Search Results - "Thompson, Wendy L."

Generation of multi-cellular human liver organoids from pluripotent stem cells by Thompson, Wendy L, Takebe, Takanori

“…A growing number of in vitro hepatic models exist to study human genetics, liver biology, disease modeling and drug development and range from 2D hepatocytes…”
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Human liver model systems in a dish by Thompson, Wendy L., Takebe, Takanori

“…The human adult liver has a multi‐cellular structure consisting of large lobes subdivided into lobules containing portal triads and hepatic cords lined by…”
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The promise of human organoids in the digestive system by Funata, Masaaki, Nio, Yasunori, Erion, Derek M., Thompson, Wendy L., Takebe, Takanori

“…The advent of organoid technology has enabled scientists and clinicians to utilize cells from primary tissues or pluripotent stem cells (PSCs) to grow…”
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MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult by Thompson, Wendy L, Karpus, William J, Van Eldik, Linda J

“…An endotoxin insult mimics a severe peripheral infection and recent evidence suggests that a single exposure can cause long-term cognitive deficits. A…”
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High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived Organoids by Shinozawa, Tadahiro, Kimura, Masaki, Cai, Yuqi, Saiki, Norikazu, Yoneyama, Yosuke, Ouchi, Rie, Koike, Hiroyuki, Maezawa, Mari, Zhang, Ran-Ran, Dunn, Andrew, Ferguson, Autumn, Togo, Shodai, Lewis, Kyle, Thompson, Wendy L., Asai, Akihiro, Takebe, Takanori

“…Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a…”
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Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary by Koike, Hiroyuki, Iwasawa, Kentaro, Ouchi, Rie, Maezawa, Mari, Giesbrecht, Kirsten, Saiki, Norikazu, Ferguson, Autumn, Kimura, Masaki, Thompson, Wendy L., Wells, James M., Zorn, Aaron M., Takebe, Takanori

“…Organogenesis is a complex and interconnected process that is orchestrated by multiple boundary tissue interactions 1 – 7 . However, it remains unclear how…”
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Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells by Koike, Hiroyuki, Iwasawa, Kentaro, Ouchi, Rie, Maezawa, Mari, Kimura, Masaki, Kodaka, Asuka, Nishii, Shozo, Thompson, Wendy L., Takebe, Takanori

“…Human organoids are emerging as a valuable resource to investigate human organ development and disease. The applicability of human organoids has been limited,…”
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Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes by Thompson, Wendy L, Van Eldik, Linda J

“…Abstract The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative and acute diseases associated with infiltration of…”
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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH by Kimura, Masaki, Iguchi, Takuma, Iwasawa, Kentaro, Dunn, Andrew, Thompson, Wendy L., Yoneyama, Yosuke, Chaturvedi, Praneet, Zorn, Aaron M., Wintzinger, Michelle, Quattrocelli, Mattia, Watanabe-Chailland, Miki, Zhu, Gaohui, Fujimoto, Masanobu, Kumbaji, Meenasri, Kodaka, Asuka, Gindin, Yevgeniy, Chung, Chuhan, Myers, Robert P., Subramanian, G. Mani, Hwa, Vivian, Takebe, Takanori

“…Genotype-phenotype associations for common diseases are often compounded by pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of…”
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Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches by Van Eldik, Linda J, Thompson, Wendy L, Ralay Ranaivo, Hantamalala, Behanna, Heather A, Martin Watterson, D

“…Inflammation is the body's defense mechanism against threats such as bacterial infection, undesirable substances, injury, or illness. The process is complex…”
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Association of injury mechanism with the risk of cervical spine fractures by Thompson, Wendy L, Stiell, Ian G, Clement, Catherine M, Brison, Robert J

“…A full understanding of an injury event and the mechanical forces involved should be important for predicting specific anatomical patterns of injury. Yet,…”
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Corrigendum to “Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes” [Brain Res. 1287 (2009) 47–57] by Thompson, Wendy L, Van Eldik, Linda J

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P3-374: The role of the chemokine MCP-1 in brain inflammation during endotoxemia by Thompson, Wendy L, Van Eldik, Linda J

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Inflammatory cytokines stimulate the chemokines GGL2/MCP-1 and GGL7/MGP-7 through NFkB and MAPK dependent pathways in rat astrocytes by THOMPSON, Wendy L, VAN ELDIK, Linda J

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Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected] by Thompson, Wendy L, Van Eldik, Linda J

“…The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative and acute diseases associated with infiltration of peripheral…”
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Taking care of culturally different and non-English speaking patients by Thompson, W L, Thompson, 2nd, T L, House, R M

“…Many physicians evaluate and care for non-English speaking patients and patients from different cultures. If not carefully considered, cultural factors,…”
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Interaction of gender, developmental stage, and temperament on adolescent coping responses to social stress by Thompson, Wendy L

“…The purpose of this study was to investigate how gender, developmental stage, and temperament interact with adolescents' coping responses to social stress. The…”
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The relationship between mechanism of injury and cervical spine fractures by Thompson, Wendy L

“…Background. Understanding the injury event and the applied forces released during the event are important in predicting specific patterns of injury. Yet,…”
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Sexual problems in chronic respiratory disease. Achieving and maintaining intimacy by Thompson, W L

“…Chronic obstructive pulmonary disease (COPD) may be linked to several types of sexual dysfunction, but presence of the disease does not preclude enjoyment of…”
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Specific psychotherapy approaches to medical-surgical patients by Snyderman, D A, Thompson, W L

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