Isothiazolinones are still widely used in paints purchased in five European countries: a follow‐up study

Summary Background An increasing incidence of contact allergy to methylisothiazolinone (MI) has been seen, caused, in particular, by cosmetic products and paints. A study from 2015 showed that 93.0% of paints bought in five European countries contained MI. New regulations have been discussed for pai...

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Bibliographic Details
Published in:	Contact dermatitis Vol. 78; no. 4; pp. 246 - 253
Main Authors:	Thomsen, Andreas V., Schwensen, Jakob F., Bossi, Rossana, Banerjee, Piu, Giménez‐Arnau, Elena, Lepoittevin, Jean‐Pierre, Lidén, Carola, Uter, Wolfgang, White, Ian R., Johansen, Jeanne D.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-04-2018 Wiley Subscription Services, Inc Wiley
Subjects:	Allergies benzisothiazolinone Chemical Sciences Chromatography Chromatography, High Pressure Liquid - methods Denmark Dermatitis, Allergic Contact - etiology Dermatitis, Allergic Contact - prevention & control dichlorooctylisothiazolinone environmental label exposure analysis France Germany Humans Incidence Liquid chromatography Mass spectroscopy Materials Testing Medicin och hälsovetenskap methylchloroisothiazolinone methylisothiazolinone Occupational Exposure - adverse effects octylisothiazolinone Organic chemistry paint Paint - adverse effects Paint - analysis Paints Risk Assessment safety data sheet Statistical analysis Statistics, Nonparametric Thiazoles - analysis Thiazoles - chemistry United Kingdom environmental label dichlorooctylisothiazolinone octylisothiazolinone safety data sheet methylisothiazolinone methylchloroisothiazolinone paint benzisothiazolinone exposure analysis
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Summary:	Summary Background An increasing incidence of contact allergy to methylisothiazolinone (MI) has been seen, caused, in particular, by cosmetic products and paints. A study from 2015 showed that 93.0% of paints bought in five European countries contained MI. New regulations have been discussed for paints in the EU, which may have influenced this market. Objectives To re‐evaluate the use and concentrations of MI and four other isothiazolinones in water‐based wall paints. Methods Water‐based white wall paints (n = 60) were purchased in retail stores in five European countries: Denmark, France, Germany, Sweden, and the United Kingdom. The paints were analysed for isothiazolione content by the use of high‐performance liquid chromatography coupled to ultraviolet detection, and the results were confirmed with high‐performance liquid chromatography–tandem mass spectrometry. Results MI was identified in 55 (91.7%) of the paints, with concentrations ranging from 1.1 to 142.7 ppm. The other isothiazolinones were identified in 20.0% [methylchloroisothiazolinone (MCI)] to 88.3% [benzisothiazolinone (BIT)] of the paints. BIT concentrations varied significantly between countries, whereas MI and MCI concentrations did not. There were no statistically significant differences in MI, MCI and BIT concentrations between the current study and the 2015 study. Conclusions MI and other isothiazolinones are widely used in paints available in Europe. Their use does not seem to be decreasing.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0105-1873 1600-0536 1600-0536
DOI:	10.1111/cod.12937