Search Results - "Thompson, Ruth"

The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design by Thompson, Ruth, Eastman, Alan

“…Many anticancer agents damage DNA and activate cell cycle checkpoints that permit time for the cells to repair their DNA and recover. These checkpoints have…”
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Modification of Seurat v4 for the Development of a Phase Assignment Tool Able to Distinguish between G2 and Mitotic Cells by Watson, Steven, Porter, Harry, Sudbery, Ian, Thompson, Ruth

“…Single-cell RNA sequencing (scRNAseq) is a rapidly advancing field enabling the characterisation of heterogeneous gene expression profiles within a population…”
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Navigating ethical challenges in online wildlife trade research by Morcatty, Thais Q., Su, Shan, Siriwat, Penthai, Andersson, Astrid Alex, Atoussi, Sadek, Feddema, Kim, Henriques, Sergio, Janssen, Jordi, Karve, Anushri, Pytka, Jennifer, Thompson, Ruth M., Nijman, Vincent, Wright, Joss, Roberts, David L.

“…The surge in internet accessibility has transformed wildlife trade by facilitating the acquisition of wildlife through online platforms. This scenario presents…”
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Single-Molecule Reconstruction of Oligonucleotide Secondary Structure by Atomic Force Microscopy by Pyne, Alice, Thompson, Ruth, Leung, Carl, Roy, Debdulal, Hoogenboom, Bart W.

“…Based on soft‐touch atomic force microscopy, a method is described to reconstruct the secondary structure of single extended biomolecules, without the need for…”
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Ethics and governance for internet‐based conservation science research by Thompson, Ruth M., Hall, Jordan, Morrison, Chris, Palmer, Nicole R., Roberts, David L.

“…Internet‐based research is increasingly important for conservation science and has wide‐ranging applications and contexts, including culturomics, illegal…”
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Human Melioidosis Caused by Novel Transmission of Burkholderia pseudomallei from Freshwater Home Aquarium, United States by Dawson, Patrick, Duwell, Monique M, Elrod, Mindy G, Thompson, Ruth J, Crum, David A, Jacobs, Ruth M, Gee, Jay E, Kolton, Cari B, Liu, Lindy, Blaney, David D, Thomas, LaToya Griffin, Sockwell, Denise, Weiner, Zachary, Bower, William A, Hoffmaster, Alex R, Salzer, Johanna S

“…Nearly all cases of melioidosis in the continental United States are related to international travel to areas to which Burkholderia pseudomallei, the bacterium…”
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Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy by Harrision, Daniel, Gravells, Polly, Thompson, Ruth, Bryant, Helen E.

“…Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor…”
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The Mre11 nuclease is critical for the sensitivity of cells to Chk1 inhibition by Thompson, Ruth, Montano, Ryan, Eastman, Alan

“…The Chk1 kinase is required for the arrest of cell cycle progression when DNA is damaged, and for stabilizing stalled replication forks. As a consequence, many…”
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Sensitization of human cancer cells to gemcitabine by the Chk1 inhibitor MK-8776: cell cycle perturbation and impact of administration schedule in vitro and in vivo by Montano, Ryan, Thompson, Ruth, Chung, Injae, Hou, Huagang, Khan, Nadeem, Eastman, Alan

“…Chk1 inhibitors have emerged as promising anticancer therapeutic agents particularly when combined with antimetabolites such as gemcitabine, cytarabine or…”
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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus by Ando, Kiyohiro, Parsons, Melissa J, Shah, Richa B, Charendoff, Chloé I, Paris, Sheré L, Liu, Peter H, Fassio, Sara R, Rohrman, Brittany A, Thompson, Ruth, Oberst, Andrew, Sidi, Samuel, Bouchier-Hayes, Lisa

“…The PIDDosome (PIDD-RAIDD-caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet…”
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CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway by Green, Luke R, Issa, Rahaf, Albaldi, Fawzyah, Urwin, Lucy, Thompson, Ruth, Khalid, Henna, Turner, Claire E, Ciani, Barbara, Partridge, Lynda J, Monk, Peter N

