-2016)“…Key Points The competitive endogenous RNA (ceRNA) hypothesis posits that transcripts with shared microRNA binding sites compete for post-transcriptional…”
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Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia
Published in Leukemia (01-08-2020)“…Blast crisis of chronic myeloid leukemia is associated with poor survival and the accumulation of genomic lesions. Using whole-exome and/or RNA sequencing of…”
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Experimental strategies for microRNA target identification
Published in Nucleic acids research (01-09-2011)Get full text
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