“…Epithelial colonization is a critical first step in bacterial pathogenesis. can utilize several host factors to associate with cells, including α5β1 integrin…”
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How Cells Handle DNA Breaks during Mitosis: Detection, Signaling, Repair, and Fate Choice by Thompson, Ruth, Gatenby, Rachel, Sidi, Samuel

“…Mitosis is controlled by a complex series of signaling pathways but mitotic control following DNA damage remains poorly understood. Effective DNA damage…”
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Human Melioidosis Caused by Novel Transmission of Burkholderia pseudomallei from Freshwater Home Aquarium, United States1 by Dawson, Patrick, Duwell, Monique M., Elrod, Mindy G., Thompson, Ruth J., Crum, David A., Jacobs, Ruth M., Gee, Jay E., Kolton, Cari B., Liu, Lindy, Blaney, David D., Thomas, LaToya Griffin, Sockwell, Denise, Weiner, Zachary, Bower, William A., Hoffmaster, Alex R., Salzer, Johanna S.

“…Nearly all cases of melioidosis in the continental United States are related to international travel to areas to which Burkholderia pseudomallei , the…”
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Suppression of Apoptosis by PIF1 Helicase in Human Tumor Cells by GAGOU, Mary E, GANESH, Anil, THOMPSON, Ruth, PHEAR, Geraldine, SANDERS, Cyril, MEUTH, Mark

“…Defining the processes that sustain telomere maintenance is critical to our understanding of cancer and longevity. PIF1 is a nonprocessive 5'->3' human DNA…”
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Transmission of vaccinia virus, possibly through sexual contact, to a woman at high risk for adverse complications by Said, Maria A, Haile, Charles, Palabindala, Venkataraman, Barker, Naomi, Myers, Robert, Thompson, Ruth, Wilson, Lucy, Allan-Martinez, Frances, Montgomery, Jay, Monroe, Benjamin, Tack, Danielle, Reynolds, Mary, Damon, Inger, Blythe, David

“…Severe adverse events, including eczema vaccinatum (EV), can result after smallpox vaccination. Persons at risk for EV include those with underlying…”
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Aortic thrombosis in a dog with chronic lymphocytic leukemia by Ripplinger, Angel, Silva, Ana Paula da, Wrzesinski, Mathias Reginatto, Ferrarin, Dênis Antonio, Schwab, Marcelo Luís, Pozzobon, Ricardo, Flores, Mariana Martins, Thompson, Ruth Pamela, Mario, Fabiana, Mazzanti, Alexandre

“…The aim of this report was to describe a case of aortic thrombosis (AT) secondary to chronic lymphocytic leukemia (CLL). Although, different types of neoplasms…”
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Clinical-epidemiological, anatomic-pathological, histochemical and immunohistochemical characterization of renal cystadenocarcinoma-nodular dermatofibrosis syndrome in 11 German Shepherd dogs by Thompson, Ruth Pamela M., Lamego, Eryca C., Melo, Stella Maris P., Irigoyen, Luiz Francisco, Fighera, Rafael A., Kommers, Glaucia Denise

“…Eleven cases of renal cystadenoma/cystadenocarcinoma-nodular dermatofibrosis syndrome (RCND) are described in German Shepherd dogs diagnosed from January 1994…”
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Availability and use of web-based interventions for patients with head and neck cancer: a scoping review by Kelly, Rosemary, Gordon, Peter, Thompson, Ruth, Semple, Cherith

“…Purpose To identify and review the nature, scope and use of web-based interventions for patients with head and neck cancer (HNC). Method A scoping review…”
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A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase by Sakurikar, Nandini, Thompson, Ruth, Montano, Ryan, Eastman, Alan

“…DNA damage activates Checkpoint kinase 1 (Chk1) to halt cell cycle progression thereby preventing further DNA replication and mitosis until the damage has been…”
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Treatment with the Chk1 inhibitor G�6976 enhances cisplatin cytotoxicity in SCLC cells by Thompson, Ruth

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